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Table 2—

Costs of DPN and its complications in the U.S.

Health stateEstimated cost ($)References
 Mean weekly cost  
Painful symptomatic DPN $5.90* (12) 
Foot ulcer   
Not infected $178.97 (12) 
With cellulitis $472.73 (12) 
With osteomyelitis $876.52 (11, 12) 
 Total event cost  
Amputation   
Toe $22,702.65 (11) 
Foot $42,673.04 (11) 
Leg $51,280.94 (11) 
Health stateEstimated cost ($)References
 Mean weekly cost  
Painful symptomatic DPN $5.90* (12) 
Foot ulcer   
Not infected $178.97 (12) 
With cellulitis $472.73 (12) 
With osteomyelitis $876.52 (11, 12) 
 Total event cost  
Amputation   
Toe $22,702.65 (11) 
Foot $42,673.04 (11) 
Leg $51,280.94 (11) 

Price year: 2001.

*

Typical weekly cost of a tricyclic antidepressant.

Gauze dressing two times a day. Mean numbers of weekly outpatient clinic attendances: 0.5 (no deep infection), one (with cellulitis), and 1.5 (with osteomyelitis). Proportions of patients receiving nurse home visits: 25% (no deep infection), 50% (with cellulitis), and 75% (with osteomyelitis). Mean numbers of weekly nurse home visits: three (no deep infection) and five (with cellulitis or osteomyelitis). Drugs received: cephalexin (500 mg four times a day; 50% of patients with no deep infection), clindamycin (300 mg three times a day; 50% of patients with no deep infection and all patients with a foot ulcer accompanied by cellulitis or osteomyelitis), and ciprofloxacin (500 mg two times a day; all patients with a foot ulcer accompanied by cellulitis, 400 mg two times a day; all patients with a foot ulcer accompanied by osteomyelitis).

Assumed cost of prosthetic leg: $15,000.

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