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Table 2—

Mean ± SD skin autofluorescence at baseline and mean differences between groups

A: t0 absent/tfu absentB: t0 absent/tfu presentC: t0 present/tfu presentB vs. AC vs. AC vs. B
Microvascular complication       
Retinopathy 2.69 ± 0.73 2.88 ± 0.74 2.91 ± 0.72 0.20 0.22 0.02 
    n 647 61 169 (−0.04 to 0.43) (0.07–0.37) (−0.24 to 0.29) 
    P    0.14 0.002 1.00 
Neuropathy 2.67 ± 0.72 2.93 ± 0.75 2.88 ± 0.75 0.26 0.21 −0.05 
    n 596 66 215 (0.03–0.49) (0.07–0.35) (−0.29 to 0.20) 
    P    0.019 0.001 1.00 
(Micro)albuminuria 2.62 ± 0.68 2.91 ± 0.67 2.97 ± 0.83 0.28 0.34 0.06 
    n 570 87 207 (0.09–0.48) (0.20–0.48) (−0.16 to 0.28) 
    P    0.002 <0.001 1.00 
Any 2.52 ± 0.69 2.86 ± 0.66 2.88 ± 0.75 0.34 0.36 0.01 
    n 322 109 441 (0.15–0.53) (0.23–0.48) (−0.17 to 0.20) 
    P    <0.001 <0.001 1.00 
A: t0 absent/tfu absentB: t0 absent/tfu presentC: t0 present/tfu presentB vs. AC vs. AC vs. B
Microvascular complication       
Retinopathy 2.69 ± 0.73 2.88 ± 0.74 2.91 ± 0.72 0.20 0.22 0.02 
    n 647 61 169 (−0.04 to 0.43) (0.07–0.37) (−0.24 to 0.29) 
    P    0.14 0.002 1.00 
Neuropathy 2.67 ± 0.72 2.93 ± 0.75 2.88 ± 0.75 0.26 0.21 −0.05 
    n 596 66 215 (0.03–0.49) (0.07–0.35) (−0.29 to 0.20) 
    P    0.019 0.001 1.00 
(Micro)albuminuria 2.62 ± 0.68 2.91 ± 0.67 2.97 ± 0.83 0.28 0.34 0.06 
    n 570 87 207 (0.09–0.48) (0.20–0.48) (−0.16 to 0.28) 
    P    0.002 <0.001 1.00 
Any 2.52 ± 0.69 2.86 ± 0.66 2.88 ± 0.75 0.34 0.36 0.01 
    n 322 109 441 (0.15–0.53) (0.23–0.48) (−0.17 to 0.20) 
    P    <0.001 <0.001 1.00 

Data are means ± SD of skin autofluorescence in AUs within the group or mean differences between groups (95% CI) (ANOVA with Bonferroni correction). t0, baseline; tfu, follow-up.

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