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Table 2—

Characteristics at baseline and study end: metformin and OCP group

CharacteristicMetformin
OCP
P value for change over study: metformin vs. OCP
BeforeAfterBeforeAfter
n 19  19   
BMI (kg/m238.4 ± 1.6 37.7 ± 1.6 35.3 ± 1.8 35.3 ± 1.8 0.26 
Weight (kg) 105.2 ± 4.7 103.4 ± 4.6 94.1 ± 5.0 94.2 ± 5.0 0.24 
Waist circumference (cm) 112.6 ± 3.5 113.7 ± 4.0 105.1 ± 3.8 107.2 ± 3.5 0.52 
Waist-to-hip ratio 0.9 ± 0 0.9 ± 0 0.9 ± 0 0.9 ± 0 0.65 
hsCRP (mg/l) 4.2 ± 0.68 3.8 ± 0.73 4.6 ± 0.93 7.4 ± 2.0 0.03 
Testosterone (nmol/l) 2.4 ± 0.1 2.2 ± 0.3 2.1 ± 0.2 1.7 ± 0.1 0.87 
SHBG (nmol/l) 32.4 ± 4.4 43.2 ± 9.6 31.7 ± 2.8 133.7 ± 17* <0.01 
FAI 9.9 ± 1.5 10.7 ± 2.7 8.5 ± 1.7 1.8 ± 0.3* <0.01 
Cholesterol (mmol/l) 5.3 ± 0.3 5.1 ± 0.3 5.1 ± 0.2 4.9 ± 0.2 0.81 
HDL cholesterol (mmol/l) 1.2 ± 0.1 1.1 ± 0.1* 1.4 ± 0.1 1.4 ± 0.1 0.01 
LDL cholesterol (mmol/l) 3.4 ± 0.3 3.2 ± 0.3 3.2 ± 0.2 2.7 ± 0.2* 0.15 
Triglycerides (mmol/l) 1.6 ± 0.1 1.6 ± 0.2 1.2 ± 0.1 1.7 ± 0.2* <0.01 
Fasting glucose (mmol/l) 4.7 ± 0.2 4.6 ± 0.2 4.4 ± 0.1 4.3 ± 0.1 0.74 
Fasting insulin (mU/l) 21.5 ± 4.2 17.8 ± 5 21 ± 4.4 20.8 ± 2.9 0.1 
AUC insulin (mU · l−1 · 120 min−112,333.9 ± 2,046.4 8,054.7 ± 1,090.6* 9,339.8 ± 1,531.5 12,413.5 ± 1,616.7* <0.01 
HOMA 4.7 ± 1.1 4.2 ± 1.7 4.2 ± 0.9 4 ± 0.6 0.1 
RBP4 (μg/l) 35.9 ± 7.4 43.7 ± 6.3 35.7 ± 5.3 42.6 ± 5.5 0.92 
CharacteristicMetformin
OCP
P value for change over study: metformin vs. OCP
BeforeAfterBeforeAfter
n 19  19   
BMI (kg/m238.4 ± 1.6 37.7 ± 1.6 35.3 ± 1.8 35.3 ± 1.8 0.26 
Weight (kg) 105.2 ± 4.7 103.4 ± 4.6 94.1 ± 5.0 94.2 ± 5.0 0.24 
Waist circumference (cm) 112.6 ± 3.5 113.7 ± 4.0 105.1 ± 3.8 107.2 ± 3.5 0.52 
Waist-to-hip ratio 0.9 ± 0 0.9 ± 0 0.9 ± 0 0.9 ± 0 0.65 
hsCRP (mg/l) 4.2 ± 0.68 3.8 ± 0.73 4.6 ± 0.93 7.4 ± 2.0 0.03 
Testosterone (nmol/l) 2.4 ± 0.1 2.2 ± 0.3 2.1 ± 0.2 1.7 ± 0.1 0.87 
SHBG (nmol/l) 32.4 ± 4.4 43.2 ± 9.6 31.7 ± 2.8 133.7 ± 17* <0.01 
FAI 9.9 ± 1.5 10.7 ± 2.7 8.5 ± 1.7 1.8 ± 0.3* <0.01 
Cholesterol (mmol/l) 5.3 ± 0.3 5.1 ± 0.3 5.1 ± 0.2 4.9 ± 0.2 0.81 
HDL cholesterol (mmol/l) 1.2 ± 0.1 1.1 ± 0.1* 1.4 ± 0.1 1.4 ± 0.1 0.01 
LDL cholesterol (mmol/l) 3.4 ± 0.3 3.2 ± 0.3 3.2 ± 0.2 2.7 ± 0.2* 0.15 
Triglycerides (mmol/l) 1.6 ± 0.1 1.6 ± 0.2 1.2 ± 0.1 1.7 ± 0.2* <0.01 
Fasting glucose (mmol/l) 4.7 ± 0.2 4.6 ± 0.2 4.4 ± 0.1 4.3 ± 0.1 0.74 
Fasting insulin (mU/l) 21.5 ± 4.2 17.8 ± 5 21 ± 4.4 20.8 ± 2.9 0.1 
AUC insulin (mU · l−1 · 120 min−112,333.9 ± 2,046.4 8,054.7 ± 1,090.6* 9,339.8 ± 1,531.5 12,413.5 ± 1,616.7* <0.01 
HOMA 4.7 ± 1.1 4.2 ± 1.7 4.2 ± 0.9 4 ± 0.6 0.1 
RBP4 (μg/l) 35.9 ± 7.4 43.7 ± 6.3 35.7 ± 5.3 42.6 ± 5.5 0.92 

Data are means ± SEM. Baseline data were assessed using one-way ANOVA with intervention as the between-subject factors and intervention data were assessed using repeated-measures ANOVA with time as the within-subject factor and intervention as the between-subject factor.

*

P < 0.05 for within-group change over study intervention.

P < 0.05 for difference between OCP and metformin group at study beginning or end.

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