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Table 3—

Baseline (1992) characteristics based on change of glucose status between 1992 and 2000

Baseline CVD risk factors, 1992NGT-NGTNGT-IGTNGT-diabetesIGT-NGTIGT-IGTIGT-diabetesP
NGT-NGT vs. IGT-NGTOverall
n 227 39 12 122 67 102   
Waist (cm) 74.6 ± 0.6 78.7 ± 1.4 83.8 ± 2.4 78.7 ± 0.8 80.2 ± 1.1 84.1 ± 0.9 <0.001 <0.001 
Waist-to-hip ratio 0.79 ± 0.01 0.82 ± 0.01 0.83 ± 0.01 0.81 ± 0.01 0.82 ± 0.01 0.84 ± 0.01 <0.001 <0.001 
BMI (kg/m222.5 ± 0.3 24.7 ± 0.6 26.2 ± 1.1 24.4 ± 0.4 24.7 ± 0.5 26.4 ± 0.4 <0.001 <0.001 
SBP (mmHg) 117 ± 1 123 ± 3 122 ± 4 122 ± 1 125 ± 2 127 ± 2 0.001 <0.001 
DBP (mmHg) 68 ± 1 73 ± 2 74 ± 3 72 ± 1 75 ± 1 76 ± 1 <0.001 <0.001 
Total cholesterol (mmol/l) 5.47 ± 0.06 5.70 ± 0.15 5.46 ± 0.26 5.35 ± 0.09 5.70 ± 0.12 5.61 ± 0.10 0.296 0.153 
Triglyceride (mmol/l) 1.25 ± 0.05 1.58 ± 0.11 1.95 ± 0.19 1.47 ± 0.07 1.65 ± 0.09 1.86 ± 0.08 0.008 <0.001 
LDL cholesterol (mmol/l) 3.63 ± 0.06 3.85 ± 0.14 3.47 ± 0.25 3.48 ± 0.09 3.70 ± 0.12 3.61 ± 0.10 0.156 0.320 
HDL cholesterol (mmol/l) 1.27 ± 0.02 1.13 ± 0.04 1.11 ± 0.08 1.20 ± 0.03 1.25 ± 0.04 1.15 ± 0.03 0.032 0.001 
ApoB 1.32 ± 0.02 1.50 ± 0.05 1.43 ± 0.09 1.33 ± 0.03 1.46 ± 0.04 1.46 ± 0.03 0.974 <0.001 
LDL:apoB ratio 2.77 ± 0.03 2.60 ± 0.06 2.47 ± 0.10 2.62 ± 0.04 2.54 ± 0.05 2.49 ± 0.04 0.002 <0.001 
Insulin resistance 1.50 ± 0.09 1.91 ± 0.19 3.48 ± 0.31 2.27 ± 0.12 2.36 ± 0.15 2.96 ± 0.13 <0.001 <0.001 
Baseline CVD risk factors, 1992NGT-NGTNGT-IGTNGT-diabetesIGT-NGTIGT-IGTIGT-diabetesP
NGT-NGT vs. IGT-NGTOverall
n 227 39 12 122 67 102   
Waist (cm) 74.6 ± 0.6 78.7 ± 1.4 83.8 ± 2.4 78.7 ± 0.8 80.2 ± 1.1 84.1 ± 0.9 <0.001 <0.001 
Waist-to-hip ratio 0.79 ± 0.01 0.82 ± 0.01 0.83 ± 0.01 0.81 ± 0.01 0.82 ± 0.01 0.84 ± 0.01 <0.001 <0.001 
BMI (kg/m222.5 ± 0.3 24.7 ± 0.6 26.2 ± 1.1 24.4 ± 0.4 24.7 ± 0.5 26.4 ± 0.4 <0.001 <0.001 
SBP (mmHg) 117 ± 1 123 ± 3 122 ± 4 122 ± 1 125 ± 2 127 ± 2 0.001 <0.001 
DBP (mmHg) 68 ± 1 73 ± 2 74 ± 3 72 ± 1 75 ± 1 76 ± 1 <0.001 <0.001 
Total cholesterol (mmol/l) 5.47 ± 0.06 5.70 ± 0.15 5.46 ± 0.26 5.35 ± 0.09 5.70 ± 0.12 5.61 ± 0.10 0.296 0.153 
Triglyceride (mmol/l) 1.25 ± 0.05 1.58 ± 0.11 1.95 ± 0.19 1.47 ± 0.07 1.65 ± 0.09 1.86 ± 0.08 0.008 <0.001 
LDL cholesterol (mmol/l) 3.63 ± 0.06 3.85 ± 0.14 3.47 ± 0.25 3.48 ± 0.09 3.70 ± 0.12 3.61 ± 0.10 0.156 0.320 
HDL cholesterol (mmol/l) 1.27 ± 0.02 1.13 ± 0.04 1.11 ± 0.08 1.20 ± 0.03 1.25 ± 0.04 1.15 ± 0.03 0.032 0.001 
ApoB 1.32 ± 0.02 1.50 ± 0.05 1.43 ± 0.09 1.33 ± 0.03 1.46 ± 0.04 1.46 ± 0.03 0.974 <0.001 
LDL:apoB ratio 2.77 ± 0.03 2.60 ± 0.06 2.47 ± 0.10 2.62 ± 0.04 2.54 ± 0.05 2.49 ± 0.04 0.002 <0.001 
Insulin resistance 1.50 ± 0.09 1.91 ± 0.19 3.48 ± 0.31 2.27 ± 0.12 2.36 ± 0.15 2.96 ± 0.13 <0.001 <0.001 

Data are means ± SE. Groups are named on the basis of baseline glucose tolerance (1992) followed by glucose tolerance on follow-up examination (2000). Analysis utilized ANCOVA adjusted for age and sex. Pairwise comparison between groups was carried out using the least square difference method. This table excludes 26 of the initial 595 subjects. Eight subjects were excluded because of incomplete data for fasting or 2-h postload glucose. A further 18 subjects with impaired fasting glycemia but not IGT at baseline or on follow-up were also excluded. ApoB, apolipoprotein B-100; DBP, diastolic blood pressure; SBP, systolic blood pressure.

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