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Table 2—

Biochemical changes by treatment group and baseline metabolic syndrome, excluding those with diabetes at baseline

Baseline
2 Years
4 Years
With MetSWithout MetSWith MetSWithout MetSWith MetSWithout MetS
Cholesterol (mg/dl)       
    Chlorthalidone 218.6 ± 43.2 (3,689) 214.9 ± 39.9 (4,357) 205.4 ± 40.7 (2,650) 206.6 ± 40.1 (3,033) 197.0 ± 41.0 (2,295) 199.2 ± 39.6 (2,535) 
    Amlodipine 220.8 ± 44.9 (2,112) 213.2 ± 40.7 (2,595) 204.5 ± 43.1 (1,507) 201.4 ± 40.2 (1,802)* 197.0 ± 40.9 (1,315) 194.7 ± 37.8 (1,525)* 
    Lisinopril 219.8 ± 42.5 (2,212) 212.9 ± 39.3 (2,550) 204.6 ± 41.7 (1,467) 201.2 ± 40.2 (1,698)* 196.6 ± 38.5 (1,248) 195.8 ± 37.6 (1,381) 
Potassium (mmol/l)       
    Chlorthalidone 4.3 ± 0.7 (3,689) 4.3 ± 0.7 (4,353) 4.0 ± 0.7 (2,566) 4.0 ± 0.7 (2,949) 4.1 ± 0.6 (2,246) 4.1 ± 0.8 (2,489) 
    Amlodipine 4.3 ± 0.7 (2,111) 4.3 ± 0.7 (2,594) 4.3 ± 0.6 (1,476)* 4.3 ± 0.7 (1,737)* 4.4 ± 0.7 (1,297)* 4.4 ± 0.8 (1,494)* 
    Lisinopril 4.3 ± 0.6 (2,210) 4.4 ± 0.7 (2,550) 4.5 ± 0.7 (1,413)* 4.5 ± 0.6 (1,617)* 4.5 ± 0.7 (1,228)* 4.5 ± 0.6 (1,361)* 
Fasting glucose (mg/dl)       
    Chlorthalidone 97.4 ± 12.1 (3,185) 89.3 ± 9.9 (3,587) 108.1 ± 31.4 (1,664) 96.5 ± 21.0 (1,812) 110.3 ± 32.9 (1,404) 100.2 ± 24.5 (1,541) 
    Amlodipine 97.2 ± 11.9 (1,849) 89.3 ± 9.7 (2,113) 104.9 ± 28.8 (928) 94.3 ± 16.4 (1,096) 110.0 ± 34.0 (833) 96.7 ± 17.8 (918)* 
    Lisinopril 97.5 ± 12.4 (1,959) 89.5 ± 9.9 (2,150) 101.5 ± 22.7 (906)* 93.7 ± 18.0 (1,027)* 105.7 ± 26.0 (779)* 96.2 ± 17.4 (832)* 
Fasting glucose ≥126 mg/dl (%)       
    Chlorthalidone 0.0 0.0 14.8 4.6 17.1 7.7 
    Amlodipine 0.0 0.0 12.9 3.6 16.0 4.2 
    Lisinopril 0.0 0.0 9.9* 2.7 12.6 4.7 
Estimated GFR (ml/min per 1.73 m2)       
    Chlorthalidone 74.4 ± 17.3 (3,689) 77.0 ± 18.7 (4,353) 71.9 ± 17.8 (2,566) 72.9 ± 19.0 (2,949) 69.2 ± 18.3 (2,246) 70.7 ± 18.8 (2,489) 
    Amlodipine 75.2 ± 17.8 (2,111) 77.2 ± 18.1 (2,594) 75.9 ± 18.4 (1,476)* 77.5 ± 19.1 (1,737)* 74.0 ± 19.5 (1,298)* 75.0 ± 19.2 (1,495)* 
    Lisinopril 75.1 ± 18.1 (2,210) 76.8 ± 18.6 (2,550) 72.1 ± 18.2 (1,413) 73.8 ± 19.4 (1,617) 69.8 ± 18.5 (1,230) 71.1 ± 18.8 (1,361) 
Baseline
2 Years
4 Years
With MetSWithout MetSWith MetSWithout MetSWith MetSWithout MetS
Cholesterol (mg/dl)       
    Chlorthalidone 218.6 ± 43.2 (3,689) 214.9 ± 39.9 (4,357) 205.4 ± 40.7 (2,650) 206.6 ± 40.1 (3,033) 197.0 ± 41.0 (2,295) 199.2 ± 39.6 (2,535) 
    Amlodipine 220.8 ± 44.9 (2,112) 213.2 ± 40.7 (2,595) 204.5 ± 43.1 (1,507) 201.4 ± 40.2 (1,802)* 197.0 ± 40.9 (1,315) 194.7 ± 37.8 (1,525)* 
    Lisinopril 219.8 ± 42.5 (2,212) 212.9 ± 39.3 (2,550) 204.6 ± 41.7 (1,467) 201.2 ± 40.2 (1,698)* 196.6 ± 38.5 (1,248) 195.8 ± 37.6 (1,381) 
Potassium (mmol/l)       
    Chlorthalidone 4.3 ± 0.7 (3,689) 4.3 ± 0.7 (4,353) 4.0 ± 0.7 (2,566) 4.0 ± 0.7 (2,949) 4.1 ± 0.6 (2,246) 4.1 ± 0.8 (2,489) 
    Amlodipine 4.3 ± 0.7 (2,111) 4.3 ± 0.7 (2,594) 4.3 ± 0.6 (1,476)* 4.3 ± 0.7 (1,737)* 4.4 ± 0.7 (1,297)* 4.4 ± 0.8 (1,494)* 
    Lisinopril 4.3 ± 0.6 (2,210) 4.4 ± 0.7 (2,550) 4.5 ± 0.7 (1,413)* 4.5 ± 0.6 (1,617)* 4.5 ± 0.7 (1,228)* 4.5 ± 0.6 (1,361)* 
Fasting glucose (mg/dl)       
    Chlorthalidone 97.4 ± 12.1 (3,185) 89.3 ± 9.9 (3,587) 108.1 ± 31.4 (1,664) 96.5 ± 21.0 (1,812) 110.3 ± 32.9 (1,404) 100.2 ± 24.5 (1,541) 
    Amlodipine 97.2 ± 11.9 (1,849) 89.3 ± 9.7 (2,113) 104.9 ± 28.8 (928) 94.3 ± 16.4 (1,096) 110.0 ± 34.0 (833) 96.7 ± 17.8 (918)* 
    Lisinopril 97.5 ± 12.4 (1,959) 89.5 ± 9.9 (2,150) 101.5 ± 22.7 (906)* 93.7 ± 18.0 (1,027)* 105.7 ± 26.0 (779)* 96.2 ± 17.4 (832)* 
Fasting glucose ≥126 mg/dl (%)       
    Chlorthalidone 0.0 0.0 14.8 4.6 17.1 7.7 
    Amlodipine 0.0 0.0 12.9 3.6 16.0 4.2 
    Lisinopril 0.0 0.0 9.9* 2.7 12.6 4.7 
Estimated GFR (ml/min per 1.73 m2)       
    Chlorthalidone 74.4 ± 17.3 (3,689) 77.0 ± 18.7 (4,353) 71.9 ± 17.8 (2,566) 72.9 ± 19.0 (2,949) 69.2 ± 18.3 (2,246) 70.7 ± 18.8 (2,489) 
    Amlodipine 75.2 ± 17.8 (2,111) 77.2 ± 18.1 (2,594) 75.9 ± 18.4 (1,476)* 77.5 ± 19.1 (1,737)* 74.0 ± 19.5 (1,298)* 75.0 ± 19.2 (1,495)* 
    Lisinopril 75.1 ± 18.1 (2,210) 76.8 ± 18.6 (2,550) 72.1 ± 18.2 (1,413) 73.8 ± 19.4 (1,617) 69.8 ± 18.5 (1,230) 71.1 ± 18.8 (1,361) 

Data are means ± SD (n) unless otherwise indicated.

*

P < 0.001 compared with chlorthalidone;

P < 0.05 compared with chlorthalidone.

Simplified four-variable MDRD study formula (ref. 17). MetS, metabolic syndrome.

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