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Table 1—

Clinical data for 38 insulin-treated patients with CF-related diabetes with or without lung transplantation

Nontransplant patientsTransplant patients
n 29 
Sex (male/female) 14/15 4/5 
Age (years) 29 (18–55) 37 (25–48) 
BMI (kg/m220.6 (17–32.9) 20.7 (17.6–24.2) 
Prednisolone treatment 
FEV 61 (28–111) 84 (35–119) 
FVC 86 (59–126) 101 (56–125) 
Duration of diabetes (years) 12 (0–31) 13 (3–22) 
Insulin (IU/day) 26 (4–96) 24 (16–57) 
A1C (%) 6.9 (5.7–11.2) 7.1 (5.4–8.3) 
Mild and moderate retinopathy 5 (21) 2 (22) 
Proliferative retinopathy 1 (4) 1 (11) 
Hypertension 9 (31) 8 (89) 
Microalbuminuria (30–300 mg/24 h) 3 (13) 2 (22) 
Macroalbuminuria (>300 mg/24 h) 
Serum creatinine > 110 μmol/l 1 (4) 7 (78) 
GFR (ml/min per 1.73 m2102 (64–152) 35 (20–73)* 
Total cholesterol 3.7 (2.3–4.8) 4.6 (4.2–6.1) 
Pulsation of dorsalis pedis artery 28 (100) 8 (100) 
Threshold of vibration at the index toe >20 0 (0) 3 (33) 
Nontransplant patientsTransplant patients
n 29 
Sex (male/female) 14/15 4/5 
Age (years) 29 (18–55) 37 (25–48) 
BMI (kg/m220.6 (17–32.9) 20.7 (17.6–24.2) 
Prednisolone treatment 
FEV 61 (28–111) 84 (35–119) 
FVC 86 (59–126) 101 (56–125) 
Duration of diabetes (years) 12 (0–31) 13 (3–22) 
Insulin (IU/day) 26 (4–96) 24 (16–57) 
A1C (%) 6.9 (5.7–11.2) 7.1 (5.4–8.3) 
Mild and moderate retinopathy 5 (21) 2 (22) 
Proliferative retinopathy 1 (4) 1 (11) 
Hypertension 9 (31) 8 (89) 
Microalbuminuria (30–300 mg/24 h) 3 (13) 2 (22) 
Macroalbuminuria (>300 mg/24 h) 
Serum creatinine > 110 μmol/l 1 (4) 7 (78) 
GFR (ml/min per 1.73 m2102 (64–152) 35 (20–73)* 
Total cholesterol 3.7 (2.3–4.8) 4.6 (4.2–6.1) 
Pulsation of dorsalis pedis artery 28 (100) 8 (100) 
Threshold of vibration at the index toe >20 0 (0) 3 (33) 

Data are median (range) or n (%). Eye data was available from all 9 of the transplant patients and in 24 of 29 nontransplant patients (diabetes duration 0–17 years). Data on pulsation of dorsalis pedis artery was available in 8 transplant and 28 nontransplant patients.

*

P < 0.0005, n = 24 (nontransplant) and n = 8 (transplant). FEV, forced expiratory volume; FVC, forced vital capacity; GFR, glomerular filtration rate.

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