Maternal dietary exposures during pregnancy and risk of IA in offspring
| Parameters (mean daily intake) . | Affected . | Unaffected . | Unadjusted HR (95% CI) . | Wald χ2 P . |
|---|---|---|---|---|
| n | 16 | 206 | ||
| Vitamin D intake via food (IU) | 167.6 | 252.3 | 0.49 (0.26–0.94)* | 0.059 |
| Vitamin D intake via supplements (IU) | ||||
| ≥400 | 13 (81.3) | 116 (56.3) | 3.09 (0.88–10.83) | 0.107 |
| EPA and DHA (ω-3 fatty acids) (g) | ||||
| ≥0.10 | 9 (56.3) | 137 (66.5) | 0.64 (0.24–1.71) | 0.380 |
| Linolenic acid (ω-3 fatty acid) (g) | 1.4 | 1.3 | 1.16 (0.75–1.80)* | 0.503 |
| Arachidonic acid (ω-6 fatty acid) (g) | 0.13 | 0.14 | 0.88 (0.5–1.56)* | 0.672 |
| Linoleic acid (ω-6 fatty acid) (g)† | ||||
| <7.92 | 4 (25.0) | 71 (34.5) | 1.0 (referent) | |
| 7.92–11.78 | 8 (50.0) | 66 (32.0) | 2.01 (0.55–7.37) | 0.274 |
| >11.78 | 4 (25.0) | 69 (33.5) | 1.04 (0.26–4.16) | 0.955 |
| Ratio of ω-6 total:ω-3 total | 7.9 | 7.8 | 1.13 (0.70–1.83)* | 0.624 |
| Caloric intake (kcal)† | ||||
| <1,718.88 | 5 (31.2) | 68 (33.0) | 1.0 (referent) | |
| 1,718.88–2,491.04 | 9 (56.2) | 67 (32.5) | 1.61 (0.54–4.82) | 0.405 |
| >2,491.04 | 2 (12.5) | 71 (34.5) | 0.37 (0.07–1.93) | 0.258 |
| Parameters (mean daily intake) . | Affected . | Unaffected . | Unadjusted HR (95% CI) . | Wald χ2 P . |
|---|---|---|---|---|
| n | 16 | 206 | ||
| Vitamin D intake via food (IU) | 167.6 | 252.3 | 0.49 (0.26–0.94)* | 0.059 |
| Vitamin D intake via supplements (IU) | ||||
| ≥400 | 13 (81.3) | 116 (56.3) | 3.09 (0.88–10.83) | 0.107 |
| EPA and DHA (ω-3 fatty acids) (g) | ||||
| ≥0.10 | 9 (56.3) | 137 (66.5) | 0.64 (0.24–1.71) | 0.380 |
| Linolenic acid (ω-3 fatty acid) (g) | 1.4 | 1.3 | 1.16 (0.75–1.80)* | 0.503 |
| Arachidonic acid (ω-6 fatty acid) (g) | 0.13 | 0.14 | 0.88 (0.5–1.56)* | 0.672 |
| Linoleic acid (ω-6 fatty acid) (g)† | ||||
| <7.92 | 4 (25.0) | 71 (34.5) | 1.0 (referent) | |
| 7.92–11.78 | 8 (50.0) | 66 (32.0) | 2.01 (0.55–7.37) | 0.274 |
| >11.78 | 4 (25.0) | 69 (33.5) | 1.04 (0.26–4.16) | 0.955 |
| Ratio of ω-6 total:ω-3 total | 7.9 | 7.8 | 1.13 (0.70–1.83)* | 0.624 |
| Caloric intake (kcal)† | ||||
| <1,718.88 | 5 (31.2) | 68 (33.0) | 1.0 (referent) | |
| 1,718.88–2,491.04 | 9 (56.2) | 67 (32.5) | 1.61 (0.54–4.82) | 0.405 |
| >2,491.04 | 2 (12.5) | 71 (34.5) | 0.37 (0.07–1.93) | 0.258 |
Data are n (%) unless otherwise indicated.
HR represent risk for an SD difference in intake: SD vitamin D = 155.6 IU; SD linolenic acid = 0.69 g; SD arachidonic acid = 0.08 g; SD ratio ω-6 total to ω-3 total = 2.00;
categorized as tertiles because variable did not meet the assumption of log linearity.