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Table 2—

Percent change in risk factors for cardiovascular disease and diabetes over year 1 in those randomized to placebo

MenWomen
n 335 747 
Cardiometabolic risk factors   
    Fasting glucose 0.0 ± 11.9 −0.9 ± 11.9 
    TG −5.1 ± 46.8 −5.1 ± 40.8 
    HDL 0.0 ± 15.6 0.0 ± 17.6 
    BP −0.8/−1.3 ± 13/14 −0.9/−1.3 ± 13/16 
    Waist circumference −0.2 ± 4.8 −0.5 ± 6.1 
    Weight 0.0 ± 3.7 0.1 ± 4.5 
    BMI 0.0 ± 3.8 0.1 ± 5.2 
Physical activity 12.5 ± 125 6.6 ± 162 
Caloric intake −8.5 ± 42.7 −9.7 ± 36.9 
% on meds for TG or BP 0.5 8.3 
Diabetes risk factors   
    2-h glucose −6.9 ± 30.4 −4.8 ± 27.5 
    A1C 0.02 ± 0.06 0.00 ± 0.06 
    Insulin 5.0 ± 53.2 0.0 ± 57.1 
Index of insulin secretion   
    CIR −4.1 ± 57.1 −2.3 ± 59.4 
Index of insulin action   
    HOMA-IR 5.3 ± 61.0 0.2 ± 64.9 
MenWomen
n 335 747 
Cardiometabolic risk factors   
    Fasting glucose 0.0 ± 11.9 −0.9 ± 11.9 
    TG −5.1 ± 46.8 −5.1 ± 40.8 
    HDL 0.0 ± 15.6 0.0 ± 17.6 
    BP −0.8/−1.3 ± 13/14 −0.9/−1.3 ± 13/16 
    Waist circumference −0.2 ± 4.8 −0.5 ± 6.1 
    Weight 0.0 ± 3.7 0.1 ± 4.5 
    BMI 0.0 ± 3.8 0.1 ± 5.2 
Physical activity 12.5 ± 125 6.6 ± 162 
Caloric intake −8.5 ± 42.7 −9.7 ± 36.9 
% on meds for TG or BP 0.5 8.3 
Diabetes risk factors   
    2-h glucose −6.9 ± 30.4 −4.8 ± 27.5 
    A1C 0.02 ± 0.06 0.00 ± 0.06 
    Insulin 5.0 ± 53.2 0.0 ± 57.1 
Index of insulin secretion   
    CIR −4.1 ± 57.1 −2.3 ± 59.4 
Index of insulin action   
    HOMA-IR 5.3 ± 61.0 0.2 ± 64.9 

Data are medians ± interquartile range. BP, blood pressure; TG, triglyceride.

P < 0.05, men vs. women.

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