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Table 3—

Incidence rates and adjusted relative risk of type 2 diabetes according to thirds of inflammatory and endothelial markers

Endothelial markersThirds
Ptrend
LowestMiddleTop
t-PA (ng/ml) <8.7 8.7 12.1  
    Rate/1,000 person-years 2.6 6.3 11.6  
    Model 1 1.00 2.36 (1.40–3.99) 4.54 (2.76–7.47) <0.0001 
    Model 2 1.00 1.89 (1.12–3.20) 2.98 (1.79–5.00) <0.0001 
    Model 3 1.00 1.81 (1.07–3.07) 2.65 (1.58–4.45) <0.0001 
    Model 3 + GGT 1.00 1.65 (0.97–2.81) 2.19 (1.29–3.70) 0.0003 
    Model 3 + HOMA-IR 1.00 1.35 (0.78–2.32) 1.92 (1.12–3.27) 0.001 
    Model 3 + GGT + HOMA-IR 1.00 1.25 (0.72–2.16) 1.66 (0.96–2.85) 0.02 
vWF (IU/dl) <115 115 155  
    Rate/1,000 person-years 5.8 6.1 8.4  
    Model 1 1.00 1.04 (0.70–1.56) 1.39 (0.94–2.03) 0.007 
    Model 2 1.00 0.94 (0.62–1.41) 1.24 (0.83–1.85) 0.05 
    Model 3 1.00 0.91 (0.61–1.38) 1.18 (0.79–1.78) 0.11 
    Model 3 + GGT 1.00 0.87 (0.57–1.31) 1.06 (0.71–1.60) 0.31 
    Model 3 + HOMA-IR 1.00 0.87 (0.57–1.32) 1.10 (0.73–1.66) 0.27 
    Model 3 + GGT + HOMA-IR 1.00 0.84 (0.55–1.28) 1.01 (0.67–1.53) 0.49 
Endothelial markersThirds
Ptrend
LowestMiddleTop
t-PA (ng/ml) <8.7 8.7 12.1  
    Rate/1,000 person-years 2.6 6.3 11.6  
    Model 1 1.00 2.36 (1.40–3.99) 4.54 (2.76–7.47) <0.0001 
    Model 2 1.00 1.89 (1.12–3.20) 2.98 (1.79–5.00) <0.0001 
    Model 3 1.00 1.81 (1.07–3.07) 2.65 (1.58–4.45) <0.0001 
    Model 3 + GGT 1.00 1.65 (0.97–2.81) 2.19 (1.29–3.70) 0.0003 
    Model 3 + HOMA-IR 1.00 1.35 (0.78–2.32) 1.92 (1.12–3.27) 0.001 
    Model 3 + GGT + HOMA-IR 1.00 1.25 (0.72–2.16) 1.66 (0.96–2.85) 0.02 
vWF (IU/dl) <115 115 155  
    Rate/1,000 person-years 5.8 6.1 8.4  
    Model 1 1.00 1.04 (0.70–1.56) 1.39 (0.94–2.03) 0.007 
    Model 2 1.00 0.94 (0.62–1.41) 1.24 (0.83–1.85) 0.05 
    Model 3 1.00 0.91 (0.61–1.38) 1.18 (0.79–1.78) 0.11 
    Model 3 + GGT 1.00 0.87 (0.57–1.31) 1.06 (0.71–1.60) 0.31 
    Model 3 + HOMA-IR 1.00 0.87 (0.57–1.32) 1.10 (0.73–1.66) 0.27 
    Model 3 + GGT + HOMA-IR 1.00 0.84 (0.55–1.28) 1.01 (0.67–1.53) 0.49 

Data are relative risk (95% CI). Model 1, adjusted for age, social class, smoking, alcohol intake, physical activity, parental history of diabetes, preexisting CHD, stroke, and use of statins; model 2, model 1 plus waist circumference; and model 3, model 2 plus adiponectin and IL-6.

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