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Table 1—

Efficacy parameters in patients receiving vildagliptin (100 mg daily)

All
Aged <65 years
Aged ≥65 years
BLAMΔBLAMΔBLAMΔ
n 1,469  1,231  238  
A1C (%) 8.6 ± 0.0 −1.0 ± 0.0* 8.7 ± 0.0 −1.0 ± 0.0* 8.3 ± 0.1 −1.2 ± 0.1* 
FPG (mmol/l) 10.4 ± 0.1 −1.1 ± 0.1* 10.5 ± 0.1 −1.1 ± 0.1* 9.6 ± 0.1 −1.5 ± 0.2* 
Body weight (kg) 90.6 ± 0.5 −0.3 ± 0.1 92.0 ± 0.6 −0.2 ± 0.1 83.4 ± 1.0 −0.9 ± 0.3* 
Responder analyses (achieving A1C <7.0%) n n (%) responders n n (%) responders n n (%) responders 
Overall 1,462 548 (37.5) 1,226 438 (35.7) 236 110 (44.6) 
Baseline A1C ≤8.0% 526 286 (54.4) 405 210 (51.9) 121 76 (62.8) 
Fasting lipids (mmol/l)  AM%Δ  AM%Δ  AM%Δ 
    Triglycerides 2.4 ± 0.1 −3.3 ± 1.3* 2.4 ± 0.1 −2.8 ± 1.4* 2.1 ± 0.1 −6.3 ± 2.9* 
    Total cholesterol 5.3 ± 0.0 −2.2 ± 0.4* 5.3 ± 0.0 −2.0 ± 0.5* 5.3 ± 0.1 −3.0 ± 1.0* 
    LDL 3.1 ± 0.0 −0.7 ± 0.8 3.1 ± 0.0 −0.3 ± 0.8 3.1 ± 0.1 −2.5 ± 1.7 
    HDL 1.2 ± 0.0 4.5 ± 0.6* 1.1 ± 0.0 4.5 ± 0.6* 1.3 ± 0.0 4.8 ± 1.3* 
    Non-HDL 4.1 ± 0.0 −3.3 ± 0.6* 4.2 ± 0.0 −3.0 ± 0.6* 4.0 ± 0.1 −4.9 ± 1.3* 
    VLDL 0.95 ± 0.01 −3.4 ± 1.1* 1.0 ± 0.0 −3.0 ± 1.3* 0.9 ± 0.0 −5.3 ± 2.4* 
Blood pressure (mmHg)  mean Δ  mean Δ  mean Δ 
    Diastolic 81.3 ± 0.3 −1.4 ± 0.2* 81.5 ± 0.2 −1.3 ± 0.2* 80.1 ± 0.5 −2.0 ± 0.5* 
    Systolic 132.1 ± 0.3 −2.2 ± 0.3* 130.8 ± 0.4 −2.2 ± 0.4* 138.5 ± 0.8 −2.2 ± 1.0* 
Subgroup analyses BL (nAMΔ BL (nAMΔ BL (nAMΔ 
    A1C (%)       
BL A1C ≤8.0% 7.6 (533) −0.6 ± 0.0* 7.6 (410) −0.6 ± 0.1* 7.6 (123) −0.7 ± 0.1* 
BL A1C >8.0% 9.2 (936) −1.3 ± 0.1* 9.2 (821) −1.2 ± 0.1* 9.0 (115) −1.4 ± 0.1* 
BL A1C ≤9.0% 8.1 (995) −0.8 ± 0.0* 8.1 (806) −0.7 ± 0.0* 7.9 (189) −0.9 ± 0.1* 
BL A1C >9.0% 9.9 (474) −1.6 ± 0.1* 9.9 (425) −1.6 ± 0.1* 9.7 (49) −1.7 ± 0.2* 
BL BMI <30 kg/m2 8.7 (613) −1.2 ± 0.1* 8.8 (487) −1.2 ± 0.1* 8.4 (126) −1.3 ± 0.1* 
BL BMI ≥30 kg/m2 8.6 (855) −0.9 ± 0.1* 8.7 (743) −0.9 ± 0.1* 8.2 (112) −1.0 ± 0.1* 
BL BMI <35 kg/m2 8.7 (1,034) −1.1 ± 0.0* 8.8 (838) −1.1 ± 0.1* 8.3 (196) −1.2 ± 0.1* 
BL BMI ≥35 kg/m2 8.6 (434) −0.9 ± 0.1* 8.6 (392) −0.9 ± 0.1* 8.2 (42) −0.9 ± 0.2* 
    Body weight (kg)       
BL BMI <30 kg/m2 75.6 (613) −0.0 ± 0.1 75.8 (487) 0.1 ± 0.1 74.5 (126) −0.5 ± 0.3 
BL BMI ≥30 kg/m2 101.3 (855) −0.6 ± 0.2* 102.6 (743) −0.5 ± 0.2* 93.3 (112) −1.3 ± 0.4* 
BL BMI <35 kg/m2 82.1 (1,034) −0.2 ± 0.1 82.8 (838) −0.1 ± 0.1 79.4 (196) −0.8 ± 0.2* 
BL BMI ≥35 kg/m2 110.7 (434) −0.6 ± 0.3* 111.7 (392) −0.6 ± 0.3* 101.8 (42) −1.4 ± 0.7* 
All
Aged <65 years
Aged ≥65 years
BLAMΔBLAMΔBLAMΔ
n 1,469  1,231  238  
A1C (%) 8.6 ± 0.0 −1.0 ± 0.0* 8.7 ± 0.0 −1.0 ± 0.0* 8.3 ± 0.1 −1.2 ± 0.1* 
FPG (mmol/l) 10.4 ± 0.1 −1.1 ± 0.1* 10.5 ± 0.1 −1.1 ± 0.1* 9.6 ± 0.1 −1.5 ± 0.2* 
Body weight (kg) 90.6 ± 0.5 −0.3 ± 0.1 92.0 ± 0.6 −0.2 ± 0.1 83.4 ± 1.0 −0.9 ± 0.3* 
Responder analyses (achieving A1C <7.0%) n n (%) responders n n (%) responders n n (%) responders 
Overall 1,462 548 (37.5) 1,226 438 (35.7) 236 110 (44.6) 
Baseline A1C ≤8.0% 526 286 (54.4) 405 210 (51.9) 121 76 (62.8) 
Fasting lipids (mmol/l)  AM%Δ  AM%Δ  AM%Δ 
    Triglycerides 2.4 ± 0.1 −3.3 ± 1.3* 2.4 ± 0.1 −2.8 ± 1.4* 2.1 ± 0.1 −6.3 ± 2.9* 
    Total cholesterol 5.3 ± 0.0 −2.2 ± 0.4* 5.3 ± 0.0 −2.0 ± 0.5* 5.3 ± 0.1 −3.0 ± 1.0* 
    LDL 3.1 ± 0.0 −0.7 ± 0.8 3.1 ± 0.0 −0.3 ± 0.8 3.1 ± 0.1 −2.5 ± 1.7 
    HDL 1.2 ± 0.0 4.5 ± 0.6* 1.1 ± 0.0 4.5 ± 0.6* 1.3 ± 0.0 4.8 ± 1.3* 
    Non-HDL 4.1 ± 0.0 −3.3 ± 0.6* 4.2 ± 0.0 −3.0 ± 0.6* 4.0 ± 0.1 −4.9 ± 1.3* 
    VLDL 0.95 ± 0.01 −3.4 ± 1.1* 1.0 ± 0.0 −3.0 ± 1.3* 0.9 ± 0.0 −5.3 ± 2.4* 
Blood pressure (mmHg)  mean Δ  mean Δ  mean Δ 
    Diastolic 81.3 ± 0.3 −1.4 ± 0.2* 81.5 ± 0.2 −1.3 ± 0.2* 80.1 ± 0.5 −2.0 ± 0.5* 
    Systolic 132.1 ± 0.3 −2.2 ± 0.3* 130.8 ± 0.4 −2.2 ± 0.4* 138.5 ± 0.8 −2.2 ± 1.0* 
Subgroup analyses BL (nAMΔ BL (nAMΔ BL (nAMΔ 
    A1C (%)       
BL A1C ≤8.0% 7.6 (533) −0.6 ± 0.0* 7.6 (410) −0.6 ± 0.1* 7.6 (123) −0.7 ± 0.1* 
BL A1C >8.0% 9.2 (936) −1.3 ± 0.1* 9.2 (821) −1.2 ± 0.1* 9.0 (115) −1.4 ± 0.1* 
BL A1C ≤9.0% 8.1 (995) −0.8 ± 0.0* 8.1 (806) −0.7 ± 0.0* 7.9 (189) −0.9 ± 0.1* 
BL A1C >9.0% 9.9 (474) −1.6 ± 0.1* 9.9 (425) −1.6 ± 0.1* 9.7 (49) −1.7 ± 0.2* 
BL BMI <30 kg/m2 8.7 (613) −1.2 ± 0.1* 8.8 (487) −1.2 ± 0.1* 8.4 (126) −1.3 ± 0.1* 
BL BMI ≥30 kg/m2 8.6 (855) −0.9 ± 0.1* 8.7 (743) −0.9 ± 0.1* 8.2 (112) −1.0 ± 0.1* 
BL BMI <35 kg/m2 8.7 (1,034) −1.1 ± 0.0* 8.8 (838) −1.1 ± 0.1* 8.3 (196) −1.2 ± 0.1* 
BL BMI ≥35 kg/m2 8.6 (434) −0.9 ± 0.1* 8.6 (392) −0.9 ± 0.1* 8.2 (42) −0.9 ± 0.2* 
    Body weight (kg)       
BL BMI <30 kg/m2 75.6 (613) −0.0 ± 0.1 75.8 (487) 0.1 ± 0.1 74.5 (126) −0.5 ± 0.3 
BL BMI ≥30 kg/m2 101.3 (855) −0.6 ± 0.2* 102.6 (743) −0.5 ± 0.2* 93.3 (112) −1.3 ± 0.4* 
BL BMI <35 kg/m2 82.1 (1,034) −0.2 ± 0.1 82.8 (838) −0.1 ± 0.1 79.4 (196) −0.8 ± 0.2* 
BL BMI ≥35 kg/m2 110.7 (434) −0.6 ± 0.3* 111.7 (392) −0.6 ± 0.3* 101.8 (42) −1.4 ± 0.7* 

Data are means ± SE unless otherwise indicated.

*

P < 0.05 vs. baseline (within group);

P < 0.05 vs. younger subgroup.

Patients with both baseline A1C ≥7% and an end point value. BL, baseline.

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