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Table 1—

Clinical features of patients with diabetes and deafness not carrying the m.3243A>G mutation

Mitochondrial DNA genotypePercentage heteroplasmy in muscleYears that deafness preceded diabetesClinical features at time of presentation with diabetes
m.8344A>G 90 13 Ptosis/dysarthria/ataxia 
m.12258C>A 85 None 
m.12258C>A 68 16 Mild constipation/dysarthria/fatigue 
Single mtDNA deletion ND Ptosis/CPEO/dysarthria/ataxia 
Single mtDNA deletion 50 12 Ptosis/CPEO/dysarthria/ataxia 
Single mtDNA deletion ND 15 Ptosis/dysarthria/mild ataxia 
Single mtDNA deletion 10 Fatigue 
Multiple mtDNA deletions NA Ptosis/CPEO/dysarthria/ataxia 
Mitochondrial DNA genotypePercentage heteroplasmy in muscleYears that deafness preceded diabetesClinical features at time of presentation with diabetes
m.8344A>G 90 13 Ptosis/dysarthria/ataxia 
m.12258C>A 85 None 
m.12258C>A 68 16 Mild constipation/dysarthria/fatigue 
Single mtDNA deletion ND Ptosis/CPEO/dysarthria/ataxia 
Single mtDNA deletion 50 12 Ptosis/CPEO/dysarthria/ataxia 
Single mtDNA deletion ND 15 Ptosis/dysarthria/mild ataxia 
Single mtDNA deletion 10 Fatigue 
Multiple mtDNA deletions NA Ptosis/CPEO/dysarthria/ataxia 

CPEO, chronic progressive external ophthalmoplegia; NA, not applicable; ND, not determined.

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