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Table 2—

Biochemical and RAS parameters in losartan and placebo groups

Losartan
Placebo
Week 0Week 2Week 4ANOVAWeek 0Week 2Week 4ANOVA
Urinary sodium excretion         
 Regular-sodium diet 255 ± 33 222 ± 23 208 ± 20 NS 208 ± 15 207 ± 27 204 ± 27 NS 
 Low-sodium diet 225 ± 24 226 ± 25 85 ± 14§ <0.0001 205 ± 29 163 ± 17 80 ± 22§ 0.0007 
Fasting plasma glucose (mmol/l)         
 Regular-sodium diet 10.5 ± 1.3 9.8 ± 1.2 9.3 ± 1.2 NS 9.8 ± 1.4 10.7 ± 1.2 9.6 ± 1.4 NS 
 Low-sodium diet 9.1 ± 0.7 8.9 ± 0.7 7.7 ± 0.6* 0.046 9.8 ± 0.7 9.1 ± 0.7 8.5 ± 1.5 NS 
PRA (ng · ml−1 · h−1        
 Regular-sodium diet 0.47 (1.28) 1.31 (1.63) 1.09 (1.52) 0.0004 0.49 (1.31) 0.51 (1.27) 0.43 (1.27) NS 
 Low-sodium diet 0.57 (1.29) 0.99 (1.46) 3.07 (1.63)§ <0.0001 0.57 (1.31) 0.57 (1.3) 0.92 (1.3) <0.01 
Plasma ANG-II (pg/ml)         
 Regular-sodium diet 4.51 (1.24) 8.25 (1.41) 10.04 (1.41) 0.001 6.84 (1.29) 5.82 (1.25) 6.49 (1.21) NS 
 Low-sodium diet 5.65 (1.29) 9.16 (1.4) 24.71 (1.53)§ 0.0002 6.06 (1.19) 6.65 (1.37) 10.8 (1.16)* 0.02 
Plasma aldosterone (pmol/l)         
 Regular-sodium diet 188.1 ± 33.3 273 ± 76.7 190.8 ± 38.7 NS 200.7 ± 43.2 233.4 ± 52.5 208.4 ± 31.4 NS 
 Low-sodium diet 209 ± 32.3 166.9 ± 34.5 345.3 ± 51.5§ 0.0009 173.9 ± 36.8 192 ± 34.5 401 ± 53.4§ <0.0001 
Losartan
Placebo
Week 0Week 2Week 4ANOVAWeek 0Week 2Week 4ANOVA
Urinary sodium excretion         
 Regular-sodium diet 255 ± 33 222 ± 23 208 ± 20 NS 208 ± 15 207 ± 27 204 ± 27 NS 
 Low-sodium diet 225 ± 24 226 ± 25 85 ± 14§ <0.0001 205 ± 29 163 ± 17 80 ± 22§ 0.0007 
Fasting plasma glucose (mmol/l)         
 Regular-sodium diet 10.5 ± 1.3 9.8 ± 1.2 9.3 ± 1.2 NS 9.8 ± 1.4 10.7 ± 1.2 9.6 ± 1.4 NS 
 Low-sodium diet 9.1 ± 0.7 8.9 ± 0.7 7.7 ± 0.6* 0.046 9.8 ± 0.7 9.1 ± 0.7 8.5 ± 1.5 NS 
PRA (ng · ml−1 · h−1        
 Regular-sodium diet 0.47 (1.28) 1.31 (1.63) 1.09 (1.52) 0.0004 0.49 (1.31) 0.51 (1.27) 0.43 (1.27) NS 
 Low-sodium diet 0.57 (1.29) 0.99 (1.46) 3.07 (1.63)§ <0.0001 0.57 (1.31) 0.57 (1.3) 0.92 (1.3) <0.01 
Plasma ANG-II (pg/ml)         
 Regular-sodium diet 4.51 (1.24) 8.25 (1.41) 10.04 (1.41) 0.001 6.84 (1.29) 5.82 (1.25) 6.49 (1.21) NS 
 Low-sodium diet 5.65 (1.29) 9.16 (1.4) 24.71 (1.53)§ 0.0002 6.06 (1.19) 6.65 (1.37) 10.8 (1.16)* 0.02 
Plasma aldosterone (pmol/l)         
 Regular-sodium diet 188.1 ± 33.3 273 ± 76.7 190.8 ± 38.7 NS 200.7 ± 43.2 233.4 ± 52.5 208.4 ± 31.4 NS 
 Low-sodium diet 209 ± 32.3 166.9 ± 34.5 345.3 ± 51.5§ 0.0009 173.9 ± 36.8 192 ± 34.5 401 ± 53.4§ <0.0001 

Data for PRA and ANG-II are geometric means (tolerance factor); data for urinary sodium excretion, fasting plasma glucose, and aldosterone are expressed as means ± SEM.

*

P < 0.05 vs. week 0;

P < 0.01 vs. week 0;

P < 0.05 vs. week 2;

§

P < 0.01 vs. week 2.

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