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Table 3—

Crude incidence rate and adjusted HRs (95% CI) of cancer by TCF7L2 genotype (rs7903146 SNP), ARIC Study, 1987–2000

Cancer/genotypeNo. developing cancerPerson-yearsCrude incidence rateAge-, race-, and sex-adjusted HR (95% CI)Fully adjusted HR (95% CI)*
Colorectal cancer      
    CC 80 76,707 1.04 
    CT 79 63,470 1.24 1.21 (0.89–1.65) 1.17 (0.85–1.61) 
    TT 21 13,314 1.58 1.50 (0.93–2.43) 1.56 (0.97–2.53) 
    Ptrend     0.07 
Colon cancer      
    CC 54 76,841 0.70 
    CT 55 63,545 0.87 1.25 (0.86–1.82) 1.25 (0.85–1.83) 
    TT 19 13,320 1.43 2.02 (1.20–3.40) 2.15 (1.27–3.64) 
    Ptrend     0.009 
Lung cancer      
    Whites      
        CC 66 57,295 1.15 
        CT 90 47,139 1.91 1.69 (1.23–2.32) 1.63 (1.17–2.25) 
        TT 21 10,092 2.08 1.83 (1.12–2.99) 1.59 (0.96–2.63) 
        Ptrend     0.008 
    Blacks      
        CC 35 19,639 1.78 
        CT 22 16,459 1.34 0.75 (0.44–1.28) 0.75 (0.44–1.30) 
        TT 3,245 1.54 0.82 (0.32–2.10) 0.62 (0.22–1.76) 
        Ptrend     0.22 
Breast cancer (women)      
    CC 177 42,318 4.18 
    CT 139 34,187 4.07 0.98 (0.78–1.22) 0.98 (0.78–1.23) 
    TT 26 7,140 3.64 0.87 (0.58–1.31) 0.87 (0.57–1.32) 
    Ptrend     0.56 
Prostate cancer      
    CC 201 33,019 6.09 
    CT 131 28,401 4.61 0.78 (0.63–0.97) 0.80 (0.64–0.99) 
    TT 34 5,945 5.72 0.96 (0.67–1.38) 1.04 (0.72–1.50) 
    Ptrend     0.33 
Cancer/genotypeNo. developing cancerPerson-yearsCrude incidence rateAge-, race-, and sex-adjusted HR (95% CI)Fully adjusted HR (95% CI)*
Colorectal cancer      
    CC 80 76,707 1.04 
    CT 79 63,470 1.24 1.21 (0.89–1.65) 1.17 (0.85–1.61) 
    TT 21 13,314 1.58 1.50 (0.93–2.43) 1.56 (0.97–2.53) 
    Ptrend     0.07 
Colon cancer      
    CC 54 76,841 0.70 
    CT 55 63,545 0.87 1.25 (0.86–1.82) 1.25 (0.85–1.83) 
    TT 19 13,320 1.43 2.02 (1.20–3.40) 2.15 (1.27–3.64) 
    Ptrend     0.009 
Lung cancer      
    Whites      
        CC 66 57,295 1.15 
        CT 90 47,139 1.91 1.69 (1.23–2.32) 1.63 (1.17–2.25) 
        TT 21 10,092 2.08 1.83 (1.12–2.99) 1.59 (0.96–2.63) 
        Ptrend     0.008 
    Blacks      
        CC 35 19,639 1.78 
        CT 22 16,459 1.34 0.75 (0.44–1.28) 0.75 (0.44–1.30) 
        TT 3,245 1.54 0.82 (0.32–2.10) 0.62 (0.22–1.76) 
        Ptrend     0.22 
Breast cancer (women)      
    CC 177 42,318 4.18 
    CT 139 34,187 4.07 0.98 (0.78–1.22) 0.98 (0.78–1.23) 
    TT 26 7,140 3.64 0.87 (0.58–1.31) 0.87 (0.57–1.32) 
    Ptrend     0.56 
Prostate cancer      
    CC 201 33,019 6.09 
    CT 131 28,401 4.61 0.78 (0.63–0.97) 0.80 (0.64–0.99) 
    TT 34 5,945 5.72 0.96 (0.67–1.38) 1.04 (0.72–1.50) 
    Ptrend     0.33 
*

Adjusted for baseline age (continuous), race (white or black), BMI (continuous), smoking status (current smoker or nonsmoker), pack-years (continuous), ethanol intake (continuous), sport index (continuous), education (< high school graduate or ≥ high school graduate), sex, and current hormone replacement therapy (male, female with no hormone replacement therapy, or female with hormone replacement therapy).

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