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Table 1—

Baseline characteristics and metabolic parameters of IGTN study participants

Baseline1 yearSignificance
Age (years) 60 ± 8.4   
Duration of neuropathy symptoms (months) 7 ± 31   
Exercise (min/week) 80 ± 73   
Sex    
    Female 20   
    Male 20   
Metabolic features    
    BMI (kg/m232.1 ± 4.4 31.0 ± 4.4 P < 0.001 
    Fasting plasma glucose (mg/dl) 103 ± 13 104 ± 12 P < 0.7 
    2-h glucose (mg/dl) 160 ± 26 149 ± 41 P < 0.05 
    Cholesterol    
        Total 200 ± 31 190 ± 33 P < 0.01 
        LDL 113 ± 27 97.9 ± 40 P < 0.06 
        HDL 49.6 ± 13 54.1 ± 15 P < 0.06 
        Triglycerides 237 ± 174 196 ± 156 P < 0.7 
        Systolic blood pressure (mmHg) 129 ± 13 125 ± 14 P < 0.12 
        Diastolic blood pressure (mmHg) 80.7 ± 8.6 77.7 ± 6.2 P < 0.10 
n with other microvascular complications    
    Retinopathy   
    Microalbuminuria   
Baseline1 yearSignificance
Age (years) 60 ± 8.4   
Duration of neuropathy symptoms (months) 7 ± 31   
Exercise (min/week) 80 ± 73   
Sex    
    Female 20   
    Male 20   
Metabolic features    
    BMI (kg/m232.1 ± 4.4 31.0 ± 4.4 P < 0.001 
    Fasting plasma glucose (mg/dl) 103 ± 13 104 ± 12 P < 0.7 
    2-h glucose (mg/dl) 160 ± 26 149 ± 41 P < 0.05 
    Cholesterol    
        Total 200 ± 31 190 ± 33 P < 0.01 
        LDL 113 ± 27 97.9 ± 40 P < 0.06 
        HDL 49.6 ± 13 54.1 ± 15 P < 0.06 
        Triglycerides 237 ± 174 196 ± 156 P < 0.7 
        Systolic blood pressure (mmHg) 129 ± 13 125 ± 14 P < 0.12 
        Diastolic blood pressure (mmHg) 80.7 ± 8.6 77.7 ± 6.2 P < 0.10 
n with other microvascular complications    
    Retinopathy   
    Microalbuminuria   

Data are means ± SD. Five subjects with IGT were included on the basis of isolated IFG (mean fasting plasma glucose 117 [range 112–125]). At 1 year, three of these five had IGT. Over the 1st year there was significant improvement in BMI, OGTT, and total cholesterol, with a trend toward improvement of LDL and HDL cholesterol. Retinal photography and assessment for microalbuminuria occurred at baseline only.

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