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Table 2—

Urinary sodium excretion, urine volume, plasma renin activity, and plasma TGF-β levels in placebo and losartan groups

Placebo
Losartan
Regular sodium
Low sodium
Regular sodium
Low sodium
Week 0Week 4Week 0Week 4Week 0Week 4Week 0Week 4
Urinary Na (mmol/day) 208 ± 15 204 ± 27 205 ± 29 80 ± 22* 225 ± 30 204 ± 19 225 ± 22 91 ± 14* 
Urine volume (ml) 2319 ± 265 2156 ± 204 1967 ± 183 2032 ± 172 2167 ± 288 1986 ± 218 1966 ± 224 1535 ± 121 
PRA (ng · ml−1 · h−10.49 [1.3] 0.43 [1.3] 0.57 [1.3] 0.92 [1.3] 0.41 [1.3] 0.99 [1.5] 0.48 [1.3] 2.68 [1.6]* 
Plasma TGF-β (ng/ml) 2.2 [1.1] 2.0 [1.1] 2.1 [1.1] 2.3 [1.1] 2.0 [1.1] 1.9 [1.1] 2.0 [1.1] 1.9 [1.0] 
Placebo
Losartan
Regular sodium
Low sodium
Regular sodium
Low sodium
Week 0Week 4Week 0Week 4Week 0Week 4Week 0Week 4
Urinary Na (mmol/day) 208 ± 15 204 ± 27 205 ± 29 80 ± 22* 225 ± 30 204 ± 19 225 ± 22 91 ± 14* 
Urine volume (ml) 2319 ± 265 2156 ± 204 1967 ± 183 2032 ± 172 2167 ± 288 1986 ± 218 1966 ± 224 1535 ± 121 
PRA (ng · ml−1 · h−10.49 [1.3] 0.43 [1.3] 0.57 [1.3] 0.92 [1.3] 0.41 [1.3] 0.99 [1.5] 0.48 [1.3] 2.68 [1.6]* 
Plasma TGF-β (ng/ml) 2.2 [1.1] 2.0 [1.1] 2.1 [1.1] 2.3 [1.1] 2.0 [1.1] 1.9 [1.1] 2.0 [1.1] 1.9 [1.0] 

Urinary Na and urine volume are presented as means ± SE; PRA and plasma TGF-β as geometric mean [TF]. P values refer to change from week 0 within each subgroup;

*

P < 0.001,

P < 0.01 vs. week 0.

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