Table 3—

Multivariate models of hyperglycemic progression

Model A
Model B
Model C
Model D
OR95% CIP valueOR95% CIP valueOR95% CIP valueOR95% CIP value
Progressed to original IFG — — — 3.11 2.43–3.98 <0.0001 — — — — — — 
Initially added IFG — — — — — — 1.12 0.88–1.42 0.352 — — — 
Initially original IFG — — — — — — — — — 1.61 1.12–2.32 0.010 
Initial FPG in stage (mg/dl) 1.08 1.05–1.12 <0.0001 1.08 1.04–1.13 0.0003 1.07 1.04–1.10 <0.0001 1.07 1.04–1.10 <0.0001 
Age (per 10 years) 0.98 0.93–1.02 0.311 0.92 0.86–0.99 0.020 0.92 0.87–0.98 0.015 0.92 0.88–0.97 0.002 
Female sex 1.05 0.87–1.28 0.611 1.47 1.11–1.93 0.007 1.33 1.02–1.72 0.032 1.44 1.17–1.77 0.781 
History of CVD 1.28 1.05–1.55 0.013 0.90 0.68–1.19 0.455 0.99 0.76–1.30 0.959 1.03 0.83–1.28 0.781 
Current smoker 0.99 0.80–1.23 0.944 1.51 1.15–1.99 0.003 1.17 0.89–1.53 0.255 1.24 1.00–1.54 0.047 
BMI (kg/m2) 1.03 1.02–1.05 <0.0001 1.04 1.02–1.06 <0.0001 1.03 1.02–1.05 <0.0001 1.04 1.03–1.06 <0.0001 
Systolic BP (per 5 mmHg) 1.04 1.00–1.08 0.066 1.10 1.04–1.16 <0.0001 1.08 1.03–1.14 0.001 1.09 1.05–1.14 <0.0001 
HDL cholesterol (per 5 mg/dl) 0.93 0.89–0.96 0.0001 0.88 0.83–0.93 <0.0001 0.88 0.84–0.93 <0.0001 0.87 0.84–0.91 <0.0001 
LDL cholesterol (per 5 mg/dl) 1.01 0.99–1.02 0.340 0.97 0.95–0.99 0.003 0.99 0.97–1.01 0.411 1.02 0.97–1.00 0.030 
Triglycerides (per 50 mg/dl) 1.01 1.00–1.02 0.002 1.01 1.00–1.02 0.026 1.03 1.01–1.04 0.0003 1.01 1.01–1.02 0.001 
Model A
Model B
Model C
Model D
OR95% CIP valueOR95% CIP valueOR95% CIP valueOR95% CIP value
Progressed to original IFG — — — 3.11 2.43–3.98 <0.0001 — — — — — — 
Initially added IFG — — — — — — 1.12 0.88–1.42 0.352 — — — 
Initially original IFG — — — — — — — — — 1.61 1.12–2.32 0.010 
Initial FPG in stage (mg/dl) 1.08 1.05–1.12 <0.0001 1.08 1.04–1.13 0.0003 1.07 1.04–1.10 <0.0001 1.07 1.04–1.10 <0.0001 
Age (per 10 years) 0.98 0.93–1.02 0.311 0.92 0.86–0.99 0.020 0.92 0.87–0.98 0.015 0.92 0.88–0.97 0.002 
Female sex 1.05 0.87–1.28 0.611 1.47 1.11–1.93 0.007 1.33 1.02–1.72 0.032 1.44 1.17–1.77 0.781 
History of CVD 1.28 1.05–1.55 0.013 0.90 0.68–1.19 0.455 0.99 0.76–1.30 0.959 1.03 0.83–1.28 0.781 
Current smoker 0.99 0.80–1.23 0.944 1.51 1.15–1.99 0.003 1.17 0.89–1.53 0.255 1.24 1.00–1.54 0.047 
BMI (kg/m2) 1.03 1.02–1.05 <0.0001 1.04 1.02–1.06 <0.0001 1.03 1.02–1.05 <0.0001 1.04 1.03–1.06 <0.0001 
Systolic BP (per 5 mmHg) 1.04 1.00–1.08 0.066 1.10 1.04–1.16 <0.0001 1.08 1.03–1.14 0.001 1.09 1.05–1.14 <0.0001 
HDL cholesterol (per 5 mg/dl) 0.93 0.89–0.96 0.0001 0.88 0.83–0.93 <0.0001 0.88 0.84–0.93 <0.0001 0.87 0.84–0.91 <0.0001 
LDL cholesterol (per 5 mg/dl) 1.01 0.99–1.02 0.340 0.97 0.95–0.99 0.003 0.99 0.97–1.01 0.411 1.02 0.97–1.00 0.030 
Triglycerides (per 50 mg/dl) 1.01 1.00–1.02 0.002 1.01 1.00–1.02 0.026 1.03 1.01–1.04 0.0003 1.01 1.01–1.02 0.001 

Model A: progression from added to original IFG; Model B: progression from added IFG to diabetes; Model C: progression from original IFG to diabetes; Model D: progression from either stage to diabetes. BP, blood pressure; CVD, cardiovascular disease; OR, odds ratio.

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