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Table 3—

Percent change in risk factors for cardiovascular disease and diabetes over year 1 in those randomized to ILS

<3% weight loss
3–7% weight loss
>7% weight loss
MenWomenMenWomenMenWomen
n 48 159 86 181 178 322 
Cardiometabolic risk factors       
    Fasting glucose −3.8 ± 15.1 −1.0 ± 10.7 −4.4 ± 10.5 −3.9 ± 9.8 −6.8 ± 11 −7.6 ± 9.1 
    TG −4.3 ± 42.9 1.5 ± 37.5 −13.3 ± 43 −11.1 ± 38 −28 ± 43 −19 ± 40* 
    HDL 0.0 ± 16.1 −2.0 ± 17.5 2.8 ± 21 2.0 ± 17 6.5 ± 18 4.6 ± 20 
    BP 1.2/0.0 ± 12/12 0.8/0.0 ± 12/14 −1.1/−3.6 ± 15/15 −2.1/−4.1 ± 14/15 −6.4/−8.9 ± 13/14 −4.9/−7.6 ± 12/14 
    Waist circumference −2.1 ± 5.4 −1.3 ± 5.2 −4.9 ± 4.0 −4.7 ± 5.2 −9.3 ± 6.5 8.7 ± 6.9 
    BMI −0.8 ± 2.5 −0.6 ± 2.7 −5.4 ± 1.8 5.0 ± 2.2 −10.2 ± 5.5 −11.1 ± 5.7 
Physical activity 51 ± 167 30 ± 187 43 ± 162 42 ± 230 67 ± 221 92 ± 281 
Caloric intake −8.4 ± 40 −19.2 ± 38 −17.5 ± 47 −22.4 ± 36 −18.7 ± 36 −21.1 ± 39 
% on meds for TG or BP 0.0 0.0 0.0 0.0 0.0 0.0 
Diabetes risk factors       
    2-h glucose −6.9 ± 30 −5.2 ± 27 −22 ± 29 −13 ± 27* −26 ± 30 −19 ± 26* 
    A1C −0.02 ± 0.05 0.00 ± 0.07 −0.02 ± 0.05 −0.02 ± 0.05 −0.03 ± 0.06 −0.02 ± 0.05 
    Insulin −2.9 ± 49 −5.9 ± 52 −19 ± 50 −11 ± 49 −39 ± 41 −33 ± 40 
Index of insulin secretion       
    CIR −0.9 ± 65 2.7 ± 61 0.9 ± 69 −3.1 ± 65 3.6 ± 68 4.3 ± 66 
Index of insulin action       
    HOMA-IR −4.4 ± 70 −6.0 ± 61 −25 ± 49 −15 ± 51 −40–5 ± 44 −39 ± 37 
<3% weight loss
3–7% weight loss
>7% weight loss
MenWomenMenWomenMenWomen
n 48 159 86 181 178 322 
Cardiometabolic risk factors       
    Fasting glucose −3.8 ± 15.1 −1.0 ± 10.7 −4.4 ± 10.5 −3.9 ± 9.8 −6.8 ± 11 −7.6 ± 9.1 
    TG −4.3 ± 42.9 1.5 ± 37.5 −13.3 ± 43 −11.1 ± 38 −28 ± 43 −19 ± 40* 
    HDL 0.0 ± 16.1 −2.0 ± 17.5 2.8 ± 21 2.0 ± 17 6.5 ± 18 4.6 ± 20 
    BP 1.2/0.0 ± 12/12 0.8/0.0 ± 12/14 −1.1/−3.6 ± 15/15 −2.1/−4.1 ± 14/15 −6.4/−8.9 ± 13/14 −4.9/−7.6 ± 12/14 
    Waist circumference −2.1 ± 5.4 −1.3 ± 5.2 −4.9 ± 4.0 −4.7 ± 5.2 −9.3 ± 6.5 8.7 ± 6.9 
    BMI −0.8 ± 2.5 −0.6 ± 2.7 −5.4 ± 1.8 5.0 ± 2.2 −10.2 ± 5.5 −11.1 ± 5.7 
Physical activity 51 ± 167 30 ± 187 43 ± 162 42 ± 230 67 ± 221 92 ± 281 
Caloric intake −8.4 ± 40 −19.2 ± 38 −17.5 ± 47 −22.4 ± 36 −18.7 ± 36 −21.1 ± 39 
% on meds for TG or BP 0.0 0.0 0.0 0.0 0.0 0.0 
Diabetes risk factors       
    2-h glucose −6.9 ± 30 −5.2 ± 27 −22 ± 29 −13 ± 27* −26 ± 30 −19 ± 26* 
    A1C −0.02 ± 0.05 0.00 ± 0.07 −0.02 ± 0.05 −0.02 ± 0.05 −0.03 ± 0.06 −0.02 ± 0.05 
    Insulin −2.9 ± 49 −5.9 ± 52 −19 ± 50 −11 ± 49 −39 ± 41 −33 ± 40 
Index of insulin secretion       
    CIR −0.9 ± 65 2.7 ± 61 0.9 ± 69 −3.1 ± 65 3.6 ± 68 4.3 ± 66 
Index of insulin action       
    HOMA-IR −4.4 ± 70 −6.0 ± 61 −25 ± 49 −15 ± 51 −40–5 ± 44 −39 ± 37 

Data are medians ± interquartile range. BP, blood pressure; TG, triglyceride.

*

P < 0.01, men vs. women;

P < 0.05, men vs. women.

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