Skip to Main Content
Table 1—

Effectiveness of lipid-lowering treatment by LDL cholesterol level and statin

Lipid-lowering effect (%)Decrease in LDL (mg/dl)LDL achieved with treatment (mg/dl)Cardiac events prevented per year*
LDL C level 100–129 mg/dl     
 Atorvastatin 10 mg 26 26–34 95–74 13,000 
 Simvastatin 10 mg 27 27–35 94–73 13,500 
 Lovastatin 20 mg 25 25–32 97–75 12,500 
 Fluvastatin 40 mg 25 25–32 97–75 12,500 
 Pravastatin 20 mg 24 24–31 98–76 12,000 
LDL C level 130–149 mg/dl     
 Atorvastatin 20 mg 39 51–58 91–79 18,500 
 Simvastatin 20 mg 33 43–49 100–87 15,300 
 Lovastatin 40 mg 30 39–45 104–91 13,800 
 Fluvastatin 80 mg 32 42–48 101–88 14,800 
 Pravastatin 40 mg 29 38–43 106–92 13,200 
LDL C level 150–169 mg/dl     
 Atorvastatin 20 mg 39 59–66 103–92 21,400 
 Simvastatin 40 mg 38 57–64 105–93 20,800 
 Lovastatin 80 mg 36 54–61 108–96 19,500 
LDL C level 170–189 mg/dl     
 Atorvastatin 40 mg 47 80–89 100–90 9,000 
 Simvastatin 80 mg 44 75–83 106–95 8,300 
LDL C level 190–209 mg/dl     
 Atorvastatin 80 mg 47 89–98 111–101 9,500 
Lipid-lowering effect (%)Decrease in LDL (mg/dl)LDL achieved with treatment (mg/dl)Cardiac events prevented per year*
LDL C level 100–129 mg/dl     
 Atorvastatin 10 mg 26 26–34 95–74 13,000 
 Simvastatin 10 mg 27 27–35 94–73 13,500 
 Lovastatin 20 mg 25 25–32 97–75 12,500 
 Fluvastatin 40 mg 25 25–32 97–75 12,500 
 Pravastatin 20 mg 24 24–31 98–76 12,000 
LDL C level 130–149 mg/dl     
 Atorvastatin 20 mg 39 51–58 91–79 18,500 
 Simvastatin 20 mg 33 43–49 100–87 15,300 
 Lovastatin 40 mg 30 39–45 104–91 13,800 
 Fluvastatin 80 mg 32 42–48 101–88 14,800 
 Pravastatin 40 mg 29 38–43 106–92 13,200 
LDL C level 150–169 mg/dl     
 Atorvastatin 20 mg 39 59–66 103–92 21,400 
 Simvastatin 40 mg 38 57–64 105–93 20,800 
 Lovastatin 80 mg 36 54–61 108–96 19,500 
LDL C level 170–189 mg/dl     
 Atorvastatin 40 mg 47 80–89 100–90 9,000 
 Simvastatin 80 mg 44 75–83 106–95 8,300 
LDL C level 190–209 mg/dl     
 Atorvastatin 80 mg 47 89–98 111–101 9,500 

Data adapted from reference 14.

*

Cardiac events prevented per year are rounded to nearest 100 and were calculated from the HPS and the UKPDS;

cardiac events per year without statin treatment by baseline LDL cholesterol levels are as follows: 100–129 mg/dl: 44,400; 130–149 mg/dl: 41,700; 150–169 mg/dl: 49,900; 170–189 mg/dl: 17,400; ≥190 mg/dl: 18,800. C, cholesterol.

Close Modal

or Create an Account

Close Modal
Close Modal