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Table 1—

Clinical features of women with PCOS and control subjects

ControlPCOS
n 187 287 
Age (years) 33.0 (17.0) 27.5 (11.5)* 
BMI (kg/m224.1 (6.4) 34.7 (13.5)* 
WHR 0.78 (0.08) 0.83 (0.10)* 
mFG score 0 (0) 7.0 (5.0)* 
Hirsute (%) 73.9* 
Total testosterone (nmol/l) 1.42 (0.92) 2.77 (1.07)* 
Free testosterone (pmol/l) 12.1 (9.0) 29.1 (16.3)* 
DHEAS (μmol/l) 2.58 (2.03) 5.66 (4.61)* 
SHBG (nmol/l) 220.0 (120.0) 150.0 (70.0)* 
Insulin (pmol/l) 49.5 (45.9) 129.15 (129.2)* 
Glucose (mmol/l) 4.77 (0.56) 4.77 (0.72) 
HOMA-IR 0.92 (0.83) 2.29 (1.93)* 
HOMA-%B 103.9 (59.5) 175.3 (99.3)* 
ControlPCOS
n 187 287 
Age (years) 33.0 (17.0) 27.5 (11.5)* 
BMI (kg/m224.1 (6.4) 34.7 (13.5)* 
WHR 0.78 (0.08) 0.83 (0.10)* 
mFG score 0 (0) 7.0 (5.0)* 
Hirsute (%) 73.9* 
Total testosterone (nmol/l) 1.42 (0.92) 2.77 (1.07)* 
Free testosterone (pmol/l) 12.1 (9.0) 29.1 (16.3)* 
DHEAS (μmol/l) 2.58 (2.03) 5.66 (4.61)* 
SHBG (nmol/l) 220.0 (120.0) 150.0 (70.0)* 
Insulin (pmol/l) 49.5 (45.9) 129.15 (129.2)* 
Glucose (mmol/l) 4.77 (0.56) 4.77 (0.72) 
HOMA-IR 0.92 (0.83) 2.29 (1.93)* 
HOMA-%B 103.9 (59.5) 175.3 (99.3)* 

Data are median (interquartile range).

*

P < 0.001 compared with control group.

SHBG activity was measured by competitive binding analysis using Sephadex G-25 and [3H]testosterone as the ligand; this assay gives values of approximately 100–300 nmol/l in normal adult women. DHEAS, dehydroepiandrosterone sulfate; HOMA-%B, β-cell function estimated by the homeostasis model assessment; HOMA-IR, insulin resistance estimated by the homeostasis model assessment; mFG score, modified Ferriman-Gallwey hirsutism score; SHBG, sex hormone–binding globulin; WHR, waist-to-hip ratio.

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