Baseline BMI, waist circumference, and RR of type 2 diabetes in the Nurses’ Health Study from 1986 through 2002
| . | BMI (kg/m2) (n = 68,907) . | . | . | . | . | . | . | . | . | . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | <21 . | 21–22.9 . | 23–24.9 . | 25–26.9 . | 27–29.9 . | 30–32.9 . | 33–34.9 . | 35–39.9 . | 40 . | P for trend . | |||||||||
| n | 95 | 224 | 438 | 555 | 944 | 730 | 328 | 482 | 234 | ||||||||||
| Person-years (1,034,808 ) | 165,274 | 229,913 | 224,553 | 150,502 | 137,714 | 67,443 | 22,615 | 26,277 | 10,567 | ||||||||||
| Age-adjusted RR (95% CI) | 1.00 | 1.68 (1.32–2.13) | 3.32 (2.66–4.14) | 6.26 (5.04–7.79) | 11.67 (9.45–14.41) | 18.62 (15.04–23.07) | 25.31 (20.14–31.81) | 32.56 (26.12–40.57) | 40.28 (31.73–51.13) | <0.001 | |||||||||
| Multivariate RR (95% CI)* | 1.00 | 1.65 (1.30–2.10) | 3.10 (2.48–3.87) | 5.51 (4.43–6.86) | 9.80 (7.93–12.11) | 14.83 (11.96–18.39) | 19.11 (15.19–24.06) | 23.98 (19.21–29.95) | 27.96 (21.97–35.58) | <0.001 | |||||||||
| . | BMI (kg/m2) (n = 68,907) . | . | . | . | . | . | . | . | . | . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | <21 . | 21–22.9 . | 23–24.9 . | 25–26.9 . | 27–29.9 . | 30–32.9 . | 33–34.9 . | 35–39.9 . | 40 . | P for trend . | |||||||||
| n | 95 | 224 | 438 | 555 | 944 | 730 | 328 | 482 | 234 | ||||||||||
| Person-years (1,034,808 ) | 165,274 | 229,913 | 224,553 | 150,502 | 137,714 | 67,443 | 22,615 | 26,277 | 10,567 | ||||||||||
| Age-adjusted RR (95% CI) | 1.00 | 1.68 (1.32–2.13) | 3.32 (2.66–4.14) | 6.26 (5.04–7.79) | 11.67 (9.45–14.41) | 18.62 (15.04–23.07) | 25.31 (20.14–31.81) | 32.56 (26.12–40.57) | 40.28 (31.73–51.13) | <0.001 | |||||||||
| Multivariate RR (95% CI)* | 1.00 | 1.65 (1.30–2.10) | 3.10 (2.48–3.87) | 5.51 (4.43–6.86) | 9.80 (7.93–12.11) | 14.83 (11.96–18.39) | 19.11 (15.19–24.06) | 23.98 (19.21–29.95) | 27.96 (21.97–35.58) | <0.001 | |||||||||
| . | Waist circumference (inches) (n = 43,986) . | . | . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| . | 20–28 . | 28–29.9 . | 30–31.9 . | 32–34.9 . | ≥35 . | P for trend . | |||||
| n | 58 | 156 | 248 | 584 | 1,096 | ||||||
| Person-years (664,976 ) | 149,922 | 156,197 | 125,540 | 131,638 | 101,633 | ||||||
| Age-adjusted RR (95% CI) | 1.00 | 2.55 (1.89–3.45) | 5.03 (3.78–6.69) | 11.25 (8.58–14.75) | 27.69 (21.24–36.09) | <0.001 | |||||
| Multivariate RR (95% CI)* | 1.00 | 2.48 (1.83–3.35) | 4.62 (3.47–6.15) | 9.51 (7.25–12.47) | 21.44 (16.42–28.00) | <0.001 | |||||
| . | Waist circumference (inches) (n = 43,986) . | . | . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| . | 20–28 . | 28–29.9 . | 30–31.9 . | 32–34.9 . | ≥35 . | P for trend . | |||||
| n | 58 | 156 | 248 | 584 | 1,096 | ||||||
| Person-years (664,976 ) | 149,922 | 156,197 | 125,540 | 131,638 | 101,633 | ||||||
| Age-adjusted RR (95% CI) | 1.00 | 2.55 (1.89–3.45) | 5.03 (3.78–6.69) | 11.25 (8.58–14.75) | 27.69 (21.24–36.09) | <0.001 | |||||
| Multivariate RR (95% CI)* | 1.00 | 2.48 (1.83–3.35) | 4.62 (3.47–6.15) | 9.51 (7.25–12.47) | 21.44 (16.42–28.00) | <0.001 | |||||
Adjusted for age (<49, 50–54, 55–59, 60–64, and 65 years), smoking status (never, past, or current [1–14, 15–24, or 25 cigarettes/day]), family history of diabetes, postmenopausal status and hormone use (pre- and postmenopausal status and hormone use as never, past, or current), physical activity (quintiles), and alcohol consumption (0, 0.1–4.9, 5–14.9, or 15 g/day).