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Table 3—

Alcohol consumption (per 12.5 g/day), mediating biomarkers, and risk of type 2 diabetes among 787 control women and 705 women who developed type 2 diabetes

BMI adjusted
Not BMI adjusted
OR (95% CI)β coefficient% AttenuatedOR (95% CI)β coefficient% Attenuated
MV adjusted* 0.67 (0.56–0.79) −0.41 ± 0.09 — 0.58 (0.49–0.69) −0.55 ± 0.09  
    BMI NA NA NA 0.67 (0.56–0.79) −0.41 ± 0.09 25 
    CRP 0.67 (0.56–0.80) −0.41 ± 0.09 0.61 (0.51–0.72) −0.50 ± 0.09 
    VCAM-1 0.67 (0.56–0.80) −0.40 ± 0.09 0.59 (0.50–0.69) −0.54 ± 0.09 
    ICAM-1 0.67 (0.56–0.80) −0.40 ± 0.09 0.59 (0.49–0.69) −0.54 ± 0.09 
    E-selectin 0.67 (0.56–0.80) −0.41 ± 0.09 −1 0.59 (0.50–0.71) −0.52 ± 0.09 
    IL-6 0.67 (0.57–0.80) −0.40 ± 0.09 0.59 (0.50–0.70) −0.53 ± 0.09 
    TNF-R2 0.67 (0.56–0.80) −0.40 ± 0.09 0.60 (0.50–0.70) −0.52 ± 0.09 
MV adjusted* 0.71 (0.59–0.87) −0.34 ± 0.10  0.65 (0.53–0.79) −0.44 ± 0.10  
    Insulin 0.71 (0.58–0.87) −0.34 ± 0.10 0.67 (0.55–0.82) −0.41 ± 0.10 
MV adjusted* 0.71 (0.61–0.83) −0.35 ± 0.08  0.66 (0.56–0.77) −0.42 ± 0.08  
    Adiponectin 0.77 (0.65–0.91) −0.27 ± 0.08 24 0.74 (0.63–0.87) −0.30 ± 0.08 29 
BMI adjusted
Not BMI adjusted
OR (95% CI)β coefficient% AttenuatedOR (95% CI)β coefficient% Attenuated
MV adjusted* 0.67 (0.56–0.79) −0.41 ± 0.09 — 0.58 (0.49–0.69) −0.55 ± 0.09  
    BMI NA NA NA 0.67 (0.56–0.79) −0.41 ± 0.09 25 
    CRP 0.67 (0.56–0.80) −0.41 ± 0.09 0.61 (0.51–0.72) −0.50 ± 0.09 
    VCAM-1 0.67 (0.56–0.80) −0.40 ± 0.09 0.59 (0.50–0.69) −0.54 ± 0.09 
    ICAM-1 0.67 (0.56–0.80) −0.40 ± 0.09 0.59 (0.49–0.69) −0.54 ± 0.09 
    E-selectin 0.67 (0.56–0.80) −0.41 ± 0.09 −1 0.59 (0.50–0.71) −0.52 ± 0.09 
    IL-6 0.67 (0.57–0.80) −0.40 ± 0.09 0.59 (0.50–0.70) −0.53 ± 0.09 
    TNF-R2 0.67 (0.56–0.80) −0.40 ± 0.09 0.60 (0.50–0.70) −0.52 ± 0.09 
MV adjusted* 0.71 (0.59–0.87) −0.34 ± 0.10  0.65 (0.53–0.79) −0.44 ± 0.10  
    Insulin 0.71 (0.58–0.87) −0.34 ± 0.10 0.67 (0.55–0.82) −0.41 ± 0.10 
MV adjusted* 0.71 (0.61–0.83) −0.35 ± 0.08  0.66 (0.56–0.77) −0.42 ± 0.08  
    Adiponectin 0.77 (0.65–0.91) −0.27 ± 0.08 24 0.74 (0.63–0.87) −0.30 ± 0.08 29 
*

Multivariate (MV) models are adjusted for BMI, physical activity, smoking, family history of diabetes, postmenopausal hormone replacement therapy, energy intake, and energy-adjusted intake of saturated fat, trans fatty acids, polyunsaturated fat, dietary fiber, glycemic load, and coffee consumption. NA, not applicable.

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