Effectiveness of lipid-lowering treatment by LDL cholesterol level and statin
| . | Lipid-lowering effect (%) . | Decrease in LDL (mg/dl) . | LDL achieved with treatment (mg/dl) . | Cardiac events prevented per year*† . |
|---|---|---|---|---|
| LDL C level 100–129 mg/dl | ||||
| Atorvastatin 10 mg | 26 | 26–34 | 95–74 | 13,000 |
| Simvastatin 10 mg | 27 | 27–35 | 94–73 | 13,500 |
| Lovastatin 20 mg | 25 | 25–32 | 97–75 | 12,500 |
| Fluvastatin 40 mg | 25 | 25–32 | 97–75 | 12,500 |
| Pravastatin 20 mg | 24 | 24–31 | 98–76 | 12,000 |
| LDL C level 130–149 mg/dl | ||||
| Atorvastatin 20 mg | 39 | 51–58 | 91–79 | 18,500 |
| Simvastatin 20 mg | 33 | 43–49 | 100–87 | 15,300 |
| Lovastatin 40 mg | 30 | 39–45 | 104–91 | 13,800 |
| Fluvastatin 80 mg | 32 | 42–48 | 101–88 | 14,800 |
| Pravastatin 40 mg | 29 | 38–43 | 106–92 | 13,200 |
| LDL C level 150–169 mg/dl | ||||
| Atorvastatin 20 mg | 39 | 59–66 | 103–92 | 21,400 |
| Simvastatin 40 mg | 38 | 57–64 | 105–93 | 20,800 |
| Lovastatin 80 mg | 36 | 54–61 | 108–96 | 19,500 |
| LDL C level 170–189 mg/dl | ||||
| Atorvastatin 40 mg | 47 | 80–89 | 100–90 | 9,000 |
| Simvastatin 80 mg | 44 | 75–83 | 106–95 | 8,300 |
| LDL C level 190–209 mg/dl | ||||
| Atorvastatin 80 mg | 47 | 89–98 | 111–101 | 9,500 |
| . | Lipid-lowering effect (%) . | Decrease in LDL (mg/dl) . | LDL achieved with treatment (mg/dl) . | Cardiac events prevented per year*† . |
|---|---|---|---|---|
| LDL C level 100–129 mg/dl | ||||
| Atorvastatin 10 mg | 26 | 26–34 | 95–74 | 13,000 |
| Simvastatin 10 mg | 27 | 27–35 | 94–73 | 13,500 |
| Lovastatin 20 mg | 25 | 25–32 | 97–75 | 12,500 |
| Fluvastatin 40 mg | 25 | 25–32 | 97–75 | 12,500 |
| Pravastatin 20 mg | 24 | 24–31 | 98–76 | 12,000 |
| LDL C level 130–149 mg/dl | ||||
| Atorvastatin 20 mg | 39 | 51–58 | 91–79 | 18,500 |
| Simvastatin 20 mg | 33 | 43–49 | 100–87 | 15,300 |
| Lovastatin 40 mg | 30 | 39–45 | 104–91 | 13,800 |
| Fluvastatin 80 mg | 32 | 42–48 | 101–88 | 14,800 |
| Pravastatin 40 mg | 29 | 38–43 | 106–92 | 13,200 |
| LDL C level 150–169 mg/dl | ||||
| Atorvastatin 20 mg | 39 | 59–66 | 103–92 | 21,400 |
| Simvastatin 40 mg | 38 | 57–64 | 105–93 | 20,800 |
| Lovastatin 80 mg | 36 | 54–61 | 108–96 | 19,500 |
| LDL C level 170–189 mg/dl | ||||
| Atorvastatin 40 mg | 47 | 80–89 | 100–90 | 9,000 |
| Simvastatin 80 mg | 44 | 75–83 | 106–95 | 8,300 |
| LDL C level 190–209 mg/dl | ||||
| Atorvastatin 80 mg | 47 | 89–98 | 111–101 | 9,500 |
Data adapted from reference 14.
Cardiac events prevented per year are rounded to nearest 100 and were calculated from the HPS and the UKPDS;
cardiac events per year without statin treatment by baseline LDL cholesterol levels are as follows: 100–129 mg/dl: 44,400; 130–149 mg/dl: 41,700; 150–169 mg/dl: 49,900; 170–189 mg/dl: 17,400; ≥190 mg/dl: 18,800. C, cholesterol.