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Table 4—

Hemodynamic and renal parameters during losartanRS and losartanLS

ParameterLosartanRS
LosartanLS
Δ LosartanLS − Δ losartanRS
P
Week 2Week 4Δ Week 4–2Week 2Week 4ΔWeek 4–2Δ
Blood pressure (mmHg)         
 24-h         
  Systolic 139.6 ± 3.9 139.6 ± 4.8 0 ± 2.1 141.4 ± 4.0 131.7 ± 3.5 −9.7 ± 2.7 −9.7 (−17.2 to −2.2) 0.002 
  Diastolic 77.8 ± 1.5 78.2 ± 1.8 0.4 ± 0.9 78.9 ± 1.2 73.8 ± 1.8 −5.1 ± 1.4 −5.5 (−8.4 to −2.6) 0.002 
  Mean arterial pressure 99.3 ± 1.9 98.9 ± 2.4 −0.4 ± 1.5 100.6 ± 1.8 92.9 ± 1.9 −7.7 ± 1.7 −7.3 (−11.3 to −3.3) 0.003 
 Awake         
  Systolic 142.5 ± 4 142.1 ± 4.9 −0.4 ± 2.2 143.5 ± 4.5 133.6 ± 4.0 −9.9 ± 3.2 −9.5 (−18.4 to −0.6) 0.039 
  Diastolic 80.2 ± 1.6 80.1 ± 1.8 −0.1 ± 0.8 80.7 ± 1.4 75.3 ± 2.0 −5.4 ± 1.8 −5.3 (−9.3 to −1.3) 0.015 
  Mean arterial pressure 101.8 ± 2.1 100.5 ± 2.3 −1.3 ± 1.4 101.1 ± 2.7 94.1 ± 2.4 −7.0 ± 2.6 −5.7 (−11.3 to −0.1) 0.048 
 Sleep         
  Systolic 129.9 ± 3.4 129.6 ± 5.3 −0.3 ± 2.3 134.2 ± 3.7 123.8 ± 3.1 −10.4 ± 3.2 −10.1 (−19.7 to −0.5) 0.041 
  Diastolic 70.3 ± 2.1 70.3 ± 2.2 0 ± 1.8 72.5 ± 1.7 67.7 ± 2.2 −4.8 ± 1.5 −4.8 (−11.2 to 1.5) 0.12 
  Mean arterial pressure 91.4 ± 1.8 91.1 ± 2.9 −0.3 ± 1.9 94.8 ± 1.6 88.2 ± 1.6 −6.6 ± 2.0 −6.3 (−12.8 to 0.8) 0.065 
GFR (ml · min−1 · 1.73m−2101.1 ± 6.1 98.8 ± 6.3 −2.3 ± 2.1 96.9 ± 6.7 91.9 ± 5.9 −5.0 ± 1.7 −2.7 (−8.1 to 2.6) 0.28 
MAG-3 ERPF (ml · min−1 · 1.73 m−2272.9 ± 21.8 267.3 ± 23.4 −5.6 ± 9.9 275.5 ± 20.9 269.2 ± 19.6 −6.3 ± 9.3 −0.7 (−26 to 25) 0.95 
FF (%) 20.1 ± 1.0 20.2 ± 1.3 0.2 ± 1.0 18.8 ± 0.8 18.2 ± 0.6 −0.6 ± 0.4 −0.7 (−3.3 to 1.8) 0.53 
PGC (mmHg) 53.3 ± 3.8 51.9 ± 3.6 −1.4 ± 1.7 54.4 ± 3.9 45.4 ± 4.4 −9.0 ± 1.7 −7.6 (−11.8 to −3.5) 0.002 
ParameterLosartanRS
LosartanLS
Δ LosartanLS − Δ losartanRS
P
Week 2Week 4Δ Week 4–2Week 2Week 4ΔWeek 4–2Δ
Blood pressure (mmHg)         
 24-h         
  Systolic 139.6 ± 3.9 139.6 ± 4.8 0 ± 2.1 141.4 ± 4.0 131.7 ± 3.5 −9.7 ± 2.7 −9.7 (−17.2 to −2.2) 0.002 
  Diastolic 77.8 ± 1.5 78.2 ± 1.8 0.4 ± 0.9 78.9 ± 1.2 73.8 ± 1.8 −5.1 ± 1.4 −5.5 (−8.4 to −2.6) 0.002 
  Mean arterial pressure 99.3 ± 1.9 98.9 ± 2.4 −0.4 ± 1.5 100.6 ± 1.8 92.9 ± 1.9 −7.7 ± 1.7 −7.3 (−11.3 to −3.3) 0.003 
 Awake         
  Systolic 142.5 ± 4 142.1 ± 4.9 −0.4 ± 2.2 143.5 ± 4.5 133.6 ± 4.0 −9.9 ± 3.2 −9.5 (−18.4 to −0.6) 0.039 
  Diastolic 80.2 ± 1.6 80.1 ± 1.8 −0.1 ± 0.8 80.7 ± 1.4 75.3 ± 2.0 −5.4 ± 1.8 −5.3 (−9.3 to −1.3) 0.015 
  Mean arterial pressure 101.8 ± 2.1 100.5 ± 2.3 −1.3 ± 1.4 101.1 ± 2.7 94.1 ± 2.4 −7.0 ± 2.6 −5.7 (−11.3 to −0.1) 0.048 
 Sleep         
  Systolic 129.9 ± 3.4 129.6 ± 5.3 −0.3 ± 2.3 134.2 ± 3.7 123.8 ± 3.1 −10.4 ± 3.2 −10.1 (−19.7 to −0.5) 0.041 
  Diastolic 70.3 ± 2.1 70.3 ± 2.2 0 ± 1.8 72.5 ± 1.7 67.7 ± 2.2 −4.8 ± 1.5 −4.8 (−11.2 to 1.5) 0.12 
  Mean arterial pressure 91.4 ± 1.8 91.1 ± 2.9 −0.3 ± 1.9 94.8 ± 1.6 88.2 ± 1.6 −6.6 ± 2.0 −6.3 (−12.8 to 0.8) 0.065 
GFR (ml · min−1 · 1.73m−2101.1 ± 6.1 98.8 ± 6.3 −2.3 ± 2.1 96.9 ± 6.7 91.9 ± 5.9 −5.0 ± 1.7 −2.7 (−8.1 to 2.6) 0.28 
MAG-3 ERPF (ml · min−1 · 1.73 m−2272.9 ± 21.8 267.3 ± 23.4 −5.6 ± 9.9 275.5 ± 20.9 269.2 ± 19.6 −6.3 ± 9.3 −0.7 (−26 to 25) 0.95 
FF (%) 20.1 ± 1.0 20.2 ± 1.3 0.2 ± 1.0 18.8 ± 0.8 18.2 ± 0.6 −0.6 ± 0.4 −0.7 (−3.3 to 1.8) 0.53 
PGC (mmHg) 53.3 ± 3.8 51.9 ± 3.6 −1.4 ± 1.7 54.4 ± 3.9 45.4 ± 4.4 −9.0 ± 1.7 −7.6 (−11.8 to −3.5) 0.002 

Data expressed as means ± SEM or mean difference (95% CI).

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