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Table 2—

Multiple logistic regression analyses of the associations of adipokines with incident type 2 diabetes: the Sandy Lake Health and Diabetes Project

Independent variableSDModel 1*
Model 2
Model 3
OR (95% CI)POR (95% CI)POR (95% CI)P
Adiponectin 0.49 0.57 (0.44–0.73) <0.001 0.63 (0.48–0.83) 0.001 0.68 (0.51–0.90) 0.007 
Leptin 0.92 2.05 (1.44–2.90) <0.001 1.50 (1.02–2.21) 0.04 0.97 (0.58–1.62) 0.89 
CRP 1.41 1.48 (1.13–1.95) 0.005 1.29 (0.96–1.73) 0.09 1.05 (0.76–1.46) 0.77 
IL-6 1.00 1.23 (0.96–1.57) 0.10 1.11 (0.84–1.45) 0.47 1.03 (0.78–1.36) 0.84 
SAA 0.88 1.17 (0.92–1.48) 0.20 1.14 (0.88–1.49) 0.33 1.07 (0.81–1.41) 0.62 
A/L 1.11 0.43 (0.31–0.59) <0.001 0.54 (0.37–0.77) <0.001 0.66 (0.42–1.02) 0.06 
Independent variableSDModel 1*
Model 2
Model 3
OR (95% CI)POR (95% CI)POR (95% CI)P
Adiponectin 0.49 0.57 (0.44–0.73) <0.001 0.63 (0.48–0.83) 0.001 0.68 (0.51–0.90) 0.007 
Leptin 0.92 2.05 (1.44–2.90) <0.001 1.50 (1.02–2.21) 0.04 0.97 (0.58–1.62) 0.89 
CRP 1.41 1.48 (1.13–1.95) 0.005 1.29 (0.96–1.73) 0.09 1.05 (0.76–1.46) 0.77 
IL-6 1.00 1.23 (0.96–1.57) 0.10 1.11 (0.84–1.45) 0.47 1.03 (0.78–1.36) 0.84 
SAA 0.88 1.17 (0.92–1.48) 0.20 1.14 (0.88–1.49) 0.33 1.07 (0.81–1.41) 0.62 
A/L 1.11 0.43 (0.31–0.59) <0.001 0.54 (0.37–0.77) <0.001 0.66 (0.42–1.02) 0.06 

Data are OR (95% CI) per 1-SD change. n = 479 for models including adiponectin and n = 490 for models including leptin, CRP, IL-6, or SAA.

*

Adjusted for age and sex.

Adjusted for model 1 variables + triglycerides, HDL cholesterol, hypertension, and impaired glucose tolerance.

Adjusted for model 2 variables + waist circumference.

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