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Table 1—

The association of baseline clinical data and lipid variables with progression in patients with normoalbuminuria

NonprogressorsProgressors
n 47 14 
Baseline AER (geometric mean) (μg/min) 5.1 9.5 
End point AER (geometric mean) (μg/min) 7.1 63 
Baseline CrCl (ml/min per 1.73 m299 ± 2 105 ± 6 
End point CrCl (ml/min per 1.73 m2100 ± 3 96 ± 4 
Sex (% male) 78 40* 
HbA1c (%) 7.8 ± 0.2 8.1 ± 0.3 
Blood pressure (mmHg) 121/78 ± 2/1 120/76 ± 3/2 
LDL cholesterol (mmol/l) 2.6 ± 0.1 3.4 ± 0.3* 
Non-HDL cholesterol (mmol/l) 3.0 ± 0.1 3.8 ± 0.2* 
Triglycerides (mmol/l) 0.97 ± 0.09 0.96 ± 0.07 
HDL cholesterol (mmol/l) 1.6 ± 0.1 1.5 ± 0.1 
LDL free cholesterol (mmol/l) 0.74 ± 0.02 0.92 ± 0.07* 
LDL mass (mg/dl) 296 ± 9 373 ± 23* 
ApoAI (mg/dl) 155 ± 3 138 ± 5* 
LDL size (nm) 25.7 ± 0.1 25.9 ± 0.2 
LPL15 (μmol FFA · ml−1 · h−139 ± 1 37 ± 3 
HL15 (μmol FFA · ml−1 · h−125 ± 1 30 ± 4 
NonprogressorsProgressors
n 47 14 
Baseline AER (geometric mean) (μg/min) 5.1 9.5 
End point AER (geometric mean) (μg/min) 7.1 63 
Baseline CrCl (ml/min per 1.73 m299 ± 2 105 ± 6 
End point CrCl (ml/min per 1.73 m2100 ± 3 96 ± 4 
Sex (% male) 78 40* 
HbA1c (%) 7.8 ± 0.2 8.1 ± 0.3 
Blood pressure (mmHg) 121/78 ± 2/1 120/76 ± 3/2 
LDL cholesterol (mmol/l) 2.6 ± 0.1 3.4 ± 0.3* 
Non-HDL cholesterol (mmol/l) 3.0 ± 0.1 3.8 ± 0.2* 
Triglycerides (mmol/l) 0.97 ± 0.09 0.96 ± 0.07 
HDL cholesterol (mmol/l) 1.6 ± 0.1 1.5 ± 0.1 
LDL free cholesterol (mmol/l) 0.74 ± 0.02 0.92 ± 0.07* 
LDL mass (mg/dl) 296 ± 9 373 ± 23* 
ApoAI (mg/dl) 155 ± 3 138 ± 5* 
LDL size (nm) 25.7 ± 0.1 25.9 ± 0.2 
LPL15 (μmol FFA · ml−1 · h−139 ± 1 37 ± 3 
HL15 (μmol FFA · ml−1 · h−125 ± 1 30 ± 4 

Data are means ± SE unless otherwise indicated.

*

Progressors vs. nonprogressors, univariate P < 0.05.

Progressors vs. nonprogressors, adjusted P < 0.05. CrCl, creatinine clearance; FFA, free fatty acid; HL15, hepatic lipase 15 min after an intravenous bolus of heparin; LPL15, lipoprotein lipase 15 min after an intravenous bolus of heparin.

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