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Table 3—

Incidence (percentage of patients reporting one or more hypoglycemic episode) and percentage risk reduction of symptomatic, nocturnal, and nonnocturnal hypoglycemia and severe, severe nocturnal, and severe nonnocturnal hypoglycemia in patients receiving insulin glargine versus NPH insulin

Type of symptomatic hypoglycemiaInsulin glargine (% of patients)NPH insulin (% of patients)PInsulin glargine significant % risk reduction
Overall documented 54.2 61.2 0.0006 11 
    Plasma glucose ≤72 mg/dl (≤4.0 mmol/l) 46.0 53.3 0.0004 14 
    Plasma glucose ≤56 mg/dl (≤3.1 mmol/l) 29.9 37.0 0.0002 19 
Nocturnal documented 28.4 38.2 <0.0001 26 
    Plasma glucose ≤72 mg/dl (≤4.0 mmol/l) 23.9 33.9 <0.0001 29 
    Plasma glucose ≤56 mg/dl (≤3.1 mmol/l) 16.3 23.1 <0.0001 29 
Nonnocturnal documented 49.6 51.7 0.4642 — 
    Plasma glucose ≤72 mg/dl (≤4.0 mmol/l) 40.1 42.9 0.2553 — 
    Plasma glucose ≤56 mg/dl (≤3.1 mmol/l) 22.8 25.4 0.1545 — 
Severe documented 1.4 2.6 0.0442 46 
    Plasma glucose ≤72 mg/dl (≤4.0 mmol/l) 1.1 2.0 0.1089 — 
    Plasma glucose ≤56 mg/dl (≤3.1 mmol/l) 0.9 1.5 0.1735 — 
Severe nocturnal documented 0.7 1.7 0.0231 59 
    Plasma glucose ≤72 mg/dl (≤4.0 mmol/l) 0.6 1.5 0.0416 60 
    Plasma glucose ≤56 mg/dl (≤3.1 mmol/l) 0.5 1.3 0.0461 62 
Severe nonnocturnal documented 0.8 0.9 0.7296 — 
    Plasma glucose ≤72 mg/dl (≤4.0 mmol/l) 0.6 0.6 0.9042 — 
    Plasma glucose ≤56 mg/dl (≤3.1 mmol/l) 0.4 0.3 0.4669 — 
Type of symptomatic hypoglycemiaInsulin glargine (% of patients)NPH insulin (% of patients)PInsulin glargine significant % risk reduction
Overall documented 54.2 61.2 0.0006 11 
    Plasma glucose ≤72 mg/dl (≤4.0 mmol/l) 46.0 53.3 0.0004 14 
    Plasma glucose ≤56 mg/dl (≤3.1 mmol/l) 29.9 37.0 0.0002 19 
Nocturnal documented 28.4 38.2 <0.0001 26 
    Plasma glucose ≤72 mg/dl (≤4.0 mmol/l) 23.9 33.9 <0.0001 29 
    Plasma glucose ≤56 mg/dl (≤3.1 mmol/l) 16.3 23.1 <0.0001 29 
Nonnocturnal documented 49.6 51.7 0.4642 — 
    Plasma glucose ≤72 mg/dl (≤4.0 mmol/l) 40.1 42.9 0.2553 — 
    Plasma glucose ≤56 mg/dl (≤3.1 mmol/l) 22.8 25.4 0.1545 — 
Severe documented 1.4 2.6 0.0442 46 
    Plasma glucose ≤72 mg/dl (≤4.0 mmol/l) 1.1 2.0 0.1089 — 
    Plasma glucose ≤56 mg/dl (≤3.1 mmol/l) 0.9 1.5 0.1735 — 
Severe nocturnal documented 0.7 1.7 0.0231 59 
    Plasma glucose ≤72 mg/dl (≤4.0 mmol/l) 0.6 1.5 0.0416 60 
    Plasma glucose ≤56 mg/dl (≤3.1 mmol/l) 0.5 1.3 0.0461 62 
Severe nonnocturnal documented 0.8 0.9 0.7296 — 
    Plasma glucose ≤72 mg/dl (≤4.0 mmol/l) 0.6 0.6 0.9042 — 
    Plasma glucose ≤56 mg/dl (≤3.1 mmol/l) 0.4 0.3 0.4669 — 
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