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Table 2—

HRs (95% CI) of foot ulcer and LEA for the full dataset and for foot ulcer and LEA

A. Full datasetFoot ulcerFoot ulcer adjustedLEALEA adjusted (includes an interaction term for PAD)
CKD (eGFR)     
    ≥60 ml/min per 1.73 m2 Ref Ref Ref Ref 
    ≥30 to <60 ml/min per 1.73 m2 1.85 (1.71–2.01) 1.51 (1.38–1.66) 2.08 (1.68–2.58) 2.28 (1.54–3.36) 
    <30 ml/min per 1.73 m2 3.92 (3.23–4.75) 3.22 (2.60–4.00) 7.71 (5.29–1.26) 8.05 (4.23–7.01) 
A. Full datasetFoot ulcerFoot ulcer adjustedLEALEA adjusted (includes an interaction term for PAD)
CKD (eGFR)     
    ≥60 ml/min per 1.73 m2 Ref Ref Ref Ref 
    ≥30 to <60 ml/min per 1.73 m2 1.85 (1.71–2.01) 1.51 (1.38–1.66) 2.08 (1.68–2.58) 2.28 (1.54–3.36) 
    <30 ml/min per 1.73 m2 3.92 (3.23–4.75) 3.22 (2.60–4.00) 7.71 (5.29–1.26) 8.05 (4.23–7.01) 
B. Foot ulcerFoot ulcer without PADFoot ulcer without PAD adjustedFoot ulcer with PADFoot ulcer with PAD adjusted
CKD (eGFR)     
    ≥60 ml/min per 1.73 m2 Ref Ref Ref Ref 
    ≥30 to <60 ml/min per 1.73 m2 1.68 (1.51–1.86) 1.41 (1.24,1.58) 1.44 (1.26,1.65) 1.38 (1.18–1.60) 
    <30 ml/min per 1.73 m2 3.86 (3.00–4.98) 3.32 (2.55–4.33) 2.10 (1.56,2.84) 2.04 (1.49–2.79) 
B. Foot ulcerFoot ulcer without PADFoot ulcer without PAD adjustedFoot ulcer with PADFoot ulcer with PAD adjusted
CKD (eGFR)     
    ≥60 ml/min per 1.73 m2 Ref Ref Ref Ref 
    ≥30 to <60 ml/min per 1.73 m2 1.68 (1.51–1.86) 1.41 (1.24,1.58) 1.44 (1.26,1.65) 1.38 (1.18–1.60) 
    <30 ml/min per 1.73 m2 3.86 (3.00–4.98) 3.32 (2.55–4.33) 2.10 (1.56,2.84) 2.04 (1.49–2.79) 
C. LEALEA without PADLEA without PAD adjustedLEA with PADLEA with PAD adjusted
CKD (eGFR)     
    ≥60 ml/min per 1.73 m2 Ref Ref Ref Ref 
    ≥30 to <60 ml/min per 1.73 m2 1.82 (1.28–2.60) 2.05 (1.37–3.07) 1.31 (1.00–1.72)* 1.60 (1.19–2.16) 
    <30 ml/min per 1.73 m2 6.96 (3.50–13.83) 7.80 (3.82–15.90) 2.90 (1.76,4.76) 3.33 (1.93–5.77) 
C. LEALEA without PADLEA without PAD adjustedLEA with PADLEA with PAD adjusted
CKD (eGFR)     
    ≥60 ml/min per 1.73 m2 Ref Ref Ref Ref 
    ≥30 to <60 ml/min per 1.73 m2 1.82 (1.28–2.60) 2.05 (1.37–3.07) 1.31 (1.00–1.72)* 1.60 (1.19–2.16) 
    <30 ml/min per 1.73 m2 6.96 (3.50–13.83) 7.80 (3.82–15.90) 2.90 (1.76,4.76) 3.33 (1.93–5.77) 

Adjusted and unadjusted results are shown. Parts B and C include results in the presence or absence of peripheral arterial disease. Compared with reference (Ref) or as a test for trend, all P values <0.001 unless

*

P = 0.05.

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