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Table 2—

Adjusted insulin resistance measures by PLIN 11482G→A genotypes, sex, and ethnicity in a Singapore population

Men
P*Women
P*
GGGAAAGGGAAA
Chinese         
    n 436 605 222  526 728 246  
    Fasting glucose (mmol/l) 5.80 ± 0.05 5.80 ± 0.04 5.73 ± 0.06 0.597 5.46 ± 0.05 5.53 ± 0.04 5.47 ± 0.07 0.435 
    2-h glucose (mmol/l) 6.64 ± 0.12 6.50 ± 0.10 6.56 ± 0.17 0.924 6.57 ± 0.11 6.86 ± 0.10 6.72 ± 0.17 0.213 
    Fasting insulin (mU/l) 8.57 ± 0.78 7.52 ± 0.66 7.34 ± 1.10 0.400 7.08 ± 0.17 7.08 ± 0.14 6.88 ± 0.25 0.807 
    2-h insulin (mU/l) 57.74 ± 2.60 55.15 ± 2.21 50.71 ± 3.63 0.600 61.38 ± 2.24 62.89 ± 1.90 57.14 ± 3.27 0.621 
    HOMA-IR 1.82 ± 0.0 1.91 ± 0.04 1.81 ± 0.07 0.342 1.71 ± 0.05 1.74 ± 0.04 1.70 ± 0.07 0.672 
Malay         
    n 116 177 67  113 202 71  
    Fasting glucose (mmol/l) 6.22 ± 0.14 6.04 ± 0.12 6.14 ± 0.19 0.354 6.28 ± 0.18 6.22 ± 0.13 5.70 ± 0.22 0.171 
    2-h glucose (mmol/l) 7.50 ± 0.29 7.08 ± 0.23 7.26 ± 0.39 0.818 7.61 ± 0.32 7.90 ± 0.24 7.05 ± 0.43 0.348 
    Fasting insulin (mU/l) 7.74 ± 0.49 8.16 ± 0.39 8.60 ± 0.64 0.563 9.96 ± 0.65 9.55 ± 0.49 9.21 ± 0.83 0.450 
    2-h insulin (mU/l) 65.18 ± 6.80 73.31 ± 5.38 64.48 ± 8.85 0.546 74.70 ± 5.53 76.74 ± 4.22 74.87 ± 7.47 0.777 
    HOMA-IR 2.18 ± 0.15) 2.11 ± 0.12 2.32 ± 0.20 0.520 2.59 ± 0.20 2.56 ± 0.15 2.33 ± 0.27 0.429 
Indian         
    n 135 126 25  128 154 30  
    Fasting glucose (mmol/l) 6.23 ± 0.17 6.68 ± 0.17 6.30 ± 0.39 0.107 6.11 ± 0.15 6.10 ± 0.13 6.06 ± 0.30 0.978 
    2-h glucose (mmol/l) 7.15 ± 0.33 8.15 ± 0.34 6.22 ± 0.83 0.083 7.52 ± 0.34 7.88 ± 0.30 7.89 ± 0.70 0.564 
    Fasting insulin (mU/l) 10.60 ± 0.75 10.86 ± 0.78 8.46 ± 1.77 0.473 11.40 ± 0.49 10.74 ± 0.45 11.14 ± 1.02 0.772 
    2-h insulin (mU/l) 87.45 ± 7.87 91.18 ± 8.14 68.09 ± 19.83 0.470 92.49 ± 6.72 89.86 ± 6.04 99.33 ± 13.93 0.490 
    HOMA-IR 2.90 ± 0.27 3.03 ± 0.28 1.88 ± 0.68 0.282 2.88 ± 0.16 2.81 ± 0.15 3.12 ± 0.35 0.545 
Men
P*Women
P*
GGGAAAGGGAAA
Chinese         
    n 436 605 222  526 728 246  
    Fasting glucose (mmol/l) 5.80 ± 0.05 5.80 ± 0.04 5.73 ± 0.06 0.597 5.46 ± 0.05 5.53 ± 0.04 5.47 ± 0.07 0.435 
    2-h glucose (mmol/l) 6.64 ± 0.12 6.50 ± 0.10 6.56 ± 0.17 0.924 6.57 ± 0.11 6.86 ± 0.10 6.72 ± 0.17 0.213 
    Fasting insulin (mU/l) 8.57 ± 0.78 7.52 ± 0.66 7.34 ± 1.10 0.400 7.08 ± 0.17 7.08 ± 0.14 6.88 ± 0.25 0.807 
    2-h insulin (mU/l) 57.74 ± 2.60 55.15 ± 2.21 50.71 ± 3.63 0.600 61.38 ± 2.24 62.89 ± 1.90 57.14 ± 3.27 0.621 
    HOMA-IR 1.82 ± 0.0 1.91 ± 0.04 1.81 ± 0.07 0.342 1.71 ± 0.05 1.74 ± 0.04 1.70 ± 0.07 0.672 
Malay         
    n 116 177 67  113 202 71  
    Fasting glucose (mmol/l) 6.22 ± 0.14 6.04 ± 0.12 6.14 ± 0.19 0.354 6.28 ± 0.18 6.22 ± 0.13 5.70 ± 0.22 0.171 
    2-h glucose (mmol/l) 7.50 ± 0.29 7.08 ± 0.23 7.26 ± 0.39 0.818 7.61 ± 0.32 7.90 ± 0.24 7.05 ± 0.43 0.348 
    Fasting insulin (mU/l) 7.74 ± 0.49 8.16 ± 0.39 8.60 ± 0.64 0.563 9.96 ± 0.65 9.55 ± 0.49 9.21 ± 0.83 0.450 
    2-h insulin (mU/l) 65.18 ± 6.80 73.31 ± 5.38 64.48 ± 8.85 0.546 74.70 ± 5.53 76.74 ± 4.22 74.87 ± 7.47 0.777 
    HOMA-IR 2.18 ± 0.15) 2.11 ± 0.12 2.32 ± 0.20 0.520 2.59 ± 0.20 2.56 ± 0.15 2.33 ± 0.27 0.429 
Indian         
    n 135 126 25  128 154 30  
    Fasting glucose (mmol/l) 6.23 ± 0.17 6.68 ± 0.17 6.30 ± 0.39 0.107 6.11 ± 0.15 6.10 ± 0.13 6.06 ± 0.30 0.978 
    2-h glucose (mmol/l) 7.15 ± 0.33 8.15 ± 0.34 6.22 ± 0.83 0.083 7.52 ± 0.34 7.88 ± 0.30 7.89 ± 0.70 0.564 
    Fasting insulin (mU/l) 10.60 ± 0.75 10.86 ± 0.78 8.46 ± 1.77 0.473 11.40 ± 0.49 10.74 ± 0.45 11.14 ± 1.02 0.772 
    2-h insulin (mU/l) 87.45 ± 7.87 91.18 ± 8.14 68.09 ± 19.83 0.470 92.49 ± 6.72 89.86 ± 6.04 99.33 ± 13.93 0.490 
    HOMA-IR 2.90 ± 0.27 3.03 ± 0.28 1.88 ± 0.68 0.282 2.88 ± 0.16 2.81 ± 0.15 3.12 ± 0.35 0.545 

Data are means ± SE.

*

Test for homogenesis across genotypes. Means were adjusted for age, BMI, smoking, alcohol intake, physical activity, and diabetes status.

After the collection of the fasting sample, a 75-g oral glucose tolerance test was taken. After 2 h, a blood sample was obtained and glucose (2-h glucose) and insulin (2-h insulin) were measured. These tests were not carried out in diabetic subjects on medication (68 men: 34 Chinese, 13 Malays, and 21 Asian Indians; and 65 women: 24 Chinese, 22 Malays, and 22 Asian Indians).

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