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Table 2—

β-Coefficients for the clinical, clinical + biological, and clinical + biological + genetic equations: the DESIR study

Clinical equation
Clinical + biological equation
Clinical + biological + genetic equation
n = 1,860 men (140 with diabetes) and n = 1,954 women (63 with diabetes)
n = 1,860 men (140 with diabetes) and n = 1,954 women (63 with diabetes)
n = 1,655 men (128 with diabetes) and n = 1,740 women (58 with diabetes)
βPβPβP
Men       
    Intercept −10.45  −10.53  10.91  
    Current smoker 0.72 0.0002 0.88 0.0001 0.94 0.0001 
    Waist circumference (cm) 0.081 0.0001 0.060 0.0001 0.060 0.0001 
    Hypertension* 0.50 0.01     
    Fasting glucose (mmol/l)   10.15 0.0001 10.17 0.0001 
    Fasting glucose2   24.16 0.002 22.42 0.007 
    GGT (IU/l)   0.39 0.01 0.42 0.007 
    Number of TCF7L2 and IL6 deleterious alleles     0.14 0.2 
    AROC statistic 0.733  0.850  0.851  
    Hosmer-Lemeshow fit test  0.7  0.8  0.1 
Women       
    Intercept −11.81  −18.91  −20.43  
    Diabetes in the family 1.09 0.0001 0.80 0.01 0.75 0.02 
    Waist circumference (cm) 0.095 0.0001     
    BMI (kg/m2)   4.38 0.0001 4.69 0.0001 
    Hypertension* 0.64 0.03     
    Fasting glucose (mmol/l)   9.66 0.001 9.35 0.001 
    Fasting glucose2   23.89 0.06 22.39 0.08 
    Triglycerides (mmol/l)   0.95 0.003 0.86 0.01 
    Number of TCF7L2 amd IL6 deleterious alleles     0.36 0.04 
    AROC statistic 0.839  0.917  0.912  
    Hosmer-Lemeshow fit test  0.6  0.9  0.8 
Clinical equation
Clinical + biological equation
Clinical + biological + genetic equation
n = 1,860 men (140 with diabetes) and n = 1,954 women (63 with diabetes)
n = 1,860 men (140 with diabetes) and n = 1,954 women (63 with diabetes)
n = 1,655 men (128 with diabetes) and n = 1,740 women (58 with diabetes)
βPβPβP
Men       
    Intercept −10.45  −10.53  10.91  
    Current smoker 0.72 0.0002 0.88 0.0001 0.94 0.0001 
    Waist circumference (cm) 0.081 0.0001 0.060 0.0001 0.060 0.0001 
    Hypertension* 0.50 0.01     
    Fasting glucose (mmol/l)   10.15 0.0001 10.17 0.0001 
    Fasting glucose2   24.16 0.002 22.42 0.007 
    GGT (IU/l)   0.39 0.01 0.42 0.007 
    Number of TCF7L2 and IL6 deleterious alleles     0.14 0.2 
    AROC statistic 0.733  0.850  0.851  
    Hosmer-Lemeshow fit test  0.7  0.8  0.1 
Women       
    Intercept −11.81  −18.91  −20.43  
    Diabetes in the family 1.09 0.0001 0.80 0.01 0.75 0.02 
    Waist circumference (cm) 0.095 0.0001     
    BMI (kg/m2)   4.38 0.0001 4.69 0.0001 
    Hypertension* 0.64 0.03     
    Fasting glucose (mmol/l)   9.66 0.001 9.35 0.001 
    Fasting glucose2   23.89 0.06 22.39 0.08 
    Triglycerides (mmol/l)   0.95 0.003 0.86 0.01 
    Number of TCF7L2 amd IL6 deleterious alleles     0.36 0.04 
    AROC statistic 0.839  0.917  0.912  
    Hosmer-Lemeshow fit test  0.6  0.9  0.8 
*

Systolic/diastolic blood pressure ≥140/90 mmHg or medication for hypertension.

Fasting glucose, GGT, BMI, and triglycerides were log transformed.

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