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Table 2—

Glycemic and blood pressure in year 4 by 3-year weight change–trajectory pattern

Higher stable weightLower stable weightWeight lossWeight gainP*
A1C measurements      
    n (%) 322 (16.9) 1,135 (59.4) 227 (11.9) 227 (11.9)  
    Above-goal mean A1C (%) 153 (47.5) 472 (41.6) 63 (27.8) 118 (52.0) <0.0001 
    A1C (%) 7.2 ± 1.3c 7.0 ± 1.2ad 6.6 ± 1.1bcd 7.3 ± 1.4ab <0.0001 
        Median (IQR) 6.9 (6.3–7.8) 6.8 (6.2–7.5) 6.4 (5.8–7.1) 7.0 (6.2–78.0)  
    Mean A1C stratum (%)     <0.0001 
        <7 169 (52.5) 663 (58.4) 164 (72.2) 109 (48.0)  
        7–8 87 (27.0) 277 (24.4) 41 (18.1) 59 (26.0)  
        8–9 37 (11.5) 120 (10.6) 14 (6.2) 31 (13.7)  
        ≥9 29 (9.0) 75 (6.6) 8 (3.5) 28 (12.3)  
Blood pressure measurements      
    n (%) 396 (16.4) 1447 (60.1) 285 (11.8) 281 (11.7)  
    Above-goal mean blood pressure (mmHg) 291 (73.5) 893 (61.7) 172 (60.4) 189 (67.3) <0.0001 
    Systolic blood pressure (mmHg) 135.9 ± 12.9ab 132.9 ± 14.0a 131.6 ± 13.2b 133.4 ± 13.3 <0.0001 
        Median (IQR) 135 (127–144) 132 (123–141) 131 (122–139) 132 (125–140)  
    Diastolic blood pressure (mmHg) 80.1 ± 7.8ab 77.1 ± 8.2bd 77.4 ± 8.4ac 79.3 ± 8.3cd <0.0001 
        Median (IQR) 80 (75–85) 77 (71–82) 79 (72–82) 80 (74–84)  
    Mean systolic blood pressure stratum (mmHg)     0.0364 
        ≤130 143 (36.1) 650 (44.9) 135 (47.4) 133 (47.3)  
        130–139 110 (27.8) 389 (26.9) 81 (28.4) 69 (24.6)  
        140–159 125 (31.6) 355 (24.5) 61 (21.4) 69 (24.6)  
        ≥160 18 (4.5) 53 (3.7) 8 (2.8) 10 (3.5)  
    Mean diastolic blood pressure stratum (mmHg)     <0.0001 
        ≤80 198 (50.0) 970 (67.0) 182 (63.9) 151 (53.7)  
        80–89 155 (39.1) 385 (26.6) 82 (28.8) 104 (37.0)  
        90–99 40 (10.1) 84 (5.8) 19 (6.6) 24 (8.6)  
        ≥100 3 (0.8) 8 (0.6) 2 (0.7) 2 (0.7)  
Higher stable weightLower stable weightWeight lossWeight gainP*
A1C measurements      
    n (%) 322 (16.9) 1,135 (59.4) 227 (11.9) 227 (11.9)  
    Above-goal mean A1C (%) 153 (47.5) 472 (41.6) 63 (27.8) 118 (52.0) <0.0001 
    A1C (%) 7.2 ± 1.3c 7.0 ± 1.2ad 6.6 ± 1.1bcd 7.3 ± 1.4ab <0.0001 
        Median (IQR) 6.9 (6.3–7.8) 6.8 (6.2–7.5) 6.4 (5.8–7.1) 7.0 (6.2–78.0)  
    Mean A1C stratum (%)     <0.0001 
        <7 169 (52.5) 663 (58.4) 164 (72.2) 109 (48.0)  
        7–8 87 (27.0) 277 (24.4) 41 (18.1) 59 (26.0)  
        8–9 37 (11.5) 120 (10.6) 14 (6.2) 31 (13.7)  
        ≥9 29 (9.0) 75 (6.6) 8 (3.5) 28 (12.3)  
Blood pressure measurements      
    n (%) 396 (16.4) 1447 (60.1) 285 (11.8) 281 (11.7)  
    Above-goal mean blood pressure (mmHg) 291 (73.5) 893 (61.7) 172 (60.4) 189 (67.3) <0.0001 
    Systolic blood pressure (mmHg) 135.9 ± 12.9ab 132.9 ± 14.0a 131.6 ± 13.2b 133.4 ± 13.3 <0.0001 
        Median (IQR) 135 (127–144) 132 (123–141) 131 (122–139) 132 (125–140)  
    Diastolic blood pressure (mmHg) 80.1 ± 7.8ab 77.1 ± 8.2bd 77.4 ± 8.4ac 79.3 ± 8.3cd <0.0001 
        Median (IQR) 80 (75–85) 77 (71–82) 79 (72–82) 80 (74–84)  
    Mean systolic blood pressure stratum (mmHg)     0.0364 
        ≤130 143 (36.1) 650 (44.9) 135 (47.4) 133 (47.3)  
        130–139 110 (27.8) 389 (26.9) 81 (28.4) 69 (24.6)  
        140–159 125 (31.6) 355 (24.5) 61 (21.4) 69 (24.6)  
        ≥160 18 (4.5) 53 (3.7) 8 (2.8) 10 (3.5)  
    Mean diastolic blood pressure stratum (mmHg)     <0.0001 
        ≤80 198 (50.0) 970 (67.0) 182 (63.9) 151 (53.7)  
        80–89 155 (39.1) 385 (26.6) 82 (28.8) 104 (37.0)  
        90–99 40 (10.1) 84 (5.8) 19 (6.6) 24 (8.6)  
        ≥100 3 (0.8) 8 (0.6) 2 (0.7) 2 (0.7)  

Data are n (%) and means ± SD unless otherwise indicated.

*

Comparison across all 4 groups.

Includes those with one or more measures during year 4.

abcd

Means with the same superscripts are significantly different from one another at P < 0.05. IQR, interquartile range.

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