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Table 2—

Prediction of diabetes by depression symptoms and antidepressant drug exposure

At baseline
During follow-up
BDI <11BDI ≥11No medicationsTaking medicationsBDI always <11BDI ever ≥11No medicationsIntermittent medicationsContinuous medications
PLB arm          
    Pyr 2,451.6 300.4 2,624.9 127.1 2,316.7 435.3 2,460.0 218.8 73.2 
    Cases 270 30 277 23 245 55 259 28 13 
    IR 11.0 10.0 10.6 18.1 10.6 12.6 10.5 12.8 17.8 
    HRu 0.90 (0.61–1.32) 1.80 (1.15–2.82) 1.11 (0.82–1.50) 1.17 (0.78–1.76) 1.80 (1.00–3.25) 
    HRa 0.84 (0.56–1.26) 2.25 (1.38–3.66) 0.99 (0.72–1.37) 1.50 (0.97–2.33) 2.60 (1.37–4.94) 
MET arm          
    Pyr 2,584.9 289.0 2,675.7 198.2 2,441.0 432.9 2,549.2 224.4 100.3 
    Cases 199 25 213 11 187 37 200 19 
    IR 7.7 8.7 8.0 5.5 7.7 8.5 7.8 8.5 5.0 
    HRu 1.14 (0.74–1.75) 0.69 (0.37–1.27) 1.00 (0.69–1.43) 0.96 (0.59–1.57) 0.68 (0.28–1.68) 
    HRa 1.07 (0.68–1.68) 0.72 (0.38–1.36) 0.91 (0.62–1.33) 0.99 (0.59–1.65) 0.71 (0.28–1.78) 
ILS arm          
    Pyr 2,711.2 299.9 2,863.5 147.6 2,577.2 433.9 2,733.4 178.7 99.0 
    Cases 130 21 134 17 120 31 123 19 
    IR 4.8 7.0 4.7 11.5 4.7 7.1 4.5 10.6 9.1 
    HRu 1.49 (0.93–2.39) 2.68 (1.59–4.52) 1.35 (0.90–2.02) 1.91 (1.15–3.19) 2.51 (1.29–4.89) 
    HRa 1.15 (0.69–1.93) 3.48 (1.93–6.28) 0.87 (0.56–1.39) 2.07 (1.18–3.62) 3.39 (1.61–7.13) 
At baseline
During follow-up
BDI <11BDI ≥11No medicationsTaking medicationsBDI always <11BDI ever ≥11No medicationsIntermittent medicationsContinuous medications
PLB arm          
    Pyr 2,451.6 300.4 2,624.9 127.1 2,316.7 435.3 2,460.0 218.8 73.2 
    Cases 270 30 277 23 245 55 259 28 13 
    IR 11.0 10.0 10.6 18.1 10.6 12.6 10.5 12.8 17.8 
    HRu 0.90 (0.61–1.32) 1.80 (1.15–2.82) 1.11 (0.82–1.50) 1.17 (0.78–1.76) 1.80 (1.00–3.25) 
    HRa 0.84 (0.56–1.26) 2.25 (1.38–3.66) 0.99 (0.72–1.37) 1.50 (0.97–2.33) 2.60 (1.37–4.94) 
MET arm          
    Pyr 2,584.9 289.0 2,675.7 198.2 2,441.0 432.9 2,549.2 224.4 100.3 
    Cases 199 25 213 11 187 37 200 19 
    IR 7.7 8.7 8.0 5.5 7.7 8.5 7.8 8.5 5.0 
    HRu 1.14 (0.74–1.75) 0.69 (0.37–1.27) 1.00 (0.69–1.43) 0.96 (0.59–1.57) 0.68 (0.28–1.68) 
    HRa 1.07 (0.68–1.68) 0.72 (0.38–1.36) 0.91 (0.62–1.33) 0.99 (0.59–1.65) 0.71 (0.28–1.78) 
ILS arm          
    Pyr 2,711.2 299.9 2,863.5 147.6 2,577.2 433.9 2,733.4 178.7 99.0 
    Cases 130 21 134 17 120 31 123 19 
    IR 4.8 7.0 4.7 11.5 4.7 7.1 4.5 10.6 9.1 
    HRu 1.49 (0.93–2.39) 2.68 (1.59–4.52) 1.35 (0.90–2.02) 1.91 (1.15–3.19) 2.51 (1.29–4.89) 
    HRa 1.15 (0.69–1.93) 3.48 (1.93–6.28) 0.87 (0.56–1.39) 2.07 (1.18–3.62) 3.39 (1.61–7.13) 

Data are hazard ratio(95% CI), unless otherwise indicated. Cases, incident cases of diabetes developing during follow-up. Pyr, person-years of follow-up. HRa, hazard ratio(from Cox proportional hazard model) with 95% CI, adjusted for age, sex, race/ethnicity, education, fasting plasma glucose, weight, and weight change. HRu, hazard ratio(from Cox proportional hazard model) with 95% CI, unadjusted for covariates. IR, incidence rate(cases/100 person-years of follow-up). In addition, depression symptom and antidepressant drug use are adjusted for each other.

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