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Table 1—

Changes in body composition, regional fat, muscle lipid, and serum lipids during the exercise program

BaselineTwo to four boutsProgram end
Anthropometry    
 Weight (kg) 94.1 ± 2.0 94.1 ± 2.0 92.8 ± 2.0 
 BMI (kg/m230.9 ± 0.7 30.8 ± 0.7 30.4 ± 0.8 
 Waist (cm) 105.0 ± 1.5 105.0 ± 1.5 103.0 ± 2.0* 
DXA    
 FFM (kg)    
  Total 62.0 ± 1.3 — 62.6 ± 1.3 
  Limb 29.5 ± 0.7 — 30.1 ± 0.8* 
 Fat (kg)    
  Total 32.3 ± 1.5 — 30.9 ± 1.5* 
  Central abdominal 2.37 ± 0.10 — 2.25 ± 0.10* 
  Limb 13.2 ± 0.7 — 12.8 ± 0.7 
 Central abdominal–to–limb fat ratio 0.184 ± 0.008 — 0.181 ± 0.008 
Abdominal MRI    
 TAT (l) 6.11 ± 0.32 — 5.81 ± 0.34* 
 SAT (l) 3.88 ± 0.31 — 3.70 ± 0.31* 
 VAT (l) 2.23 ± 0.12 — 2.11 ± 0.12 
 VAT-to-SAT ratio 0.63 ± 0.05 — 0.62 ± 0.05 
 VAT–to–limb fat ratio (ml/g) 0.178 ± 0.014 — 0.173 ± 0.013 
Serum lipids    
 Total cholesterol (mmol/l) 4.84 ± 0.22 4.63 ± 0.21 4.35 ± 0.21* 
 HDL cholesterol (mmol/l) 0.77 ± 0.04 0.78 ± 0.04 0.81 ± 0.05 
 Triglycerides (mmol/l) 2.35 ± 0.59 1.60 ± 0.22§ 1.50 ± 0.15 
 Free fatty acids (mmol/l) 0.42 ± 0.03 0.42 ± 0.02 0.45 ± 0.03 
 Apolipoprotein B (g/l) 1.07 ± 0.05 NA 1.03 ± 0.05 
1H-MRS    
 Intramyocellular lipid (IMCH2-to-  creatine ratio)    
  Soleus 11.1 ± 0.8 11.7 ± 0.8 11.6 ± 0.8 
  Tibialis anterior 6.1 ± 0.8 5.7 ± 0.8 5.5 ± 0.7 
Vastus lateralis biopsy    
 Muscle triglyceride (μmol/g dry wt) 36.6 ± 4.9 27.5 ± 3.3 28.9 ± 3.8 
 Muscle LCAC (nmol/g wet wt) 3.77 ± 0.29 3.44 ± 0.27 3.26 ± 0.33 
BaselineTwo to four boutsProgram end
Anthropometry    
 Weight (kg) 94.1 ± 2.0 94.1 ± 2.0 92.8 ± 2.0 
 BMI (kg/m230.9 ± 0.7 30.8 ± 0.7 30.4 ± 0.8 
 Waist (cm) 105.0 ± 1.5 105.0 ± 1.5 103.0 ± 2.0* 
DXA    
 FFM (kg)    
  Total 62.0 ± 1.3 — 62.6 ± 1.3 
  Limb 29.5 ± 0.7 — 30.1 ± 0.8* 
 Fat (kg)    
  Total 32.3 ± 1.5 — 30.9 ± 1.5* 
  Central abdominal 2.37 ± 0.10 — 2.25 ± 0.10* 
  Limb 13.2 ± 0.7 — 12.8 ± 0.7 
 Central abdominal–to–limb fat ratio 0.184 ± 0.008 — 0.181 ± 0.008 
Abdominal MRI    
 TAT (l) 6.11 ± 0.32 — 5.81 ± 0.34* 
 SAT (l) 3.88 ± 0.31 — 3.70 ± 0.31* 
 VAT (l) 2.23 ± 0.12 — 2.11 ± 0.12 
 VAT-to-SAT ratio 0.63 ± 0.05 — 0.62 ± 0.05 
 VAT–to–limb fat ratio (ml/g) 0.178 ± 0.014 — 0.173 ± 0.013 
Serum lipids    
 Total cholesterol (mmol/l) 4.84 ± 0.22 4.63 ± 0.21 4.35 ± 0.21* 
 HDL cholesterol (mmol/l) 0.77 ± 0.04 0.78 ± 0.04 0.81 ± 0.05 
 Triglycerides (mmol/l) 2.35 ± 0.59 1.60 ± 0.22§ 1.50 ± 0.15 
 Free fatty acids (mmol/l) 0.42 ± 0.03 0.42 ± 0.02 0.45 ± 0.03 
 Apolipoprotein B (g/l) 1.07 ± 0.05 NA 1.03 ± 0.05 
1H-MRS    
 Intramyocellular lipid (IMCH2-to-  creatine ratio)    
  Soleus 11.1 ± 0.8 11.7 ± 0.8 11.6 ± 0.8 
  Tibialis anterior 6.1 ± 0.8 5.7 ± 0.8 5.5 ± 0.7 
Vastus lateralis biopsy    
 Muscle triglyceride (μmol/g dry wt) 36.6 ± 4.9 27.5 ± 3.3 28.9 ± 3.8 
 Muscle LCAC (nmol/g wet wt) 3.77 ± 0.29 3.44 ± 0.27 3.26 ± 0.33 

Data are mean ± SE.

*

P < 0.05 for program end vs. baseline;

P < 0.05 for program end vs. two to four bouts;

serum triglycerides were log-transformed for statistical tests;

§

P < 0.05 for two to four bouts vs. baseline.

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