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Table 2—

Mean changes in metabolic and pain parameters in pooled DPNP studies

Acute studies
Extension studies
DuloxetinePlaceboPDuloxetineRoutine careP
n 685 339  580 287  
FPG (mmol/l) 0.50 −0.11 0.064 0.67 −0.64 <0.001 
A1C (%) −0.09 −0.07 0.766 0.52 0.19 <0.001 
Triglycerides (mmol/l) −0.19 0.07 0.106 0.05 0.00 0.854 
LDL cholesterol (mmol/l) 0.08 −0.02 0.075 0.02 −0.09 0.068 
HDL cholesterol (mmol/l) 0.03 0.00 0.008 −0.01 −0.08 0.002 
Total cholesterol (mmol/l) 0.07 −0.03 0.090 0.06 −0.16 0.005 
Weight (kg) −1.03 0.03 <0.001 0.31 0.49 0.531 
Pain severity (0–10 scale) −2.70 −1.64 <0.001 NA NA  
Acute studies
Extension studies
DuloxetinePlaceboPDuloxetineRoutine careP
n 685 339  580 287  
FPG (mmol/l) 0.50 −0.11 0.064 0.67 −0.64 <0.001 
A1C (%) −0.09 −0.07 0.766 0.52 0.19 <0.001 
Triglycerides (mmol/l) −0.19 0.07 0.106 0.05 0.00 0.854 
LDL cholesterol (mmol/l) 0.08 −0.02 0.075 0.02 −0.09 0.068 
HDL cholesterol (mmol/l) 0.03 0.00 0.008 −0.01 −0.08 0.002 
Total cholesterol (mmol/l) 0.07 −0.03 0.090 0.06 −0.16 0.005 
Weight (kg) −1.03 0.03 <0.001 0.31 0.49 0.531 
Pain severity (0–10 scale) −2.70 −1.64 <0.001 NA NA  
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