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Table 3—

Risk of type 2 diabetes by combinations of total coffee consumption and caffeine intake

Quintiles of caffeine intake
Q1–Q2Q3Q4–Q5
Total coffee less than one cup per day    
    Median coffee consumption (cups/day) 
    Median caffeine intake (mg/day) 52 173 287 
    Number of cases/person-years 533/292,658 184/79,183 42/18,638 
    RR (95% CI) 1 (ref.) 1.02 (0.86–1.21) 0.85 (0.62–1.16) 
Total coffee 1.0–1.9 cups/day    
    Median coffee consumption (cups/day) 1.1 1.1 1.6 
    Median caffeine intake (mg/day) 74 186 297 
    Number of cases/person-years 38/31,550 87/68,142 74/40,348 
    RR (95% CI) 0.89 (0.63–1.23) 0.88 (0.70–1.10) 0.90 (0.70–1.16) 
Total coffee two or more cups per day    
    Median coffee consumption (cups/day) 2.5 2.5 2.6 
    Median caffeine intake (mg/day) 51 189 430 
    Number of cases/person-years 18/22,979 20/25,533 267/287,087 
    RR (95% CI) 0.52 (0.32–0.83) 0.50 (0.32–0.79) 0.59 (0.50–0.69) 
Quintiles of caffeine intake
Q1–Q2Q3Q4–Q5
Total coffee less than one cup per day    
    Median coffee consumption (cups/day) 
    Median caffeine intake (mg/day) 52 173 287 
    Number of cases/person-years 533/292,658 184/79,183 42/18,638 
    RR (95% CI) 1 (ref.) 1.02 (0.86–1.21) 0.85 (0.62–1.16) 
Total coffee 1.0–1.9 cups/day    
    Median coffee consumption (cups/day) 1.1 1.1 1.6 
    Median caffeine intake (mg/day) 74 186 297 
    Number of cases/person-years 38/31,550 87/68,142 74/40,348 
    RR (95% CI) 0.89 (0.63–1.23) 0.88 (0.70–1.10) 0.90 (0.70–1.16) 
Total coffee two or more cups per day    
    Median coffee consumption (cups/day) 2.5 2.5 2.6 
    Median caffeine intake (mg/day) 51 189 430 
    Number of cases/person-years 18/22,979 20/25,533 267/287,087 
    RR (95% CI) 0.52 (0.32–0.83) 0.50 (0.32–0.79) 0.59 (0.50–0.69) 

RRs were multivariate adjusted as described in the legend of Table 2.

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