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Table 2—

Mean pharmacokinetic summary measures after inhalation of 6 mg INH or subcutaneous injection of 18 U RHI on two different study days in 17 healthy volunteers (baseline values subtracted)

Serum insulin measuresINHRHIRatio/difference*90% CI*P values
Maximal serum insulin concentration (Cmax) (μU/ml) 66.9 61.0 110% (INH/RHI) 86–139 NS 
Time to maximal concentration (tmax) (min)* 55 148 −93 (INH−RHI) −132 to −54 < 0.001 
AUC-Insulin0–60 (μU · ml–1 · min−1) 2,740 1,650 166% (INH/RHI) 120–229 < 0.05 
AUC-Insulin0–180 (μU · ml–1 · min–1) 8,390 7,560 111% (INH/RHI) 90–137 NS 
AUC-Insulin0–600 (μU · ml–1 · min–1) 14,000 17,700 79% (INH/RHI) 67–92 < 0.05 
Serum insulin measuresINHRHIRatio/difference*90% CI*P values
Maximal serum insulin concentration (Cmax) (μU/ml) 66.9 61.0 110% (INH/RHI) 86–139 NS 
Time to maximal concentration (tmax) (min)* 55 148 −93 (INH−RHI) −132 to −54 < 0.001 
AUC-Insulin0–60 (μU · ml–1 · min−1) 2,740 1,650 166% (INH/RHI) 120–229 < 0.05 
AUC-Insulin0–180 (μU · ml–1 · min–1) 8,390 7,560 111% (INH/RHI) 90–137 NS 
AUC-Insulin0–600 (μU · ml–1 · min–1) 14,000 17,700 79% (INH/RHI) 67–92 < 0.05 
*

Arithmetic mean;

one-sided for tmax and AUC-Insulin0–60, two-sided for all other measures;

geometric mean.

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