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Table 2—

Odds ratios and 95% CIs from logistic regression models predicting nonadherence to metformin by reported barriers and predicting adherence to metformin by reported strategies

Odds ratio (95% CI)*P value*
Reported barriers   
    No barriers 1.00 — 
    Disruption of routines 3.62 (2.82–4.64) <0.0001 
    Forgets 5.11 (4.30–6.07) <0.0001 
    Adverse effects 9.69 (7.86–11.95) <0.0001 
    Forgets and disruption of routines 8.76 (6.30–12.18) <0.0001 
    Adverse effects and disruption of routines 9.66 (5.42–17.24) <0.0001 
    Forgets, adverse effects, and disruption of routines 19.21 (5.07–72.79) <0.0001 
Reported strategies   
    No strategies 1.00 — 
    Time routine 1.15 (0.90–1.46) 0.25 
    Activity strategy 1.36 (1.06–1.76) 0.02 
    Reminder device 1.57 (1.19–2.07) 0.0015 
    Both time and activity 1.66 (1.29–2.15) 0.0001 
    Both time and reminder device 1.68 (1.25–2.27) 0.0006 
    Both activity and reminder device 1.74 (1.24–2.42) 0.0012 
    Time, activity, and reminder device 2.69 (1.67–4.33) <0.0001 
Odds ratio (95% CI)*P value*
Reported barriers   
    No barriers 1.00 — 
    Disruption of routines 3.62 (2.82–4.64) <0.0001 
    Forgets 5.11 (4.30–6.07) <0.0001 
    Adverse effects 9.69 (7.86–11.95) <0.0001 
    Forgets and disruption of routines 8.76 (6.30–12.18) <0.0001 
    Adverse effects and disruption of routines 9.66 (5.42–17.24) <0.0001 
    Forgets, adverse effects, and disruption of routines 19.21 (5.07–72.79) <0.0001 
Reported strategies   
    No strategies 1.00 — 
    Time routine 1.15 (0.90–1.46) 0.25 
    Activity strategy 1.36 (1.06–1.76) 0.02 
    Reminder device 1.57 (1.19–2.07) 0.0015 
    Both time and activity 1.66 (1.29–2.15) 0.0001 
    Both time and reminder device 1.68 (1.25–2.27) 0.0006 
    Both activity and reminder device 1.74 (1.24–2.42) 0.0012 
    Time, activity, and reminder device 2.69 (1.67–4.33) <0.0001 
*

Barriers and strategies were modeled separately. P values are based on repeated-measures modeling using generalized estimating equations.

There were very few participants in this category, 11 throughout the study and only 1 or 2 at each quarterly visit.

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