Table 2—

SFRs and corresponding 95% CIs among women first hospitalized for type 1 diabetes at age ≤16 years, stratified by calendar year and age at first hospitalization, calendar year and age at follow-up, or type of complications,1965–2004, Sweden

Live births
SFR (95% CI)
ExpectedObserved
Total 5,040 4,013 0.80 (0.77–0.82) 
Age at first hospitalization for type 1 diabetes    
    ≥5 years 393 319 0.81 (0.72–0.91) 
    6–10 years 1,372 1,122 0.82 (0.77–0.87) 
    11–16 years 3,275 2,572 0.79 (0.76–0.82) 
    Ptrend   0.30 
Calendar period at first hospitalization for type 1 diabetes    
    1965–1969 408 237 0.58 (0.51–0.66) 
    1970–1974 1,001 686 0.69 (0.63–0.74) 
    1975–1979 1,486 1,114 0.75 (0.71–0.80) 
    1980–1984 1,253 1,087 0.87 (0.82–0.92) 
    1985–1989 694 671 0.97 (0.89–1.04) 
    1990–1994 166 189 1.14 (0.98–1.31) 
    1995–2004 31 29 0.92 (0.62–1.32) 
    Ptrend   <0.01 
Calendar period at follow-up    
    1965–1979 212 158 0.75 (0.63–0.87) 
    1980–1989 1,014 688 0.68 (0.63–0.73) 
    1990–1999 2,368 1,916 0.81 (0.77–0.85) 
    2000–2004 1,446 1,251 0.87 (0.82–0.91) 
    Ptrend   <0.01 
Attained age at follow-up    
    16–19 years 205 184 0.90 (0.77–1.04) 
    20–24 years 1,327 1,158 0.87 (0.82–0.92) 
    25–29 years 1,925 1,569 0.82 (0.78–0.86) 
    30–34 years 1,215 873 0.72 (0.67–0.77) 
    35–39 years 332 209 0.63 (0.55–0.72) 
    40–48 years 35 20 0.57 (0.35–0.88) 
    Ptrend   <0.01 
Diabetic retinopathy*    
    No 4,009 3,364 0.84 (0.81–0.87) 
    Yes 1,030 649 0.63 (0.58–0.68) 
Diabetic nephropathy*    
    No 4,660 3,807 0.82 (0.79–0.84) 
    Yes 380 206 0.54 (0.47–0.62) 
Diabetic neuropathy*    
    No 4,837 3,911 0.81 (0.78–0.83) 
    Yes 203 102 0.50 (0.41–0.61) 
Cardiovascular complications*    
    No 4,970 3,989 0.80 (0.78–0.83) 
    Yes 70 24 0.34 (0.22–0.51) 
Live births
SFR (95% CI)
ExpectedObserved
Total 5,040 4,013 0.80 (0.77–0.82) 
Age at first hospitalization for type 1 diabetes    
    ≥5 years 393 319 0.81 (0.72–0.91) 
    6–10 years 1,372 1,122 0.82 (0.77–0.87) 
    11–16 years 3,275 2,572 0.79 (0.76–0.82) 
    Ptrend   0.30 
Calendar period at first hospitalization for type 1 diabetes    
    1965–1969 408 237 0.58 (0.51–0.66) 
    1970–1974 1,001 686 0.69 (0.63–0.74) 
    1975–1979 1,486 1,114 0.75 (0.71–0.80) 
    1980–1984 1,253 1,087 0.87 (0.82–0.92) 
    1985–1989 694 671 0.97 (0.89–1.04) 
    1990–1994 166 189 1.14 (0.98–1.31) 
    1995–2004 31 29 0.92 (0.62–1.32) 
    Ptrend   <0.01 
Calendar period at follow-up    
    1965–1979 212 158 0.75 (0.63–0.87) 
    1980–1989 1,014 688 0.68 (0.63–0.73) 
    1990–1999 2,368 1,916 0.81 (0.77–0.85) 
    2000–2004 1,446 1,251 0.87 (0.82–0.91) 
    Ptrend   <0.01 
Attained age at follow-up    
    16–19 years 205 184 0.90 (0.77–1.04) 
    20–24 years 1,327 1,158 0.87 (0.82–0.92) 
    25–29 years 1,925 1,569 0.82 (0.78–0.86) 
    30–34 years 1,215 873 0.72 (0.67–0.77) 
    35–39 years 332 209 0.63 (0.55–0.72) 
    40–48 years 35 20 0.57 (0.35–0.88) 
    Ptrend   <0.01 
Diabetic retinopathy*    
    No 4,009 3,364 0.84 (0.81–0.87) 
    Yes 1,030 649 0.63 (0.58–0.68) 
Diabetic nephropathy*    
    No 4,660 3,807 0.82 (0.79–0.84) 
    Yes 380 206 0.54 (0.47–0.62) 
Diabetic neuropathy*    
    No 4,837 3,911 0.81 (0.78–0.83) 
    Yes 203 102 0.50 (0.41–0.61) 
Cardiovascular complications*    
    No 4,970 3,989 0.80 (0.78–0.83) 
    Yes 70 24 0.34 (0.22–0.51) 

The age- and calendar year–matched Swedish women at large were used as a reference population. The SFRs are thus inherently adjusted for attained age and calendar year.

*

Person-time experienced before the onset of complications was allocated to the complication-negative strata.

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