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Table 2—

Glucose and insulin variables derived from the intravenous glucose tolerance test, according to timing of prenatal exposure to the Dutch famine

Born before famineExposed to famine in late gestationExposed to famine in mid-gestationExposed to famine in early gestationConceived after famineAlln
Basal glucose (mmol/l) 5.1 4.8 5.0 5.0 5.0 5.0 ± 1.1 93 
Basal insulin (pmol/l) 55 60 56 71 63 61 ± 1.6 93 
Glucose tolerance index (Kg) (10−2 · min−11.96 1.82 1.55* 1.41* 1.87 1.72 ± 1.4 90 
First-phase insulin response (AIRG) (min · pmol · l−12,343 2,354 2,095 2,118 2,648 2,311 ± 1.8 88 
Second-phase insulin response (min · pmol · l−120,308 21,299 26,515 24,680 24,212 23,211 ± 1.9 85 
Si (10−4 · min−1 per pmol/l) 0.67 0.64 0.54 0.59 0.61 0.61 ± 1.8 94 
Sg (10−2 · min−11.81 1.91 1.69 1.65 2.00 1.81 ± 1.5 94 
Disposition index (Si × AIRG1,576 1,539 1,059* 1,252 1,576 1,392 ± 2 88 
Born before famineExposed to famine in late gestationExposed to famine in mid-gestationExposed to famine in early gestationConceived after famineAlln
Basal glucose (mmol/l) 5.1 4.8 5.0 5.0 5.0 5.0 ± 1.1 93 
Basal insulin (pmol/l) 55 60 56 71 63 61 ± 1.6 93 
Glucose tolerance index (Kg) (10−2 · min−11.96 1.82 1.55* 1.41* 1.87 1.72 ± 1.4 90 
First-phase insulin response (AIRG) (min · pmol · l−12,343 2,354 2,095 2,118 2,648 2,311 ± 1.8 88 
Second-phase insulin response (min · pmol · l−120,308 21,299 26,515 24,680 24,212 23,211 ± 1.9 85 
Si (10−4 · min−1 per pmol/l) 0.67 0.64 0.54 0.59 0.61 0.61 ± 1.8 94 
Sg (10−2 · min−11.81 1.91 1.69 1.65 2.00 1.81 ± 1.5 94 
Disposition index (Si × AIRG1,576 1,539 1,059* 1,252 1,576 1,392 ± 2 88 

Data are geometric means ± SD unless otherwise indicated.

*

Statistically significant difference (P < 0.05, adjusted for sex and BMI) compared with people unexposed to famine in utero.

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