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Table 2—

Unadjusted and adjusted HR of developing diabetes associated with uninterrupted use of each initial method of contraception and with 1) baseline triglycerides below or above the cohort median of 150 mg/dl and 2) with or without breast-feeding*

Unadjusted
Adjusted
HR (95% CI)P valueHR (95% CI)P value
Triglyceride interaction 1.00 — 1.00 — 
    COCs and below median (n = 206, mean TG = 108 mg/dl)     
    DMPA and below median (n = 57, mean TG = 97 mg/dl) 1.02 (0.47–2.22) 0.95 0.55 (0.22–1.31) 0.20 
    COCs and above median (n = 224, mean TG = 248 mg/dl) 1.53 (1.00–2.37) 0.059 1.39 (0.88–2.19) 0.16 
    DMPA and above median (n = 39, mean TG = 245 mg/dl) 3.85 (2.04–7.24) <0.0001 2.28 (1.08–4.81) 0.03 
Breast-feeding interaction     
    COCs without breast-feeding (n = 430) 1.00 — 1.00 — 
    DMPA without breast-feeding (n = 74) 1.28 (0.72–2.27) 0.40 1.06 (0.58–1.95) 0.85 
    DMPA with breast-feeding (n = 22) 3.45 (1.57–7.57) 0.002 2.21 (0.96–5.11) 0.06 
Unadjusted
Adjusted
HR (95% CI)P valueHR (95% CI)P value
Triglyceride interaction 1.00 — 1.00 — 
    COCs and below median (n = 206, mean TG = 108 mg/dl)     
    DMPA and below median (n = 57, mean TG = 97 mg/dl) 1.02 (0.47–2.22) 0.95 0.55 (0.22–1.31) 0.20 
    COCs and above median (n = 224, mean TG = 248 mg/dl) 1.53 (1.00–2.37) 0.059 1.39 (0.88–2.19) 0.16 
    DMPA and above median (n = 39, mean TG = 245 mg/dl) 3.85 (2.04–7.24) <0.0001 2.28 (1.08–4.81) 0.03 
Breast-feeding interaction     
    COCs without breast-feeding (n = 430) 1.00 — 1.00 — 
    DMPA without breast-feeding (n = 74) 1.28 (0.72–2.27) 0.40 1.06 (0.58–1.95) 0.85 
    DMPA with breast-feeding (n = 22) 3.45 (1.57–7.57) 0.002 2.21 (0.96–5.11) 0.06 
*

For the 11 women who switched methods, data were used up to the time when switch occurred.

Adjusted for baseline unbalances of BMI, diabetes in family, breast-feeding status (in analyses for triglyceride [TG] interactions), triglycerides (in analyses for breast-feeding interactions), HDL cholesterol and weight change during follow-up.

By Cox regression analysis. ‡Reference group for HR calculation.

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