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Table 3—

Association between adiponectin and incident type 2 diabetes with addition of leptin, CRP, IL-6, and/or SAA: the Sandy Lake Health and Diabetes Project

AdiponectinLeptinCRPIL-6SAAC Statistic*
Base model 0.45 (0.25–0.81)     0.753 
+ Leptin 0.45 (0.25–0.81) 0.98 (0.55–1.74)    0.753 
+ CRP 0.45 (0.25–0.81)  0.99 (0.77–1.26)   0.753 
+ IL-6 0.45 (0.25–0.81)   0.98 (0.74–1.31)  0.753 
+ SAA 0.46 (0.26–0.81)    1.07 (0.79–1.47) 0.754 
+ Leptin + CRP 0.45 (0.25–0.81) 1.00 (0.97–1.03) 0.98 (0.77–1.26)   0.753 
+ Leptin + CRP + IL-6 0.45 (0.25–0.81) 1.00 (0.97–1.03) 0.99 (0.76–1.28) 0.99 (0.72–1.35)  0.753 
+ Leptin + CRP + IL-6 + SAA 0.45 (0.25–0.81) 1.00 (0.97–1.03) 0.95 (0.70–1.27) 0.97 (0.71–1.33) 1.13 (0.77–1.65) 0.755 
AdiponectinLeptinCRPIL-6SAAC Statistic*
Base model 0.45 (0.25–0.81)     0.753 
+ Leptin 0.45 (0.25–0.81) 0.98 (0.55–1.74)    0.753 
+ CRP 0.45 (0.25–0.81)  0.99 (0.77–1.26)   0.753 
+ IL-6 0.45 (0.25–0.81)   0.98 (0.74–1.31)  0.753 
+ SAA 0.46 (0.26–0.81)    1.07 (0.79–1.47) 0.754 
+ Leptin + CRP 0.45 (0.25–0.81) 1.00 (0.97–1.03) 0.98 (0.77–1.26)   0.753 
+ Leptin + CRP + IL-6 0.45 (0.25–0.81) 1.00 (0.97–1.03) 0.99 (0.76–1.28) 0.99 (0.72–1.35)  0.753 
+ Leptin + CRP + IL-6 + SAA 0.45 (0.25–0.81) 1.00 (0.97–1.03) 0.95 (0.70–1.27) 0.97 (0.71–1.33) 1.13 (0.77–1.65) 0.755 

Data are OR (95% CI) per 1-unit change (n = 479).

*

There were no significant differences between the C statistics of the baseline model and subsequent models adjusted with additional adipokine(s).

Outcome = incident diabetes; 1° exposure = adiponectin, with adjustment for age, sex, triglyceride, HDL cholesterol, hypertension, impaired glucose tolerance, and waist circumference.

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