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Table 3—

Adjusted HRs for all-cause mortality and cardiovascular, renal, and composite end point outcomes among 4,421 Chinese type 2 diabetic patients without macrovascular disease and end-stage renal disease at baseline

eGFR (ml/min per 1.73 m2)
P
≥90*60–8930–5915–29
Median eGFR (ml/min per 1.73 m2107 78 50 24  
Cardiovascular end points      
    Age and sex adjusted 1.00 1.18 (0.83–1.68) 1.66 (1.09–2.54) 5.15 (2.94–9.00) <0.001 
    Multivariate-adjusted model 1 1.00 1.04 (0.72–1.48) 1.12 (0.71–1.76) 3.82 (2.13–6.86) <0.001 
    Multivariate-adjusted model 2 1.00 1.04 (0.73–1.50) 1.05 (0.66–1.68) 3.23 (1.74–5.99) <0.001 
All-cause mortality      
    Age and sex adjusted 1.00 1.20 (0.72–1.99) 1.83 (1.01–3.31) 8.34 (4.13–16.8) <0.001 
    Multivariate-adjusted model 1 1.00 1.25 (0.73–2.14) 2.25 (1.12–4.52) 9.7 (4.47–21.1) <0.001 
    Multivariate-adjusted model 2 1.00 1.27 (0.74–2.17) 2.34 (1.16–4.70) 9.82 (4.53–21.0) <0.001 
Renal end points      
    Age and sex adjusted 1.00 1.91 (1.23–2.98) 11.4 (7.58–17.1) 120.9 (75.8–192.7 ) <0.001 
    Multivariate-adjusted model 1 1.00 1.45 (0.92–2.28) 4.90 (3.08–7.80) 45.9 (26.5–79.6) <0.001 
    Multivariate-adjusted model 2 1.00 1.36 (0.83–2.16) 3.34 (2.06–5.42) 27.3 (15.6–47.8) <0.001 
Composite end points      
    Crude 1.00 1.28 (0.98–1.69) 2.93 (2.14–3.99) 15.2 (10.5–22.2) <0.001 
    Multivariate-adjusted model 1 1.00 1.13 (0.85–1.50) 1.85 (1.32–2.60) 9.98 (6.68–14.9) <0.001 
    Multivariate-adjusted model 2 1.00 1.13 (0.85–1.49) 1.63 (1.15–2.30) 7.54 (4.97–11.4) <0.001 
eGFR (ml/min per 1.73 m2)
P
≥90*60–8930–5915–29
Median eGFR (ml/min per 1.73 m2107 78 50 24  
Cardiovascular end points      
    Age and sex adjusted 1.00 1.18 (0.83–1.68) 1.66 (1.09–2.54) 5.15 (2.94–9.00) <0.001 
    Multivariate-adjusted model 1 1.00 1.04 (0.72–1.48) 1.12 (0.71–1.76) 3.82 (2.13–6.86) <0.001 
    Multivariate-adjusted model 2 1.00 1.04 (0.73–1.50) 1.05 (0.66–1.68) 3.23 (1.74–5.99) <0.001 
All-cause mortality      
    Age and sex adjusted 1.00 1.20 (0.72–1.99) 1.83 (1.01–3.31) 8.34 (4.13–16.8) <0.001 
    Multivariate-adjusted model 1 1.00 1.25 (0.73–2.14) 2.25 (1.12–4.52) 9.7 (4.47–21.1) <0.001 
    Multivariate-adjusted model 2 1.00 1.27 (0.74–2.17) 2.34 (1.16–4.70) 9.82 (4.53–21.0) <0.001 
Renal end points      
    Age and sex adjusted 1.00 1.91 (1.23–2.98) 11.4 (7.58–17.1) 120.9 (75.8–192.7 ) <0.001 
    Multivariate-adjusted model 1 1.00 1.45 (0.92–2.28) 4.90 (3.08–7.80) 45.9 (26.5–79.6) <0.001 
    Multivariate-adjusted model 2 1.00 1.36 (0.83–2.16) 3.34 (2.06–5.42) 27.3 (15.6–47.8) <0.001 
Composite end points      
    Crude 1.00 1.28 (0.98–1.69) 2.93 (2.14–3.99) 15.2 (10.5–22.2) <0.001 
    Multivariate-adjusted model 1 1.00 1.13 (0.85–1.50) 1.85 (1.32–2.60) 9.98 (6.68–14.9) <0.001 
    Multivariate-adjusted model 2 1.00 1.13 (0.85–1.49) 1.63 (1.15–2.30) 7.54 (4.97–11.4) <0.001 

Model 1 adjusted for age, sex, duration of diabetes, smoking habit, BMI, systolic blood pressure, A1C, HDL and LDL cholesterol, triglycerides, diabetic retinopathy at baseline, and treatment with ACE inhibitors or angiotensin receptor blockers. Model 2 adjusted for albuminuria in addition to covariates as in model 1.

*

This group served as the reference group.

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