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Table 3—

Multivariate analysis using stepwise linear regressions of statistically significant CGE variables at baseline and averaged over time, and severity of microvessel complications at first and last evaluation in the RDNS cohort

Microvessel complication and type of diabetesPartial R2
CGE variable at first examination
CGE variable averaged over time (A1C) or at last visit (duration of diabetes, age at onset of diabetes): microvessel complication at last examination
Microvessel complication at first examination
Microvessel complication at last examination
GEiDuration of diabetesAge at onset of diabetesGEiA1CDuration of diabetesAge at onset of diabetesGEiA1CDuration of diabetesAge at onset of diabetes
Polyneuropathy            
    Σ 5 NC nds            
        All 0.24  0.03 0.25    0.28    
        Type 1 0.34   0.25    0.42    
        Type 2 0.14   0.13    0.14    
    Stage severity            
        All 0.15  0.03 0.12 0.02   0.13    
        Type 1 0.22     0.16  0.28    
        Type 2 0.06   0.05   0.02 0.05    
Neuropathy staged severity            
    All 0.06   0.01 0.05  0.03  0.06  0.02 
    Type 1 0.15    0.08    0.12  0.03 
    Type 2 0.09    0.08   0.08    
Retinopathy staged severity            
    All  0.33 0.04 0.23 0.02   0.31 0.01   
    Type 1  0.48    0.12  0.43  0.03  
    Type 2  0.16  0.13    0.20    
Microvessel complication and type of diabetesPartial R2
CGE variable at first examination
CGE variable averaged over time (A1C) or at last visit (duration of diabetes, age at onset of diabetes): microvessel complication at last examination
Microvessel complication at first examination
Microvessel complication at last examination
GEiDuration of diabetesAge at onset of diabetesGEiA1CDuration of diabetesAge at onset of diabetesGEiA1CDuration of diabetesAge at onset of diabetes
Polyneuropathy            
    Σ 5 NC nds            
        All 0.24  0.03 0.25    0.28    
        Type 1 0.34   0.25    0.42    
        Type 2 0.14   0.13    0.14    
    Stage severity            
        All 0.15  0.03 0.12 0.02   0.13    
        Type 1 0.22     0.16  0.28    
        Type 2 0.06   0.05   0.02 0.05    
Neuropathy staged severity            
    All 0.06   0.01 0.05  0.03  0.06  0.02 
    Type 1 0.15    0.08    0.12  0.03 
    Type 2 0.09    0.08   0.08    
Retinopathy staged severity            
    All  0.33 0.04 0.23 0.02   0.31 0.01   
    Type 1  0.48    0.12  0.43  0.03  
    Type 2  0.16  0.13    0.20    

All listed results have P < 0.05. Results in boldface indicate P < 0.001.

* FPG or A1C was averaged over time as described in research design and methods. Duration of diabetes (years) was assessed at the first or last examination. Age of onset is given in years.

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