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Table 1

Associations between FTO SNP rs9939609, BMI, and dietary intake in a fixed-effects meta-analysis of 16,097 children and adolescents

Model 1*
Model 2
β (95% CI)PI2β (95% CI)PI2
BMI z score 0.07 (0.05, 0.09) 4.7 × 10−10 40%    
Total energy (kcal/day) 14.6 (6.3, 23.1) 6.5 × 10−4 0% 14.7 (6.3, 23.1) 6.5 × 10−4 6% 
Protein (% of energy) 0.0 (−0.1, 0.0) 0.10 0% 0.0 (−0.1, 0.0) 0.09 0% 
Carbohydrate (% of energy) 0.0 (−0.1, 0.1) 0.96 24% 0.0 (−0.1, 0.1) 0.92 15% 
Fat (% of energy) 0.1 (−0.1, 0.2) 0.40 34% 0.1 (−0.1, 0.2) 0.35 29% 
Model 1*
Model 2
β (95% CI)PI2β (95% CI)PI2
BMI z score 0.07 (0.05, 0.09) 4.7 × 10−10 40%    
Total energy (kcal/day) 14.6 (6.3, 23.1) 6.5 × 10−4 0% 14.7 (6.3, 23.1) 6.5 × 10−4 6% 
Protein (% of energy) 0.0 (−0.1, 0.0) 0.10 0% 0.0 (−0.1, 0.0) 0.09 0% 
Carbohydrate (% of energy) 0.0 (−0.1, 0.1) 0.96 24% 0.0 (−0.1, 0.1) 0.92 15% 
Fat (% of energy) 0.1 (−0.1, 0.2) 0.40 34% 0.1 (−0.1, 0.2) 0.35 29% 

Data are β-coefficients (95% CI) per minor allele of FTO rs9939609 or a proxy (r2 = 1) are given for each trait. Analyses from individual studies were conducted separately and then combined by meta-analysis of 16,097 children and adolescents (15,352 whites, 478 African Americans, and 267 Asians). I2 values are also given.

*Adjusted for age, pubertal status (if available), physical activity (if available), region (if available), and eigenvectors (GWAS data only).

†Further adjusted for BMI based on model 1.

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