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Table 3—

Cox regression models relating metabolic syndrome and measures of insulin resistance to microvascular risk

VariableRetinopathyP valueNephropathyP value
Metabolic syndrome 0.85 (061–1.18) 0.33 0.98 (0.71–1.35) 0.91 
eGDR 0.75 (0.69–0.81) <0.001 0.88 (0.80–0.96) 0.005 
Insulin dose 0.77 (0.41–1.45) 0.42 1.61 (0.93–2.82) 0.09 
VariableRetinopathyP valueNephropathyP value
Metabolic syndrome 0.85 (061–1.18) 0.33 0.98 (0.71–1.35) 0.91 
eGDR 0.75 (0.69–0.81) <0.001 0.88 (0.80–0.96) 0.005 
Insulin dose 0.77 (0.41–1.45) 0.42 1.61 (0.93–2.82) 0.09 

Data are HR (95% CI). Units for eGDR are mg · kg−1 · min−1 and for insulin dose are units per kilogram body weight. Models adjusted for the following baseline covariates: age, sex, disease duration, randomization treatment (conventional/intensive), and prevention cohort (primary/secondary).

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