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Table 1—

Distribution of risk factors and inflammatory/hemostatic markers in 3,562 nondiabetic subjects aged 60–79 years at reexamination according to diabetes status at follow-up

Developed diabetes
P for difference
NoYes
n 3,400 162  
Age (years) 68.7 (5.6) 68.4 (5.4) 0.56 
BMI (kg/m226.6 (3.5) 29.7 (4.1) <0.0001 
Waist circumference (cm) 96.2 (9.9) 104.1 (10.4) <0.0001 
Current smokers (%) 13.3 9.3 0.14 
Inactive (%) 32.4 45.2 0.0008 
Manual (%) 53.1 64.6 0.004 
Heavy drinkers (>5 drinks/day) (%) 3.7 2.5 0.42 
Parental history of diabetes (%) 5.4 9.9 <0.0001 
CHD (%) 17.6 32.1 <0.0001 
Use of statins (%) 6.5 13.6 0.0005 
Stroke (%) 5.0 6.2 0.57 
SBP (mmHg) 148.2 ± 23.9 153.0 ± 22.7 0.01 
Triglyceride (mmol/l) 1.57 (1.12–2.13) 2.10 (1.54–2.81) <0.0001 
HDL (mmol/l) 1.34 ± 0.34 1.17 ± 0.29 <0.0001 
Glucose (mmol/l) 5.52 (5.21–5.89) 5.99 (5.59–6.52) <0.0001 
Log HOMA-IR 0.65 ± 0.58 1.27 ± 0.57 <0.0001 
CRP (mg/l) 1.67 (0.80–3.30) 2.59 (1.27–4.42) <0.0001 
IL-6 (pg/ml) 2.41 (1.55–3.42) 2.92 (1.93–4.23) <0.0001 
Adiponectin (μg/ml) 7.11 (4.52–11.46) 4.96 (3.11–7.39) <0.0001 
GGT (IU/l) 27.4 (18–37) 37.0 (24–52.5) <0.0001 
ALT (IU/l) 15.2 (12–20) 19.5 (13.5–28.0) <0.0001 
vWF (IU/dl) 137.8 ± 44.4 146.4 ± 48.1 0.02 
t-PA (ng/ml) 10.74 ± 4.21 13.37 ± 4.79 <0.0001 
Developed diabetes
P for difference
NoYes
n 3,400 162  
Age (years) 68.7 (5.6) 68.4 (5.4) 0.56 
BMI (kg/m226.6 (3.5) 29.7 (4.1) <0.0001 
Waist circumference (cm) 96.2 (9.9) 104.1 (10.4) <0.0001 
Current smokers (%) 13.3 9.3 0.14 
Inactive (%) 32.4 45.2 0.0008 
Manual (%) 53.1 64.6 0.004 
Heavy drinkers (>5 drinks/day) (%) 3.7 2.5 0.42 
Parental history of diabetes (%) 5.4 9.9 <0.0001 
CHD (%) 17.6 32.1 <0.0001 
Use of statins (%) 6.5 13.6 0.0005 
Stroke (%) 5.0 6.2 0.57 
SBP (mmHg) 148.2 ± 23.9 153.0 ± 22.7 0.01 
Triglyceride (mmol/l) 1.57 (1.12–2.13) 2.10 (1.54–2.81) <0.0001 
HDL (mmol/l) 1.34 ± 0.34 1.17 ± 0.29 <0.0001 
Glucose (mmol/l) 5.52 (5.21–5.89) 5.99 (5.59–6.52) <0.0001 
Log HOMA-IR 0.65 ± 0.58 1.27 ± 0.57 <0.0001 
CRP (mg/l) 1.67 (0.80–3.30) 2.59 (1.27–4.42) <0.0001 
IL-6 (pg/ml) 2.41 (1.55–3.42) 2.92 (1.93–4.23) <0.0001 
Adiponectin (μg/ml) 7.11 (4.52–11.46) 4.96 (3.11–7.39) <0.0001 
GGT (IU/l) 27.4 (18–37) 37.0 (24–52.5) <0.0001 
ALT (IU/l) 15.2 (12–20) 19.5 (13.5–28.0) <0.0001 
vWF (IU/dl) 137.8 ± 44.4 146.4 ± 48.1 0.02 
t-PA (ng/ml) 10.74 ± 4.21 13.37 ± 4.79 <0.0001 

Data are means ± SD or geometric means (interquartile range) for skewed variables. SBP, systolic blood pressure.

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