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Table 3—

Interactions between PLIN 11482G→A and PLIN 14995A→T polymorphisms and intakes of total fat, SFAs, and carbohydrate in determining plasma insulin resistance–related measures in Singapore women (Chinese, Malay, and Asian Indian)

PolymorphismGenotypes*Tertiles
P trendP interaction
1 (n = 384)2 (n = 385)3 (n = 384)
Total fat (tertiles of intake, %)   7.1–25.2 25.2–29.8 29.8–54.1   
    Fasting glucose (mmol/l) 11482G→A GG + GA 5.62 ± 0.08 5.60 ± 0.07 5.68 ± 0.07 0.713 0.425 
  AA 5.41 ± 0.15 5.56 ± 0.14 5.62 ± 0.13 0.327  
    Fasting insulin (mU/l)  GG + GA 8.62 ± 0.31 8.16 ± 0.29 8.31 ± 0.30 0.824 0.010 
  AA 7.53 ± 0.62 8.10 ± 0.62 9.31 ± 0.59 0.134  
    HOMA-IR  GG + GA 2.23 ± 0.09 2.10 ± 0.08 2.19 ± 0.08 0.737 0.007 
  AA 1.89 ± 0.18 2.10 ± 0.17 2.41 ± 0.17 0.104  
    Fasting glucose (mmol/l) 14995A→T AA + AT 5.58 ± 0.07 5.56 ± 0.07 5.69 ± 0.07 0.338 0.448 
  TT 5.55 ± 0.14 5.58 ± 0.14 5.63 ± 0.12 0.574  
    Fasting insulin (mU/l)  AA + AT 8.58 ± 0.28 8.17 ± 0.27 8.24 ± 0.26 0.864 0.014 
  TT 7.58 ± 0.88 7.89 ± 0.81 9.33 ± 0.91 0.333  
    HOMA-IR  AA + AT 2.21 ± 0.08 2.08 ± 0.08 2.17 ± 0.08 0.726 0.012 
  TT 1.93 ± 0.25 2.16 ± 0.23 2.41 ± 0.26 0.287  
SFA (tertiles of intake, %)   3.1–9.4 9.4–11.8 11.8–19.0   
    Fasting glucose (mmol/l) 11482G→A GG + GA 5.62 ± 0.07 5.6 ± 0.07 5.66 ± 0.06 0.818 0.004 
      AA 5.35 ± 0.12 5.55 ± 0.12 5.82 ± 0.12 0.014  
    Fasting insulin (mU/l)  GG + GA 8.49 ± 0.31 8.37 ± 0.33 8.24 ± 0.28 0.938 0.004 
  AA 7.50 ± 0.60 7.52 ± 0.61 9.82 ± 0.60 0.030  
    HOMA-IR  GG + GA 2.19 ± 0.09 2.16 ± 0.10 2.17 ± 0.08 0.978 0.003 
  AA 1.79 ± 0.17 1.90 ± 0.17 2.65 ± 0.17 0.006  
    Fasting glucose (mmol/l) 14995A→T AA + AT 5.63 ± 0.07 5.57 ± 0.07 5.64 ± 0.06 0.816 0.009 
  TT 5.38 ± 0.14 5.69 ± 0.15 5.91 ± 0.14 0.006  
    Fasting insulin (mU/l)  AA + AT 8.29 ± 0.25 8.18 ± 0.24 7.89 ± 0.30 0.963 0.014 
  TT 7.59 ± 0.85 7.70 ± 0.90 9.20 ± 0.87 0.332  
    HOMA-IR  AA + AT 2.16 ± 0.08 2.15 ± 0.09 2.15 ± 0.07 0.983 0.005 
  TT 1.86 ± 0.24 2.00 ± 0.26 2.57 ± 0.25 0.095  
CHO (tertiles of intake, %)   34.5–56.3 56.3–61.7 61.7–84.5   
    Fasting glucose (mmol/l) 11482G→A GG + GA 5.52 ± 0.07 5.59 ± 0.07 5.72 ± 0.06 0.050 0.145 
      AA 5.72 ± 0.13 5.65 ± 0.12 5.39 ± 0.12 0.121  
    Fasting insulin (mU/l)  GG + GA 8.07 ± 0.30 8.43 ± 0.30 8.55 ± 0.30 0.244 0.007 
  AA 9.10 ± 0.61 8.54 ± 0.57 7.32 ± 0.64 0.042  
    HOMA-IR  GG + GA 2.12 ± 0.08 2.06 ± 0.09 2.18 ± 0.09 0.338 0.004 
  AA 2.35 ± 0.17 2.16 ± 0.16 1.89 ± 0.18 0.046  
    Fasting glucose (mmol/l) 14995A→T AA + AT 5.63 ± 0.07 5.50 ± 0.07 5.68 ± 0.07 0.726 0.293 
  TT 5.74 ± 0.12 5.53 ± 0.13 5.42 ± 0.12 0.213  
    Fasting insulin (mU/l)  AA + AT 7.97 ± 0.26 8.52 ± 0.27 8.50 ± 0.27 0.162 0.008 
  TT 9.22 ± 0.96 8.28 ± 0.78 7.32 ± 0.89 0.127  
    HOMA-IR  AA + AT 2.10 ± 0.08 2.15 ± 0.08 2.21 ± 0.08 0.282 0.012 
  TT 2.39 ± 0.28 2.20 ± 0.22 1.92 ± 0.26 0.143  
PolymorphismGenotypes*Tertiles
P trendP interaction
1 (n = 384)2 (n = 385)3 (n = 384)
Total fat (tertiles of intake, %)   7.1–25.2 25.2–29.8 29.8–54.1   
    Fasting glucose (mmol/l) 11482G→A GG + GA 5.62 ± 0.08 5.60 ± 0.07 5.68 ± 0.07 0.713 0.425 
  AA 5.41 ± 0.15 5.56 ± 0.14 5.62 ± 0.13 0.327  
    Fasting insulin (mU/l)  GG + GA 8.62 ± 0.31 8.16 ± 0.29 8.31 ± 0.30 0.824 0.010 
  AA 7.53 ± 0.62 8.10 ± 0.62 9.31 ± 0.59 0.134  
    HOMA-IR  GG + GA 2.23 ± 0.09 2.10 ± 0.08 2.19 ± 0.08 0.737 0.007 
  AA 1.89 ± 0.18 2.10 ± 0.17 2.41 ± 0.17 0.104  
    Fasting glucose (mmol/l) 14995A→T AA + AT 5.58 ± 0.07 5.56 ± 0.07 5.69 ± 0.07 0.338 0.448 
  TT 5.55 ± 0.14 5.58 ± 0.14 5.63 ± 0.12 0.574  
    Fasting insulin (mU/l)  AA + AT 8.58 ± 0.28 8.17 ± 0.27 8.24 ± 0.26 0.864 0.014 
  TT 7.58 ± 0.88 7.89 ± 0.81 9.33 ± 0.91 0.333  
    HOMA-IR  AA + AT 2.21 ± 0.08 2.08 ± 0.08 2.17 ± 0.08 0.726 0.012 
  TT 1.93 ± 0.25 2.16 ± 0.23 2.41 ± 0.26 0.287  
SFA (tertiles of intake, %)   3.1–9.4 9.4–11.8 11.8–19.0   
    Fasting glucose (mmol/l) 11482G→A GG + GA 5.62 ± 0.07 5.6 ± 0.07 5.66 ± 0.06 0.818 0.004 
      AA 5.35 ± 0.12 5.55 ± 0.12 5.82 ± 0.12 0.014  
    Fasting insulin (mU/l)  GG + GA 8.49 ± 0.31 8.37 ± 0.33 8.24 ± 0.28 0.938 0.004 
  AA 7.50 ± 0.60 7.52 ± 0.61 9.82 ± 0.60 0.030  
    HOMA-IR  GG + GA 2.19 ± 0.09 2.16 ± 0.10 2.17 ± 0.08 0.978 0.003 
  AA 1.79 ± 0.17 1.90 ± 0.17 2.65 ± 0.17 0.006  
    Fasting glucose (mmol/l) 14995A→T AA + AT 5.63 ± 0.07 5.57 ± 0.07 5.64 ± 0.06 0.816 0.009 
  TT 5.38 ± 0.14 5.69 ± 0.15 5.91 ± 0.14 0.006  
    Fasting insulin (mU/l)  AA + AT 8.29 ± 0.25 8.18 ± 0.24 7.89 ± 0.30 0.963 0.014 
  TT 7.59 ± 0.85 7.70 ± 0.90 9.20 ± 0.87 0.332  
    HOMA-IR  AA + AT 2.16 ± 0.08 2.15 ± 0.09 2.15 ± 0.07 0.983 0.005 
  TT 1.86 ± 0.24 2.00 ± 0.26 2.57 ± 0.25 0.095  
CHO (tertiles of intake, %)   34.5–56.3 56.3–61.7 61.7–84.5   
    Fasting glucose (mmol/l) 11482G→A GG + GA 5.52 ± 0.07 5.59 ± 0.07 5.72 ± 0.06 0.050 0.145 
      AA 5.72 ± 0.13 5.65 ± 0.12 5.39 ± 0.12 0.121  
    Fasting insulin (mU/l)  GG + GA 8.07 ± 0.30 8.43 ± 0.30 8.55 ± 0.30 0.244 0.007 
  AA 9.10 ± 0.61 8.54 ± 0.57 7.32 ± 0.64 0.042  
    HOMA-IR  GG + GA 2.12 ± 0.08 2.06 ± 0.09 2.18 ± 0.09 0.338 0.004 
  AA 2.35 ± 0.17 2.16 ± 0.16 1.89 ± 0.18 0.046  
    Fasting glucose (mmol/l) 14995A→T AA + AT 5.63 ± 0.07 5.50 ± 0.07 5.68 ± 0.07 0.726 0.293 
  TT 5.74 ± 0.12 5.53 ± 0.13 5.42 ± 0.12 0.213  
    Fasting insulin (mU/l)  AA + AT 7.97 ± 0.26 8.52 ± 0.27 8.50 ± 0.27 0.162 0.008 
  TT 9.22 ± 0.96 8.28 ± 0.78 7.32 ± 0.89 0.127  
    HOMA-IR  AA + AT 2.10 ± 0.08 2.15 ± 0.08 2.21 ± 0.08 0.282 0.012 
  TT 2.39 ± 0.28 2.20 ± 0.22 1.92 ± 0.26 0.143  

Data are means ± SE.

*

The distribution of PLIN genotypes in these 1,153 women were 424 GG, 552 GA, and 177 AA for the 11482G→A and 378 AA, 567 AT, and 208 TT for the 14995A→T.

P for lineal trend was estimated by comparing adjusted means of insulin resistance variables across tertiles of macronutrient intake depending on the genotype group (expressed as percent of energy). Means were adjusted for ethnicity, age, BMI, cigarette smoking, alcohol consumption, physical activity, diabetes status, and energy intake. Further adjustment of means for fat or carbohydrate did not modify the statistical significance of results.

P value for the interaction term between the PLIN polymorphisms and tertiles of the corresponding macronutrient in the hierarchial multivariate regression model. CHO, carbohydrate.

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