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Table 4—

Odds ratios for diabetic retinopathy status of siblings of randomly chosen probands

Reference groupOdds ratio95% CI
Four retinopathy classes    
    HbA1c ≥10.1% <10.1% 2.16 1.40–3.05 
    Diabetes duration ≥11 years <11 years 5.47 3.50–8.55 
    PDR No diabetic retinopathy 1.14 0.64–2.03 
    NPDR-S No diabetic retinopathy 0.95 0.53–1.70 
    NPDR-E No diabetic retinopathy 0.57 0.35–0.93 
Three retinopathy classes    
    HbA1c ≥10.1% <10.1% 2.39 1.60–3.58 
    Diabetes duration ≥11 years <11 years 5.98 3.76–9.51 
    PDR or NPDR-S No diabetic retinopathy 1.06 0.63–1.79 
    NPDR-E No diabetic retinopathy 0.56 0.33–0.94 
Two retinopathy classes    
    HbA1c ≥10.1% <10.1% 2.11 1.31–3.40 
    Diabetes duration ≥11 years <11 years 5.46 3.30–9.04 
    PDR or NPDR-S NPDR-E or no diabetic retinopathy 1.71 1.03–2.84 
Reference groupOdds ratio95% CI
Four retinopathy classes    
    HbA1c ≥10.1% <10.1% 2.16 1.40–3.05 
    Diabetes duration ≥11 years <11 years 5.47 3.50–8.55 
    PDR No diabetic retinopathy 1.14 0.64–2.03 
    NPDR-S No diabetic retinopathy 0.95 0.53–1.70 
    NPDR-E No diabetic retinopathy 0.57 0.35–0.93 
Three retinopathy classes    
    HbA1c ≥10.1% <10.1% 2.39 1.60–3.58 
    Diabetes duration ≥11 years <11 years 5.98 3.76–9.51 
    PDR or NPDR-S No diabetic retinopathy 1.06 0.63–1.79 
    NPDR-E No diabetic retinopathy 0.56 0.33–0.94 
Two retinopathy classes    
    HbA1c ≥10.1% <10.1% 2.11 1.31–3.40 
    Diabetes duration ≥11 years <11 years 5.46 3.30–9.04 
    PDR or NPDR-S NPDR-E or no diabetic retinopathy 1.71 1.03–2.84 

Data are from logistic regression models accounting for familial correlations, proportional odds model with cumulative logits.

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