Changes in diabetes medications after 52 weeks of treatment
| . | Placebo . | Orlistat . | P . |
|---|---|---|---|
| n | 269 | 266 | |
| Changes in daily dosages of diabetes medications | |||
| Insulin (units/day) | −1.6 ± 1.7 | −8.1 ± 1.5 | 0.007 |
| Decrease in insulin dose ≥5.0% | 31.0 | 41.2 | 0.0085 |
| Increase in insulin dose ≥5.0% | 25.7 | 11.8 | 0.000 |
| Sulfonylurea (mg/day) | 1.3 ± 4.1 | −7.8 ± 6.2 | 0.037 |
| Metformin (mg/day) | 163 ± 66 | 190+ ± 65 | 0.343 |
| Frequency distribution of medication changes over 52 weeks | 0.000 | ||
| No change in any medications | 37.5 | 44.0 | |
| Decreased dose or discontinued at least one medication | 30.9 | 41.3 | |
| Increased dose or added at least one medication | 31.7 | 14.7 |
| . | Placebo . | Orlistat . | P . |
|---|---|---|---|
| n | 269 | 266 | |
| Changes in daily dosages of diabetes medications | |||
| Insulin (units/day) | −1.6 ± 1.7 | −8.1 ± 1.5 | 0.007 |
| Decrease in insulin dose ≥5.0% | 31.0 | 41.2 | 0.0085 |
| Increase in insulin dose ≥5.0% | 25.7 | 11.8 | 0.000 |
| Sulfonylurea (mg/day) | 1.3 ± 4.1 | −7.8 ± 6.2 | 0.037 |
| Metformin (mg/day) | 163 ± 66 | 190+ ± 65 | 0.343 |
| Frequency distribution of medication changes over 52 weeks | 0.000 | ||
| No change in any medications | 37.5 | 44.0 | |
| Decreased dose or discontinued at least one medication | 30.9 | 41.3 | |
| Increased dose or added at least one medication | 31.7 | 14.7 |
Data are means ± SE or %.