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Table 1—

Clinical characteristics at baseline and 1 year of weight loss intervention

Orlistat + intervention
Placebo + intervention
BaselineYear 1BaselineYear 1
n 17  21  
Weight (kg) 97.0 ± 15.1 86.9 ± 13* 101.8 ± 19.3 92.4 ± 16.4* 
BMI (kg/m234.0 ± 5.2 30.4 ± 4.1* 37.0 ± 8.1 33.6 ± 7.2* 
Fasting plasma glucose (mg/dl) 182 ± 52 138 ± 46 154 ± 43 119 ± 20 
A1C (%) 8.1 ± 1.2 6.7 ± 1.0* 7.8 ± 1.5 6.6 ± 1.1 
Fasting plasma insulin (μU/ml) 20.7 ± 2.9 20.2 ± 3.8 26.6 ± 4.0 25.8 ± 3.8 
Systolic blood pressure (mmHg) 127 ± 15 131 ± 17 131 ± 15 128 ± 19 
Diastolic blood pressure (mmHg) 80 ± 8 78 ± 6 81 ± 12 81 ± 8 
LDL cholesterol (mg/dl) 130 ± 35 114 ± 37 129 ± 27 120 ± 27 
HDL cholesterol (mg/dl) 44 ± 10 49 ± 13 47 ± 11 56 ± 14* 
Orlistat + intervention
Placebo + intervention
BaselineYear 1BaselineYear 1
n 17  21  
Weight (kg) 97.0 ± 15.1 86.9 ± 13* 101.8 ± 19.3 92.4 ± 16.4* 
BMI (kg/m234.0 ± 5.2 30.4 ± 4.1* 37.0 ± 8.1 33.6 ± 7.2* 
Fasting plasma glucose (mg/dl) 182 ± 52 138 ± 46 154 ± 43 119 ± 20 
A1C (%) 8.1 ± 1.2 6.7 ± 1.0* 7.8 ± 1.5 6.6 ± 1.1 
Fasting plasma insulin (μU/ml) 20.7 ± 2.9 20.2 ± 3.8 26.6 ± 4.0 25.8 ± 3.8 
Systolic blood pressure (mmHg) 127 ± 15 131 ± 17 131 ± 15 128 ± 19 
Diastolic blood pressure (mmHg) 80 ± 8 78 ± 6 81 ± 12 81 ± 8 
LDL cholesterol (mg/dl) 130 ± 35 114 ± 37 129 ± 27 120 ± 27 
HDL cholesterol (mg/dl) 44 ± 10 49 ± 13 47 ± 11 56 ± 14* 

Data are means ± SD.

*

P < 0.01,

P < 0.05 year 1 vs. baseline.

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