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Table 1—

Characteristics of patients in cohort 1 and cohort 2

CharacteristicsCohort 1Cohort 2Pooled
n 661 607 1,268 
Age (years) 50.2 ± 8.0 50.5 ± 8.6 50.4 ± 8.3 
Men (%) 54.8 54.0 54.4 
Age at diagnosis (years)* 49.0 ± 7.8 49.1 ± 8.5 49.1 ± 8.1 
Duration of diabetes (months)* 14.2 ± 19.9 14.6 ± 22.3 14.4 ± 20.9 
BMI (kg/m224.9 ± 2.9 24.3 ± 3.4 24.9 ± 8.4 
Waist circumference (cm) 88.7 ± 9.0 86.7 ± 9.5 87.8 ± 9.3 
Baseline    
    FPG(mmol/l) 10.8 ± 2.6 11.4 ± 3.2 11.1 ± 2.9 
    2-h plasma glucose (mmol/l) 18.9 ± 4.4 18.3 ± 5.0 18.6 ± 4.7 
    A1C (%)§ 8.5 ± 1.8 8.3 ± 2.1 8.1 ± 1.9 
    Fasting insulin (μIU/ml) 6.7 ± 2.0 5.0 ± 2.2 5.5 ± 2.2 
    HOMA-B 20.1 ± 2.0 14.9 ± 2.5 18.2 ± 2.2 
    HOMA-IR 1.0 ± 2.0 0.8 ± 2.0 0.9 ± 2.0 
    Total cholesterol (mmol/l) 5.1 ± 1.1 5.2 ± 1.6 5.2 ± 1.4 
    HDL cholesterol (mmol/l) 1.3 ± 0.4 1.5 ± 3.2 1.4 ± 2.2 
    Triglyceride (mmol/l) 2.2 ± 1.6 2.0 ± 1.9 2.1 ± 1.7 
FPG at day 29 (mmol/l) 7.9 ± 2.1 8.1 ± 2.4 8.0 ± 2.3 
At day 57    
    FPG(mmol/l) 7.7 ± 2.1 7.7 ± 2.4 7.7 ± 2.3** 
    2-h plasma glucose (mmol/l)†† 14.6 ± 4.4 13.9 ± 5.1 14.3 ± 4.7** 
    A1C (%)‡‡ 7.1 ± 1.3 6.6 ± 1.4 6.9 ± 1.3** 
    Fasting insulin (μIU/ml)§§ 7.4 ± 2.0 5.5 ± 2.5 6.7 ± 2.2** 
    HOMA-B§§ 44.7 ± 1.8 33.1 ± 2.5 40.4 ± 2.2** 
    HOMA-IR§§ 1.1 ± 2.0 0.8 ± 2.0 1.0 ± 2.0 
CharacteristicsCohort 1Cohort 2Pooled
n 661 607 1,268 
Age (years) 50.2 ± 8.0 50.5 ± 8.6 50.4 ± 8.3 
Men (%) 54.8 54.0 54.4 
Age at diagnosis (years)* 49.0 ± 7.8 49.1 ± 8.5 49.1 ± 8.1 
Duration of diabetes (months)* 14.2 ± 19.9 14.6 ± 22.3 14.4 ± 20.9 
BMI (kg/m224.9 ± 2.9 24.3 ± 3.4 24.9 ± 8.4 
Waist circumference (cm) 88.7 ± 9.0 86.7 ± 9.5 87.8 ± 9.3 
Baseline    
    FPG(mmol/l) 10.8 ± 2.6 11.4 ± 3.2 11.1 ± 2.9 
    2-h plasma glucose (mmol/l) 18.9 ± 4.4 18.3 ± 5.0 18.6 ± 4.7 
    A1C (%)§ 8.5 ± 1.8 8.3 ± 2.1 8.1 ± 1.9 
    Fasting insulin (μIU/ml) 6.7 ± 2.0 5.0 ± 2.2 5.5 ± 2.2 
    HOMA-B 20.1 ± 2.0 14.9 ± 2.5 18.2 ± 2.2 
    HOMA-IR 1.0 ± 2.0 0.8 ± 2.0 0.9 ± 2.0 
    Total cholesterol (mmol/l) 5.1 ± 1.1 5.2 ± 1.6 5.2 ± 1.4 
    HDL cholesterol (mmol/l) 1.3 ± 0.4 1.5 ± 3.2 1.4 ± 2.2 
    Triglyceride (mmol/l) 2.2 ± 1.6 2.0 ± 1.9 2.1 ± 1.7 
FPG at day 29 (mmol/l) 7.9 ± 2.1 8.1 ± 2.4 8.0 ± 2.3 
At day 57    
    FPG(mmol/l) 7.7 ± 2.1 7.7 ± 2.4 7.7 ± 2.3** 
    2-h plasma glucose (mmol/l)†† 14.6 ± 4.4 13.9 ± 5.1 14.3 ± 4.7** 
    A1C (%)‡‡ 7.1 ± 1.3 6.6 ± 1.4 6.9 ± 1.3** 
    Fasting insulin (μIU/ml)§§ 7.4 ± 2.0 5.5 ± 2.5 6.7 ± 2.2** 
    HOMA-B§§ 44.7 ± 1.8 33.1 ± 2.5 40.4 ± 2.2** 
    HOMA-IR§§ 1.1 ± 2.0 0.8 ± 2.0 1.0 ± 2.0 

Data are means ± SD.

*

The sample sizes of cohort 1, cohort 2, and total are 383, 291, and 674, respectively.

P < 0.05 compared with cohort 1.

The sample sizes of cohort 1, cohort 2, and total are 534, 429, and 963, respectively.

§

The sample sizes of cohort 1, cohort 2, and total are 378, 321, and 699, respectively.

Log transformed before the analysis; geometric mean and anti-log SD are presented.

The sample sizes of cohort 1, cohort 2, and total are 572, 465, and 1,037, respectively.

**

P < 0.05 compared with baseline, t test.

††

The sample sizes of cohort 1, cohort 2, and total are 646, 520, and 1,166, respectively.

‡‡

The sample sizes of cohort 1, cohort 2, and total are 460, 249, and 709, respectively.

§§

The sample sizes of cohort 1, cohort 2, and total are 598, 304, and 902, respectively.

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