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Table 4—

Prevalence of diabetic nephropathy categorized according to total and differential white cell count quartiles and multivariate analysis of the impact of leukocyte count on diabetic nephropathy

1st quartile2nd quartile3rd quartile4th quartileP for trend
Total WBC count 2.55–5.59 5.60–6.66 6.67–7.83 7.84–11.94 <0.001 
    Normoalbuminuria (%) 72.3 60.7 58.2 49.5 <0.0001 
    Microalbuminuria (%) 17.7 22.8 23.2 23.7 <0.0001 
    Overt nephropathy (%) 10.1 16.5 18.6 26.9 0.001 
    Multivariate 1.0 2.0 (1.33–3.10) 2.4 (1.59–3.70) 4.2 (2.77–6.40) — 
Neutrophil count 1,005–2,979 2,980–3,741 3,742–4,772 4,773–10,341 <0.001 
    Normoalbuminuria (%) 72.7 64.9 59.2 43.8 <0.0001 
    Microalbuminuria (%) 18.7 22.4 22.4 23.8 <0.0001 
    Overt nephropathy (%) 8.7 12.7 18.4 32.4 0.019 
    Multivariate 1.0 1.6 (1.00–2.41) 2.5 (1.65–3.87) 5.5 (3.64–8.40) — 
Monocyte count 47.9–341 342–433 434–559 560–1685 <0.001 
    Normoalbuminuria (%) 67.8 68.2 60.3 44.3 <0.0001 
    Microalbuminuria (%) 20.1 19.1 22.2 26.0 0.019 
    Overt nephropathy (%) 12.2 12.7 17.6 29.7 0.995 
    Multivariate 1.0 1.1 (0.69–1.62) 1.7 (1.13–2.56) 3.5 (2.36–5.30) — 
Lymphocyte count 221–1,622 1,623–2,067 2,068–2,580 2,581–5,958 <0.001 
     Normoalbuminuria (%) 54.3 60.0 63.8 62.4 0.0001 
     Microalbuminuria (%) 17.8 23.0 22.2 24.3 <0.0001 
     Overt nephropathy (%) 27.8 17.0 14.1 13.2 0.006 
    Multivariate 1.0 0.7 (0.46–0.99) 0.6 (0.38–0.83) 0.6 (0.43–0.95) — 
1st quartile2nd quartile3rd quartile4th quartileP for trend
Total WBC count 2.55–5.59 5.60–6.66 6.67–7.83 7.84–11.94 <0.001 
    Normoalbuminuria (%) 72.3 60.7 58.2 49.5 <0.0001 
    Microalbuminuria (%) 17.7 22.8 23.2 23.7 <0.0001 
    Overt nephropathy (%) 10.1 16.5 18.6 26.9 0.001 
    Multivariate 1.0 2.0 (1.33–3.10) 2.4 (1.59–3.70) 4.2 (2.77–6.40) — 
Neutrophil count 1,005–2,979 2,980–3,741 3,742–4,772 4,773–10,341 <0.001 
    Normoalbuminuria (%) 72.7 64.9 59.2 43.8 <0.0001 
    Microalbuminuria (%) 18.7 22.4 22.4 23.8 <0.0001 
    Overt nephropathy (%) 8.7 12.7 18.4 32.4 0.019 
    Multivariate 1.0 1.6 (1.00–2.41) 2.5 (1.65–3.87) 5.5 (3.64–8.40) — 
Monocyte count 47.9–341 342–433 434–559 560–1685 <0.001 
    Normoalbuminuria (%) 67.8 68.2 60.3 44.3 <0.0001 
    Microalbuminuria (%) 20.1 19.1 22.2 26.0 0.019 
    Overt nephropathy (%) 12.2 12.7 17.6 29.7 0.995 
    Multivariate 1.0 1.1 (0.69–1.62) 1.7 (1.13–2.56) 3.5 (2.36–5.30) — 
Lymphocyte count 221–1,622 1,623–2,067 2,068–2,580 2,581–5,958 <0.001 
     Normoalbuminuria (%) 54.3 60.0 63.8 62.4 0.0001 
     Microalbuminuria (%) 17.8 23.0 22.2 24.3 <0.0001 
     Overt nephropathy (%) 27.8 17.0 14.1 13.2 0.006 
    Multivariate 1.0 0.7 (0.46–0.99) 0.6 (0.38–0.83) 0.6 (0.43–0.95) — 

Data are odds ratios (95% CI) and are adjusted for age, sex, BMI, WHR, and smoking status. See definition and criteria of diabetic nephropathy in research design and methods. Patients with normoalbuminuria were used as a reference, and the sum of patients with microalbuminuria and overt nephropathy were used as cases.

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